Abstract
According to the original theory of a simple negative feedback mechanism dependent on the action of a tissue-specific antimitotic messenger molecule, it was naturally to be expected that only one such substance would be needed in each tissue to ensure cellular homeostasis. Mitosis would develop automatically whenever the chalone concentration became inadequate, and would cease whenever the chalone concentration exceeded a certain critical level, which would occur whenever the cell mass was great enough. With the progress of chalone research, particularly on the epidermis, this simple concept quickly became untenable.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1983 W. S. Bullough
About this chapter
Cite this chapter
Bullough, W.S. (1983). The epidermal messenger molecules. In: The Dynamic Body Tissues. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6261-6_2
Download citation
DOI: https://doi.org/10.1007/978-94-011-6261-6_2
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-6263-0
Online ISBN: 978-94-011-6261-6
eBook Packages: Springer Book Archive