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Organ Preservation pp 27–32Cite as

Biological significance and therapeutic potential of prostacyclin

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Abstract

Prostacyclin and thromboxane A2 (TXA2) are both derived from arachidonic acid, a fatty acid present in the phospholipids of cell membranes. TXA2 is an unstable (t1/2 30s at 37 °C), powerful vasoconstrictor agent generated by platelets1. Prostacyclin is also unstable (t1/2 3 min at 37 °C) but induces vasodilatation and inhibits platelet aggregation. Prostacyclin and thromboxane A2 represent, therefore, the opposite poles of a homeostatic mechanism for regulation of platelet aggregability in vivo. Manipulation of this control mechanism will affect thrombus and haemostatic plug formation.

* This chapter was previously published in Advanced Medicine 17, and is reproduced by permission of the authors and the publishers, Pitman Medical Limited, Tunbridge Wells, U.K.

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Authors
  1. S. Moncada
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  2. J. R. Vane
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Editor information

Editors and Affiliations

  1. MRC Medical Cryobiology Group, University Department of Surgery, Douglas House,Trumpington Road, CB2 2AH, Cambridge, UK

    D. E. Pegg

  2. Department of Nephrology, University Hospital, DK-5000, Odense C, Denmark

    I. A. Jacobsen

  3. Department of Surgery, University of California Medical Center, 225 Dickinson Street, 92103, San Diego, California, USA

    N. A. Halasz

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© 1982 MTP Press Limited

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Moncada, S., Vane, J.R. (1982). Biological significance and therapeutic potential of prostacyclin. In: Pegg, D.E., Jacobsen, I.A., Halasz, N.A. (eds) Organ Preservation. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6267-8_3

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  • DOI: https://doi.org/10.1007/978-94-011-6267-8_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6269-2

  • Online ISBN: 978-94-011-6267-8

  • eBook Packages: Springer Book Archive

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