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Risk factors for atherosclerosis in diabetes

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Abstract

Atherosclerosis occurs more often and at an earlier age in diabetics than in non-diabetics. A possible explanation for this is that risk factors for atherosclerosis in the general population are more common in diabetics. This chapter discusses the prevalence of cardiovascular risk factors in diabetes and their relationship to atherosclerosis in diabetics. Some characteristics of diabetes itself will also be discussed. Abnormalities of lipid metabolism in diabetes are the subject of another chapter.

Keywords

Impaired Glucose Tolerance Framingham Study Coronary Heart Disease Mortality High Carbohydrate Diet Diabetic Autonomic Neuropathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Garcia, M. J., McNamara, P. M., Gordon, T. and Kannel, W. B. (1974). Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study. Diabetes, 23, 105PubMedGoogle Scholar
  2. 2.
    Kannel, W. B. and McGee, D. L. (1979). Diabetes and cardiovascular disease. The Framingham study. J. Am. Med. Assoc., 241, 2035CrossRefGoogle Scholar
  3. 3.
    Kannel, W. B. and Dawber, T. R. (1974). Hypertension as an ingredient of a cardiovascular risk profile. Br. J. Hosp. Med., 11, 508Google Scholar
  4. 4.
    Veterans Administration Co-operative Study Group on Anti-hypertensive Agents (1967). Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressure averaging 115 through 129 mm Hg. J. Am. Med. Assoc., 202, 1028CrossRefGoogle Scholar
  5. 5.
    Veterans Administration Co-operative Study Group on Anti-hypertensive Agents (1970). Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg. J. Am. Med. Assoc., 213, 1143CrossRefGoogle Scholar
  6. 6.
    Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B. and Dawber, T. R. (1977). Diabetes, blood lipids, and the role of obesity in coronary heart disease risk for women. The Framingham study. Ann. Intern. Med., 87, 393PubMedGoogle Scholar
  7. 7.
    Medalie, J. H., Papier, C. M., Goldbourt, U. and Herman, J. B. (1975). Major factors in the development of diabetes mellitus in 10000 men. Arch. Intern. Med., 135, 811PubMedCrossRefGoogle Scholar
  8. 8.
    Ostrander, L. D., Francis, T., Hayner, N. S., Kjelsberg, M. O. and Epstein, F. H. (1965). The relationship of cardiovascular disease to hyperglycemia. Arch. Intern. Med., 62, 1188Google Scholar
  9. 9.
    Pell, S. and D’Alonzo, C. A. (1967). Some aspects of hypertension in diabetes mellitus. J. Am. Med. Assoc., 202, 10CrossRefGoogle Scholar
  10. 10.
    Keen, H., Track, N. S. and Sowry, G. S. C. (1975). Arterial pressure in clinically apparent diabetics. Diabete Metab., 1, 159PubMedGoogle Scholar
  11. 11.
    Kannel, W. B. and McGee, D. L. (1979). Diabetes and cardiovascular risk factors: the Framingham study. Circulation, 59, 8PubMedGoogle Scholar
  12. 12.
    Pell, S. and D’Alonzo, C. A. (1970). Factors associated with long-term survival of diabetes. J. Am. Med. Assoc., 214, 1833CrossRefGoogle Scholar
  13. 13.
    Ostrander, L. D., Lamphiear, D. E., Carman, W. J. and Williams, G. W. (1981). Blood glucose and risk of coronary disease. Arteriosclerosis, 1, 33PubMedCrossRefGoogle Scholar
  14. 14.
    Goodkin, G. (1975). Mortality factors in diabetes. A 20 year mortality study. J. Occup. Med., 17, 716PubMedGoogle Scholar
  15. 15.
    Jarrett, R. J., Keen, H., Fuller, J. H. and McCartney, M. (1977). Treatment of borderline diabetes: controlled trial using carbohydrate restriction and phenformin. Br. Med. J., 2, 861PubMedCrossRefGoogle Scholar
  16. 16.
