Abstract
I want to consider schizophrenia as an inborn error of metabolism by comparing it with a disease in which the inborn error is already known. The disease chosen as a model for comparison is acute intermittent porphyria. Features of this disease include the presence of psychiatric symptoms, the onset of manifest disease symptoms post puberty, either an acute or chronic course, and the presence of hereditary factors’ and precipitating factors. The clinical material which has formed the basis for the comparison consists of two pedigrees, one of which has suffered from schizophrenia and the other from acute intermittent porphyria. Both families were from isolated geographical areas in Sweden, and both pedigrees have been traced back more than ten generations to the early 17 th century.
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Wetterberg, L. (1978). Clinical and biochemical manifestations of acute intermittent porphyria: A working model for schizophrenia as an inborn error of metabolism. In: Hemmings, G., Hemmings, W.A. (eds) The Biological Basis of Schizophrenia. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6206-7_2
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DOI: https://doi.org/10.1007/978-94-011-6206-7_2
Publisher Name: Springer, Dordrecht
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