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Nutrition and immunity: possible new approaches to research in schizophrenia

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The Biological Basis of Schizophrenia

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Abstract

Host resistance depends upon specific immunological responses and nonspecific factors of resistance. The immunological system consists of two lymphoid components, and both components apparently arise from the same stem-cell series. Lymphocytes arising in the thymus are called T cells, (‘T’ indicating thymus), and lymphocytes arising from bone marrow are called B cells (‘B’ indicating bone marrow). T cells are responsible for cell-mediated immunity reactions such as graft rejection and delayed hypersensitivity, and B cells are responsible for the production of immunoglobulins and antibody. T and B cells and their products, along with macrophages, complement, and certain non-specific factors of resistance co-operate to provide the bulwark of host defences (Good et al., 1970). Non-specific factors of resistance include phenomena such as certain endocrine functions, serum iron, and the ability to mount appropriate febrile and leukocytosis reactions. The effect of certain hormones on the immune system can be particularly striking (Braun and Unger, 1973). Both specific and non-specific factors participate in the generation of adequate inflammatory responses.

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References

  • Braun, W. and Ungar, J. (1973). Non-specific Factors Influencing Host Resistance, (Basel: Karger)

    Google Scholar 

  • Bullen, J. J., Rogers, H. and Leigh, L. (1972). Iron-binding proteins in milk and resistance to-Escherichia coli infection in infants. Br. Med. J., 1, 69

    Article  PubMed  CAS  Google Scholar 

  • Cazzulo, L. L., Smeraldi, E. and Peuato, G. (1974). Br. J. Psychiatry, 125, 25

    Article  Google Scholar 

  • Chandra, R. K. (1975a). Reduced secretory antibody response to live attenuated measles and poliovirus vaccines in malnourished children. Br. Med. J., 2, 583

    Article  PubMed  CAS  Google Scholar 

  • Chandra, R. K. (1976). Serum complement and immunoconglutinin in malnutrition. Arch. Dis. Child., 50, 225

    Article  Google Scholar 

  • Chandra, R. K. (1977). In Food and Immunology (1977) p. 58 (L. Hambraeus, L. A. Hanson and H. McFarlane, eds.) (Stockholm: Almqvist & Wiksell)

    Google Scholar 

  • Cooms, R. R. A. (1975). In Clinical Aspects of Immunology (P. G. H. Gell, R. R. A. Coombs, and P. Lachmann, eds.) 3rd edn. pp. 761–781. (Oxford: Blackwell Scientific Publications)

    Google Scholar 

  • Dohan, F. C., Grasberger, J. C., Lowell, F. M., Johnstone, H. T. and Abergast, A. W. (1969). Br. J. Psychiatry, 115, 595

    Article  PubMed  CAS  Google Scholar 

  • Douglas, S. D. and Schopfer, K. (1974). Phagocyte function in protein-calorie malnutrition. Clin. Exp. Immunol., 17, 121

    PubMed  CAS  Google Scholar 

  • Douglas, S. D. and Schopfer, K. (1976). Host defence mechanisms in protein-energy malnutrition. Clin. Immunol. Immunopathol., 5, 1

    Article  PubMed  CAS  Google Scholar 

  • Douglas, S. D. and Faulk, W. P. (1977). In Advanced Clinical Immunology (R. A. Thompson, ed.) (London: Churchill-Livingstone)

    Google Scholar 

  • Edelman, R., Suskin, R. M., Olson, R. E. and Sirisinha, S. (1973). Mechanisms of defective delayed cutaneous hypersensitivity in children with protein-calorie malnutrition. Lancet, i, 506

    Article  Google Scholar 

  • Elin, R. J. and Wolff, S. M. (1974). The role of iron in non-specific resistance to infection induced by endotoxin. J. Immunol., 112, 737

    PubMed  CAS  Google Scholar 

  • Faulk, W. P., Mata, L. J. and Edsall, G. (1975). The effects of malnutrition on the immune response in humans: A review. Trop. Dis. Bull., 27, 89

    Google Scholar 

  • Faulk, W. P., Pinto-Paes, R. and Marigo, C. (1976). The immunological system in health and malnutrition. Proc. Nut. Soc., 35, 253

    Article  CAS  Google Scholar 

  • Goldman, A. S. and Smith, C. W. (1973). Host resistance factors in human milk. J. Pediatr., 82, 1082

    Article  PubMed  CAS  Google Scholar 

  • Good, R. A., Finstad, J. and Gatti, R. A. (1970). In Infectious Agents and Host Reistance, (S. Mudd, ed.) pp. 76–114. (Philadelphia: Saunders)

