Vascular disease and experimental diabetes



Although the production of arterial lesions in animals fed high fat and cholesterol diets had been described at the beginning of the twentieth century, and experimental models of diabetes were available at the time Banting and Best isolated insulin in 1920, it was not until the 1940s that attempts were made to study the interaction of diabetes and atherosclerosis in the experimental animal. The first report of vascular lesions in an animal with experimental diabetes was that of Dragstedt and colleagues in 19401. They noted that dogs which were pancreatectomized and kept alive with insulin injections had an abnormally high frequency of lipid-containing lesions in their aortas compared to control dogs.


Smooth Muscle Cell Vascular Lesion Experimental Diabetes Aortic Smooth Muscle Cell Arterial Smooth Muscle Cell 
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Copyright information

© R. W. Stout 1982

Authors and Affiliations

  1. 1.The Queen’s University of BelfastUK

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