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Atherosclerosis in males and females

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Hormones and Atherosclerosis

Abstract

Ischaemic heart disease is commoner in young men than in young women1. In England and Wales in 1973 there were 1942 deaths from coronary heart disease in women aged 30–34 compared to 10692 in men during the same period2. However, after the age of about 50 years the incidence of ischaemic heart disease in men and women tends to equalize and after about 70 the incidences are much the same.

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References

  1. Oliver, M. F. (ed.) (1978). Coronary Heart Disease in Young Women. (Edinburgh: Churchill Livingstone)

    Google Scholar 

  2. Editorial (1977). Coronary heart disease in young women. Lancet, 2, 282

    Google Scholar 

  3. Kagan, A., Dawber, T. R., Kannel, W. B. and Revotskie, N. (1962). The Framingham study: a prospective study of coronary heart diseases. Fed. Proc., 21, suppl. 2, 52

    PubMed  Google Scholar 

  4. Kannel, W. B., Hjortland, M. C., McNamara, P. M. and Gordon, T. (1976). Menopause and risk of cardiovascular disease. The Framingham study. Ann. Intern. Med., 85, 447

    PubMed  CAS  Google Scholar 

  5. Kannel, W. B., Dawber, T. R., Cohen, M. E. and McNamara, P. M. (1965). Vascular disease of the brain — epidemiologic aspects: The Framingham study. Am. J. Publ. Health, 55, 1355

    Article  CAS  Google Scholar 

  6. Bengtsson, C. (1973). Ischaemic heart disease in women. Acta Med. Scand., suppl. 549, 1

    CAS  Google Scholar 

  7. Haberman, S., Capildeo, R. and Rose, F. C. (1978). The changing mortality of cerebrovascular disease. Q. J. Med., 47, 71

    PubMed  CAS  Google Scholar 

  8. Phillips, G. B. (1976). Evidence for hyperoestrogenaemia as a risk factor for myocardial infarction in men. Lancet, 2, 14

    Article  PubMed  CAS  Google Scholar 

  9. Entrican, J. G., Beach, C., Carroll, D. et al. (1978). Raised plasma oestradiol and oestrone levels in young survivors of myocardial infarction. Lancet, 2, 487

    Article  PubMed  CAS  Google Scholar 

  10. Taggart, H., Sheridan, B. and Stout, R. W. (1980). Sex hormone levels in younger male stroke survivors. Atherosclerosis, 35, 123

    Article  PubMed  CAS  Google Scholar 

  11. Goodale, F., Thomas, W. A. and O’Neal, R. M. (1960). Myocardial infarction in women. Arch. Pathol., 69, 599

    PubMed  CAS  Google Scholar 

  12. Mitchell, J. R. A. and Schwartz, C. J. (1965). Arterial Disease. (Oxford: Blackwell)

    Google Scholar 

  13. Kuller, L. and Lilienfeld, A. (1966). Epidemiological study of sudden and unexpected deaths due to arteriosclerotic heart disease. Circulation, 34, 1056

    PubMed  CAS  Google Scholar 

  14. Sternley, N. H. (1968). Atherosclerosis in a defined population. Acta Pathol. Microbiol. Scand., suppl. 194, 1

    Google Scholar 

  15. Tejada, C., Strong, J. P., Montenegro, M. R., Restrepo, C. and Selberg, L. A. (1968). Distribution of coronary and aortic atherosclerosis by geographic location, race and sex. Lab. Invest., 18, 509

    PubMed  CAS  Google Scholar 

  16. James, J. N., Post, H. W. and Smith, F. J. (1955). Myocardial infarction in women. Ann. Intern. Med., 43, 153

    PubMed  CAS  Google Scholar 

  17. Oliver, M. F. (1974). Ischaemic heart disease in young women. Br. Med. J., 4, 253

    Article  PubMed  CAS  Google Scholar 

  18. Mann, J. I., Doll, R., Thorogood, M., Vessey, M. P. and Waters, W. E. (1976). Risk factors for myocardial infarction in young women. Br. I. Prev. Soc. Med., 30, 94

    CAS  Google Scholar 

  19. Morris, D. C., Hurst, J. W. and Logue, R. B. (1976). Myocardial infarction in young women. Am. J. Cardiol., 38, 299

    Article  PubMed  CAS  Google Scholar 

  20. Adlersberg, D., Schaefer, L. E., Steinberg, A. G. and Wang, C. I. (1956). Age, sex, serum lipids and coronary atherosclerosis. I. Am. Med. Assoc., 162, 619