    Fuller, J. H., Shipley, M. J., Rose, G., Jarrett, R. J. and Keen, H. (1980). Coronary- heart-disease risk and impaired glucose tolerance. Lancet, 1, 1373PubMedCrossRefGoogle Scholar
  17. 17.
    Gordon, T. and Kannel, W. B. (1972). Predisposition to atherosclerosis in the head, heart, and legs. The Framingham study. J. Am. Med. Assoc., 221, 661CrossRefGoogle Scholar
  18. 18.
    Armstrong, B. and Doll, R. (1975) Bladder cancer mortality in diabetics in, relation to saccharin consumption and smoking habits. Br. J. Prev. Soc. Med., 29, 73PubMedGoogle Scholar
  19. 19.
    Czyzyk, A. and Krolewski, A. S. (1976). Is cigarette smoking more frequent among insulin treated diabetics? Diabetes, 25, 717PubMedCrossRefGoogle Scholar
  20. 20.
    Pyke, D. A. and Please, N. W. (1957). Obesity, parity and diabetes. J. Endocrinol., 15, xxviPubMedGoogle Scholar
  21. 21.
    Reinheimer, W., Bliffen, G., McCoy, J., Wallace, D. and Albrink, M. J. (1967). Weight gain, serum lipids and vascular disease in diabetics. Am. J. Clin. Nutr., 20, 986PubMedGoogle Scholar
  22. 22.
    Santen, R. J., Willis, P. W. and Fajans, S. S. (1972). Atherosclerosis in diabetes mellitus. Arch. Intern. Med., 130, 833PubMedCrossRefGoogle Scholar
  23. 23.
    Bagdade, J. D., Bierman, E. L. and Porte, D. Jr. (1971). Influence of obesity on the relationship between insulin and triglyceride levels in endogenous hypertriglyceridemia. Diabetes, 20, 664PubMedGoogle Scholar
  24. 24.
    Montoye, H. J., Epstein, F. H. and Kjelsberg, M. O. (1966). Relationship between serum cholesterol and body fatness, an epidemiological study. Am. J. Clin. Nutr., 18, 397PubMedGoogle Scholar
  25. 25.
    Nestel, P. J., Whyte, H. M. and Goodman, D. S. (1969). Distribution and turnover of cholesterol in humans. J. Clin. Invest., 48, 982PubMedCrossRefGoogle Scholar
  26. 26.
    Miettinen, T. A. (1971). Cholesterol production in obesity. Circulation, 44, 842PubMedGoogle Scholar
  27. 27.
    Kannel, W. B., Brand, N., Skinner, J. J., Dawber, T. R. and McNamara, P. M. (1967). The relation of adiposity to blood pressure and development of hypertension. The Framingham study. Ann. Intern. Med., 67, 48PubMedGoogle Scholar
  28. 28.
    Chiang, B. N., Perlman, L. V. and Epstein, F. H. (1969). Overweight and hypertension. Circulation, 39, 403PubMedGoogle Scholar
  29. 29.
    Bierman, E. L. (1979). Carbohydrate and sucrose intake in the causation of atherosclerotic heart disease, diabetes mellitus and dental caries. Am. J. Clin. Nutr., 32, 2644PubMedGoogle Scholar
  30. 30.
    Medalie, J. H., Papier, C., Herman, J. B. et al. (1974). Diabetes mellitus among 10,000 adult men. I. Five year incidence and associated variables. Israel j. Med. Sci., 10, 681PubMedGoogle Scholar
  31. 31.
    Ahrens, E. H. (1979). Dietary fats and coronary heart disease: unfinished business. Lancet, 2, 1345PubMedCrossRefGoogle Scholar
  32. 32.
    Albrink, M. J., Lavietes, P. H. and Man, E. B. (1963). Vascular disease and serum lipids in diabetes mellitus. Ann. Intern. Med., 58, 305PubMedGoogle Scholar
  33. 33.
    Ahrens, E. H., Hirsch, J., Oette, K., Farquhar J. W. and Stein, Y. (1961). Carbohydrate- induced and fat-induced lipemia. Trans. Assoc. Am. Phys., 74, 134PubMedGoogle Scholar
  34. 34.
    Bierman, E. L. and Hamlin, J. T. (1961). The hyperlipemic effect of a low-fat, high carbohydrate diet in diabetic subjects. Diabetes, 10, 432PubMedGoogle Scholar
  35. 35.
    Stone, D. B. and Connor, W. E. (1963). The prolonged effects of a low cholesterol, high carbohydrate diet upon the serum lipids in diabetic patients. Diabetes, 12, 127PubMedGoogle Scholar
  36. 36.
    Antonis, A. and Bersohn, I. (1961). The influence of diet on serum triglycerides. Lancet, 1, 3PubMedCrossRefGoogle Scholar
  37. 37.
