Abstract
Proliferation of antigen-sensitized lymphocytes is one of the basic phenomena in the immune response. Several lines of evidence suggest that proliferation of lymphocytes is relatively sensitive to changes in purine metabolism1,2. Hereditary deficiencies in either adenosine deaminase (ADA) or purine nucleoside phosphorylase (PNP), enzymes of the pathways responsible for the degradation of purine nucleotides and nucleosides, result in severe immunodeficiency diseases leaving the functions of most other tissues almost unaffected3,4. The failure of the immune system in ADA deficiency seems to be based on the accumulation of adenosine, the substrate of ADA, or its metabolic products in the tissues3,5,6. This hypothesis is supported by the findings that exposure of normal mitogen-stimulated lymphocyte cultures to exogenous adenosine can inhibit proliferation of the cells7-9. Molecular mechanisms of this inhibition are not known, but several alternatives have been suggested, all of which can be approached experimentally9-11.
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References
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© 1979 The Society for the Study of Inborn Errors of Metabolism
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Hovi, T. (1979). Purine metabolism and the control of lymphocyte proliferation. Effects of exogenous adenosine on normal human lymphocytes. In: Güttler, F., Seakins, J.W.T., Harkness, R.A. (eds) Inborn Errors of Immunity and Phagocytosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6197-8_10
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DOI: https://doi.org/10.1007/978-94-011-6197-8_10
Publisher Name: Springer, Dordrecht
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