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Membrane functions

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Book cover Organ Preservation

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Abstract

The use of hypothermic conditions for either storage or continuous perfusion of isolated organs has for some years been regarded as a prerequisite for their continuing viability. The rationale for such approaches has remained, however, largely empirical, and is based on the principle that if metabolism is responsible for tissue deterioration, and metabolic processes are temperature-dependent, then a reduction in temperature should lead to extended survival of isolated organs. The very fact that the application of hypothermic techniques has met with some success has proved to be a mixed blessing. On the one hand it has generated much research effort devoted to optimizing both the composition of perfusing media and the operating temperature. On the other hand it has tended to obscure a detailed appraisal of the effects of temperatureper se on cell function.

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Authors
  1. M. J. Pringle
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Editors and Affiliations

  1. MRC Medical Cryobiology Group, University Department of Surgery, Douglas House,Trumpington Road, CB2 2AH, Cambridge, UK

    D. E. Pegg

  2. Department of Nephrology, University Hospital, DK-5000, Odense C, Denmark

    I. A. Jacobsen

  3. Department of Surgery, University of California Medical Center, 225 Dickinson Street, 92103, San Diego, California, USA

    N. A. Halasz

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© 1982 MTP Press Limited

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Pringle, M.J. (1982). Membrane functions. In: Pegg, D.E., Jacobsen, I.A., Halasz, N.A. (eds) Organ Preservation. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6267-8_2

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  • DOI: https://doi.org/10.1007/978-94-011-6267-8_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6269-2

  • Online ISBN: 978-94-011-6267-8

  • eBook Packages: Springer Book Archive

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