    Simpson, R. W., Mann, J. I., Eaton, J., Moore, R. A., Carter, R. and Hockaday, T. D. R. (1978). Improved glucose control in maturity-onset diabetes treated with high- carbohydrate-modified fat diet. Br. Med. J., 1, 1753CrossRefGoogle Scholar
  38. 38.
    Simpson, R. W., Mann, J. I., Eaton, J., Carter, R. D. and Hockaday, T. D. R. (1979). High-carbohydrate diets and insulin-dependent diabetics. Br. Med. J., 2, 523PubMedCrossRefGoogle Scholar
  39. 39.
    Brunzell, J. D., Lerner, R. L., Hazzard, W. R., Porte, D., Jr and Bierman, E. L. (1971). Improved glucose tolerance with high carbohydrate feeding in mild diabetes. N. Engl. I. Med., 284, 521CrossRefGoogle Scholar
  40. 40.
    Brunzell, J. D., Lerner, R. L., Porte, D., Jr and Bierman, E. L. (1974). Effect of a fat- free, high carbohydrate diet on diabetic subjects with fasting hyperglycemia. Diabetes, 23, 138PubMedGoogle Scholar
  41. 41.
    Keen, H. and Jarrett, R. J. (1973). Macroangiopathy — its prevalence in asymptomatic diabetes. Adv. Metab. Dis., Suppl 2, 3–9Google Scholar
  42. 42.
    Vranic, M. and Berger, M. (1979). Exercise and diabetes mellitus. Diabetes, 28, 147PubMedGoogle Scholar
  43. 43.
    Morris, J. N., Everitt, M. G., Pollard, R. and Chave, S. P. W. (1980). Vigorous exercise in leisure-time: protection against coronary heart disease. Lancet, 2, 1207PubMedCrossRefGoogle Scholar
  44. 44.
    Lindgarde, F. and Saltin, B. (1981). Daily physical activity, work capacity and glucose tolerance in lean and obese normoglycaemic middle-aged men. Diabetologia, 20, 134PubMedCrossRefGoogle Scholar
  45. 45.
    Bern, M. M. (1978). Platelet functions in diabetes mellitus. Diabetes, 27, 342PubMedGoogle Scholar
  46. 46.
    Colwell, J. A., Lopes-Virella, M. and Halushka P. V. (1981). Pathogenesis of atherosclerosis in diabetes mellitus. Diabetes Care, 4, 121PubMedCrossRefGoogle Scholar
  47. 47.
    Halushka, P. V., Lurie, D. and Colwell, J. A. (1977). Increased synthesis of prostaglandin E-like material by platelets from patients with diabetes mellitus. N. Engl. J. Med., 297, 1306PubMedCrossRefGoogle Scholar
  48. 48.
    Moncada, S. and Vane, J. R. (1979). Arachidonic acid metabolities and the interactions between platelets and blood-vessel walls. N. Engl. J. Med., 300, 1142PubMedCrossRefGoogle Scholar
  49. 49.
    Halushka, P. V., Rogers, R. C., Loadholt, C. B. and Colwell, J. A. (1981). Increased platelet thromboxane synthesis in diabetes mellitus. J. Lab. Clin. Med., 97, 87PubMedGoogle Scholar
  50. 50.
    Ziboh, V. A., Maruta, H., Lord, J., Cagle, W. D. and Lucky, W. (1979). Increased biosynthesis of thromboxane A2 by diabetic platelets. Eur. I. Clin. Invest., 9, 223CrossRefGoogle Scholar
  51. 51.
    Betteridge, D. J., Zahavi, J., Jones, N. A. G., Shine, B., Kakkar, V. V. and Galton, D. J. (1981). Platelet function in diabetes mellitus in relationship to complications, glycosylated haemoglobin and serum lipoproteins. Eur. J. Clin. Invest., 11, 273PubMedCrossRefGoogle Scholar
  52. 52.
    Silberbauer, K., Schernthaner, G., Sinzinger, H., Piza-Katzer, H. and Winter, M. (1979). Decreased vascular prostacyclin in juvenile-onset diabetes. N. Engl. J. Med., 300, 366PubMedGoogle Scholar
  53. 53.
    Johnson, M., Harrison, H. E., Raftery, A. T. and Elder, J. B. (1979). Vascular prostacyclin may be reduced in diabetes in man. Lancet, 1, 325PubMedCrossRefGoogle Scholar
  54. 54.
    Davis, T. M. E., Bown, E., Finch, D. R., Mitchell, M. D. and Turner, R. C. (1981). In- vitro venous prostacyclin production, plasma 6-keto-prostaglandin f concentrations, and diabetic retinopathy. Br. Med. J., 282, 1259CrossRefGoogle Scholar
  55. 55.
    Davis, T. M. E., Mitchell, M. D. and Turner, R. C. (1979). Prostacyclin and thromboxane metabolites in diabetes. Lancet, 2, 789PubMedCrossRefGoogle Scholar