    Article  CAS  Google Scholar 

  21. Wood, P. D. S., Stern, M. P. and Silvers, A. (1972). Prevalence of plasma lipoprotein abnormalities in a free-living population of the Central Valley, California. Circulation, 45, 114

    PubMed  CAS  Google Scholar 

  22. Lewis, B., Chait, A., Wooton, I. D. P. et al. (1974). Frequency of risk factors for ischaemic heart disease in a healthy British population. Lancet, 1, 141

    Article  PubMed  CAS  Google Scholar 

  23. Garcia, M. J., McNamara, P. M., Gordon, T. and Kannel, W. B. (1974). Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study. Diabetes, 23, 105

    PubMed  CAS  Google Scholar 

  24. Hjortland, M. C., McNamara, P. M. and Kannel, W. B. (1976). Some atherogenic concomitants of menopause: the Framingham study. Am. J. Epidemiol., 103, 304

    PubMed  CAS  Google Scholar 

  25. Gordon, T., Kannel, W. B., Hjortland, M. C. and McNamara, P. M. (1978). Menopause and coronary heart disease. The Framingham study. Ann. Intern. Med., 89, 157

    PubMed  CAS  Google Scholar 

  26. Bengtsson, A. and Lindquist, O. (1978). Coronary heart disease during the menopause. In Oliver, M. F. (ed.) Coronary Heart Disease in Young Women, pp. 234–42. (Edinburgh: Churchill Livingstone)

    Google Scholar 

  27. Editorial (1977). Coronary heart disease and the menopause. Br. Med. J., 1, 862

    Article  Google Scholar 

  28. Weiss, N. S. (1972). Relationship of menopause to serum cholesterol and arterial blood pressure — the United States health examination survey of adults. Am. J. Epidemiol., 96, 237

    Google Scholar 

  29. Hallberg, L. and Svanborg, A. (1967). Cholesterol, phospholipids and triglycerides in plasma in 50 year-old women. Acta Med. Scand., 181, 185

    Article  PubMed  CAS  Google Scholar 

  30. Taylor, R. D., Corcoron, A. C. and Page, I. H. (1974). Menopausal hypertension: a critical study. Am. J. Med. Sci., 213, 475

    Article  Google Scholar 

  31. Doll, R. (1978). Discussion. In Oliver, M. F. (ed.) Coronary Heart Disease in Young Wome., pp. 22–3. (Edinburgh: Churchill Livingstone)

    Google Scholar 

  32. Wilhelmsen, L. (1978). Epidemiology of coronary heart disease in young women. In Oliver, M. F. (ed.) Coronary Heart Disease in Young Wome., pp. 3–9. (Edinburgh: Churchill Livingstone)

    Google Scholar 

  33. Baird, D. T. (1978). Patterns of sex hormone production in women. In Oliver, M. F. (ed.) Coronary Heart Disease in Young Wome., pp. 95–100. (Edinburgh: Churchill Livingstone)

    Google Scholar 

  34. Vermeulen, A. (1978). Patterns of sex hormone production in men. In Oliver, M. F. (ed.) Coronary Heart Disease in Young Women, pp. 101–5. (Edinburgh: Churchill Livingstone)

    Google Scholar 

  35. Kley, H. K., Edelmann, P. and Kruskemper, H. L. (1980). Relationship of plasma sex hormones to different parameters of obesity in male subjects. Metabolism, 29, 1041

    Article  PubMed  CAS  Google Scholar 

  36. Wuest, J. E., Dry, T. J. and Edwards, J. E. (1953). The degree of coronary atherosclerosis in bilaterally oophorectomised women. Circulation, 7, 801

    PubMed  Google Scholar 

  37. Parrish, H. M., Carr, C. A., Hall, D. G. and King, T. M. (1967). Time interval from castration in premenopausal women to development of excessive coronary atherosclerosis. Am. J. Obstet. Gynecol., 99, 155

    PubMed  CAS  Google Scholar 

  38. Robinson, R. W., Higano, N. and Cohen, W. D. (1959). Increased incidence of coronary heart disease in women castrated prior to the menopause. Arch. Intern. Med., 104, 908

    Article  PubMed  CAS  Google Scholar 

  39. Higano, N., Robinson, R. W. and Cohen, W. D. (1963). Increased incidence of cardiovascular disease in castrated women: two-year follow-up study. N. Engl. I. Med., 268, 1123

    Article  CAS  Google Scholar 

  40. Oliver, M. F. and Boyd, G. S. (1959). Effect of bilateral ovariectomy on coronary-artery disease and serum-lipid levels. Lancet, 2, 690

    Article  PubMed  CAS  Google Scholar 

  41. Sznajderman, M. and Oliver, M. F. (1963). Spontaneous premature menopause, ischaemic heart disease and serum lipids. Lancet, 1, 962.