    Google Scholar 

  • Heyworth, B. Moore, D. L. and Brown, J. (1975). Depression of lymphocyte response to phyto-haemagglutinin in the presence of plasma from children with acute protein-energy malnutrition. Clin. Exp. Immunol., 22, 72

    PubMed  CAS  Google Scholar 

  • Mata, L. and Faulk, W. P. (1973). The immune response of malnourished subjects with special reference to measles. Arch. Latinoam. Nutr., 23, 345

    PubMed  CAS  Google Scholar 

  • McFarlane, H., Olusi, S. O., Adeshina, H. A., Ade-Serrano, M. A. and Osunkova, B. O. (1970). In Food and Immunology (L. Hambraeus, L. A. and H. McFarlane, eds.) pp. 23–41 (Stockholm: Almqvist and Wiksell)

    Google Scholar 

  • Moore, D. L., Heyworth, B. and Brown, J. (1974). PHA-induced lymphocytic transformation in leucocyte cultures from malarious malnourished and control Gambian children. Clin. Exp. Immunol., 17, 651

    Google Scholar 

  • Morrison, T. (1949) The Portable Chaucer, p. 203. (New York: The Viking Press)

    Google Scholar 

  • Neuman, C. G., Lawlor, G. J., Stiehm, E. R., Swedseid, M. E., Newton, C., Herbert, J., Ammann, A. J. and Jacob, M. (1975). Immunologic responses in malnourished children. Am. J. Clin. Nutr., 28, 89

    Google Scholar 

  • Richter, D. (1976). In Schizophrenia Today (D. Kemali, G. Bartholini and D. Richter, eds.). p. 71. (Oxford: Pergamon Press)

    Google Scholar 

  • Scrimshaw, N. S., Taylor, C. E. and Gordon, J. E. (1968). Interactions of nutrition and infection. WHO Monogr. Ser., 57

    Google Scholar 

  • Sirisinha, S., Edelman, R., Suskin, R., Charupatana, C. and Olsen, R. E. (1973). Complement and C3-proactivator levels in children with protein-calorie malnutrition and effect of dietary therapy. Lancet, i, 1016

    Article  Google Scholar 

  • Smythe, P. M., Brereton-Stiles, G. G., Grace, H. J., Mafovane, A., Schonland, M., Coovadia, H. M., Loening, W. E. K., Parent, M. A. and Vos, G. H. (1971). Thymolymphatic deficiency and depression of cell-mediated immunity in protein-calorie malnutrition. Lancet, ii, 939

    Google Scholar 

  • Smythies, J. R. (1975). In New Prospectives in Schizophrenia. (A. Forrest and J. Affleck, eds.) pp. 51–68 (London: Churchill Livingstone)

    Google Scholar 

  • Stiehm, E. R., Neumann, C. G., Swendserd, M. E., Lawlor, G. E. and Ferguson, A. C. (1977). In Food and Immunology (L. Hambraeus,C. A. Hanson and H. McFarlane, eds.) pp. 69–85. (Stockholm: Almqvist and Wiksell)

    Google Scholar 

  • Strober, W. (1974). In Coeliac Disease. (Leiden: Stenfert Kroese)

    Google Scholar 

  • Visakorpi, J. K. (197 7). In Food and Immunology. (edL. Hambraeus,L. A. Hanson and H. McFarlane, eds.) pp. 92–98 (Stockholm: Almqvist and Wiksell)

    Google Scholar 

  • Weinstein, W. M. (1974). Castroenterology, 66, 489

    CAS  Google Scholar 

  • Wyatt, R. J., Termini, B. A. and Davis, J. (1971). Schizophrenia Bull., 4, 11

    Google Scholar 

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Authors
  1. W. P. Faulk
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  2. J. R. Cockrell
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Editor information

Editors and Affiliations

  1. The Schizophrenia Association of Great Britain, UK

    Gwynneth Hemmings

  2. University College of North Wales Bangor, Gwynedd, Wales, UK

    W. A. Hemmings

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© 1978 MTP Press Limited

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Faulk, W.P., Cockrell, J.R. (1978). Nutrition and immunity: possible new approaches to research in schizophrenia. In: Hemmings, G., Hemmings, W.A. (eds) The Biological Basis of Schizophrenia. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6206-7_22

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  • DOI: https://doi.org/10.1007/978-94-011-6206-7_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6208-1

  • Online ISBN: 978-94-011-6206-7

  • eBook Packages: Springer Book Archive

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