  56. 56.
    Doliery, C. T., Friedman, L. A., Hensby, C. N. et al. (1979). Circulating prostacyclin may be deduced in diabetes. Lancet, 2, 1365CrossRefGoogle Scholar
  57. 57.
    Davis, T. M. E., Mitchell, M. D., Dornan, T. L. and Turner, R. C. (1980). Plasma-6-keto- PGF concentrations and diabetic retinopathy. Lancet, 1, 373PubMedCrossRefGoogle Scholar
  58. 58.
    Yikorkala, O., Kaila, J. and Viinikka, L. (1981). Prostacyclin and thromboxane in diabetes. Br. Med. J., 283, 1148CrossRefGoogle Scholar
  59. 59.
    Ross, R. and Vogel, A. (1978). The platelet-derived growth factor. Cell, 14, 203PubMedCrossRefGoogle Scholar
  60. 60.
    O’Sullivan, J. B., Cosgrove, J. and McCaughan, D. (1968). Blood sugars, vascular abnormalities and survival. The Oxford study after 17 years. Postgrad. Med. J., 44, 955Google Scholar
  61. 61.
    Prosnitz, L. R. and Mandell, G. L. (1967). Diabetes mellitus among Navajo and Hopi Indians: the lack of vascular complications. Am. J. Med. Sci., 253, 700PubMedCrossRefGoogle Scholar
  62. 62.
    West, K. M. (1974). Diabetes in American Indians and other native populations in the New World. Diabetes, 23, 841PubMedGoogle Scholar
  63. 63.
    Ingelfinger, J. A., Bennett, P. H., Liebow, I. M. and Miller, M. (1976). Coronary heart disease in the Pima Indians. Diabetes, 25, 561PubMedCrossRefGoogle Scholar
  64. 64.
    Goldstein, S., Littlefield, J. W. and Soeldner, J. S. (1969). Diabetes mellitus and aging: diminished plating efficiency of cultured human fibroblasts. Proc. Natl. Acad. Sci., 64, 155PubMedCrossRefGoogle Scholar
  65. 65.
    Vracko, R. and Benditt, E. P. (1975). Restricted replicative life-span of diabetic fibroblasts in vitro: its relation to microangiopathy. Fed. Proc., 34, 68PubMedGoogle Scholar
  66. 66.
    Goldstein, S., Moerman, S. J., Soeldner, J. S., Gleason, R. E. and Barnett, D. M. (1978). Chronologic and physiologic age affect replicative lifespan of fibroblasts from diabetic, prediabetic and normal donors. Science, 199, 781PubMedCrossRefGoogle Scholar
  67. 67.
    Rowe, D. W., Scarman, B. J., Fujimoto, W. J. and Williams, R. H. (1977). Abnormalities in proliferation and protein synthesis in skin fibroblast cultures from patients with diabetes mellitus. Diabetes, 26, 284PubMedCrossRefGoogle Scholar
  68. 68.
    Eckel, R. H. and Fujimoto, W. Y. (1981). Insulin-stimulated glucose uptake, leucine incorporation into protein, and uridine incorporation into RNA in skin fibroblast cultures from patients with diabetes mellitus. Diabetologia, 20, 186PubMedCrossRefGoogle Scholar
  69. 69.
    Schnider, S. L. and Kohn, R. R. (1981). Effects of age and diabetes mellitus on the solubility and nonenzymatic glycosylation of human skin collagen. J. Clin. Invest., 67, 1630PubMedCrossRefGoogle Scholar
  70. 70.
    Howard, B. V., Fields, R. M., Mott, D. M., Savage, P. J., Nagulesparan, M. and Bennett, P. H. (1980). Diabetes and cell growth — lack of differences in growth characteristics of fibroblasts from diabetic and non-diabetic Pima Indians. Diabetes, 29, 119PubMedGoogle Scholar
  71. 71.
    Chait, A., Bierman, E. L. and Albers, J. J. (1979). Low density lipoprotein receptor activity in fibroblasts cultured from diabetic donors. Diabetes, 28, 914PubMedCrossRefGoogle Scholar
  72. 72.
    Goldstein, S. (1971). Analytical review: the pathogenesis of diabetes mellitus and its relationship to biological aging. Humangenetik (Berlin), 12, 83Google Scholar
  73. 73.
    Stout, R. W. (1981). Atherosclerosis and the metabolism of the arterial wall. In Caird, F. I. and Grimley Evans, J. (eds.) Advanced Geriatric Medicin., Vol. 1, pp. 141–51. (London: Pitman)Google Scholar