    Article  Google Scholar 

  42. Novak, E. R. and Williams, T. J. (1960). Autopsy comparison of cardiovascular changes in castrated and normal women. Am. J. Obstet. Gynecol., 80, 863

    PubMed  CAS  Google Scholar 

  43. Manchester, J. H., Herman, M. V. and Gorlin, R. (1971). Premenopausal castration and documented coronary atherosclerosis. Am. J. Cardiol., 28, 33

    Article  PubMed  CAS  Google Scholar 

  44. Blanc, J. J., Boschat, J., Morin, I.-F., Clavier, J. and Penther, T. (1977). Menopause and myocardial infarction. Am. J. Obstet. Gynecol., 127, 353

    PubMed  CAS  Google Scholar 

  45. Roberts, W. C. and Giraldo, A. A. (1979). Bilateral oophorectomy in menstruating women and accelerated coronary atherosclerosis: an unproved connection. Am. J. Med., 67, 363

    Article  PubMed  CAS  Google Scholar 

  46. Heller, R. F. and Jacobs, H. S. (1978). Coronary heart disease in relation to age, sex and the menopause. Br. Med. J., 1, 472

    Article  PubMed  CAS  Google Scholar 

  47. Vermeulen, A., Rubens, R. and Verdonck, L. (1972). Testosterone secretion and metabolism in male senescence. I. Clin. Endocrinol. Metab., 34, 730

    Article  CAS  Google Scholar 

  48. Rubens, R., Dhont, M. and Vermeulen, A. (1974). Further studies on Leydig cell function in old age. J. Clin. Endocrinol. Metab., 39, 40

    Article  PubMed  CAS  Google Scholar 

  49. Pirke, K. M. and Doerr, P. (1973). Age-related changes and interrelationships between plasma testosterone, oestradiol and testosterone-oestradiol binding globulin in normal adult males. Acta Endocrinol., 74, 792

    PubMed  CAS  Google Scholar 

  50. Stearns, E. L., MacDonnell, J. A., Kaufman, B. J. et al. (1974). Declining testicular function with age. Hormonal and clinical correlates. Am. J. Med., 57, 761

    Article  PubMed  CAS  Google Scholar 

  51. Phillips, G. B. (1977). Relationship between serum sex hormones and glucose, insulin, and lipid abnormalities in men with myocardial infarction. Proc. Natl. Acad. Sci. USA, 74, 1729

    Article  PubMed  CAS  Google Scholar 

  52. Levin, L. C. and Koreman, S. G. (1978). Elevated estradiol levels in acute MI and coronary artery disease. Clin. Res., 26, 308A

    Google Scholar 

  53. Heller, R. F., Jacobs, H. S., Vermeulen, A. and Deslypere, J. P. (1981). Androgens, oestrogens and coronary heart disease. Br. Med. J., 282, 438

    Article  CAS  Google Scholar 

  54. Carr, D. (1978). Oestrogens, myocardial infarction and smoking. Lancet, 2, 1048

    Article  PubMed  CAS  Google Scholar 

  55. Taggart, H. and Stout, R. W. (1979). Reduced high density lipoprotein in stroke: relationship with elevated triglyceride and hypertension Eur. J. Clin. Invest., 9, 219

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. The Queen’s University of Belfast, UK

    Robert W. Stout MD, FRCP (Professor of Geriatric Medicine)

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  1. Robert W. Stout MD, FRCP
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© 1982 R. W. Stout

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Stout, R.W. (1982). Atherosclerosis in males and females. In: Hormones and Atherosclerosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6264-7_9

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  • DOI: https://doi.org/10.1007/978-94-011-6264-7_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6266-1

  • Online ISBN: 978-94-011-6264-7

  • eBook Packages: Springer Book Archive

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