  74. 74.
    Stearns, S., Schlesinger, M. J. and Rudy, A. (1947). Incidence and clinical significance of coronary artery disease in diabetes mellitus. Arch. Intern. Med., 80, 463CrossRefGoogle Scholar
  75. 75.
    Breithaupt, D. J. and Leckie, R. B. (1961). Diabetes mellitus: a study of the practicability of life insurance. Can. Med. Assoc. J., 85, 299PubMedGoogle Scholar
  76. 76.
    Ricketts, H. T. (1955). The problem of degenerative vascular disease in diabetes. Am. J. Med., 19, 933PubMedCrossRefGoogle Scholar
  77. 77.
    Bradley, R. F. and Bryfogle, J. W. (1956). Survival of diabetic patients after myocardial infarction. Am. 1. Med., 20, 207CrossRefGoogle Scholar
  78. 78.
    Liebow, I. M., Hellerstein, H. K. and Miller, M. (1955). Arteriosclerotic heart disease in diabetes mellitus. A clinical study of 383 patients. Am. I. Med., 18, 438CrossRefGoogle Scholar
  79. 79.
    Pyke, D. A. (1968). Coronary disease and diabetes. Postgrad. Med. J., 44 (Suppl.), 966Google Scholar
  80. 80.
    Downie, E. and Martin, F. I. R. (1959). Vascular disease in juvenile diabetic patients of long duration. Diabetes, 8, 383PubMedGoogle Scholar
  81. 81.
    New, M. I., Roberts, T. N., Bierman, E. L. and Reader, G. G. (1963). The significance of blood lipid alterations in diabetes mellitus. Diabetes, 12, 208PubMedGoogle Scholar
  82. 82.
    Krolewski, A. S., Czyzyk, A., Janeczko, D. and Kopczynski, J. (1977). Mortality from cardiovascular disease among diabetics. Diabetologia, 13, 345PubMedCrossRefGoogle Scholar
  83. 83.
    Kessler, I. I. (1971). Mortality experience of diabetic patients. Twenty-six year follow-up study. Am. J. Med., 51, 715PubMedCrossRefGoogle Scholar
  84. 84.
    Beach, K. W., Brunzell, J. D., Conquest, L. L. and Strandness, D. E. (1979). The correlation of arteriosclerosis obliterans with lipoproteins in insulin-dependent and noninsulin-dependent diabetes. Diabetes, 28, 836PubMedGoogle Scholar
  85. 85.
    University Group Diabetes Program (1970). A study of the effects of hypoglycaemic agents on vascular complications in patients with adult-onset diabetes. I. Design, methods and baseline results. Diabetes, 19 (suppl. 2), 747Google Scholar
  86. 86.
    University Group Diabetes Program (1970). A study of the effects of hypoglycaemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results. Diabetes, 19 (suppl. 2), 789Google Scholar
  87. 87.
    University Group Diabetes Program (1971). Effects of hypoglycaemic agents on vascular complications in patients with adult-onset diabetes. IV. A preliminary report on phenformin results. J. Am. Med. Assoc., 217, 777CrossRefGoogle Scholar
  88. 88.
    University Group Diabetes Program (1975). A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. V. Evaluation of phenformin therapy. Diabetes, 24 (suppl. 1), 65Google Scholar
  89. 89.
    Feisntein, A. R. (1971). Clinical biostatistics. VIII. An analytic appraisal of the University Group Diabetes Program (UGDP) study. Clin. Pharmacol. Ther., 12, 167Google Scholar
  90. 90.
    Keen, H., Jarrett, R. J., Ward, J. D. and Fuller, J. H. (1973). Borderline diabetics and their response to tolbutamide. Adv. Metab. Dis., suppl. 2, 521Google Scholar
  91. 91.
    Paasikivi, J. (1973). Long-term treatment of patients with abnormal intravenous glucose tolerance after myocardial infarction. Adv. Metab. Dis., suppl. 2, 533Google Scholar
  92. 92.
    Tzagournis, M. and Reynertson, R. (1972). Mortality from coronary heart disease during phenformin therapy. Ann. Intern. Med., 76, 587PubMedGoogle Scholar

Copyright information

© R. W. Stout 1982

Authors and Affiliations

  1. 1.The Queen’s University of BelfastUK

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