Abstract
When a contaminated therapeutic agent causes disease, no time should be lost in determining whether extrinsic or intrinsic contamination is the source. Extrinsic contamination, introduced while the product is in use often causes sporadic disease, but it also can cause major epidemics. By its nature, extrinsic contamination usually involves only a single institution. In contrast, intrinsic contamination, that is present when the product is received in the hospital, is a potentially far greater threat since medical supplies are often produced by a relatively few manufacturers, are distri buted quite widely, and may, therefore, affect a large number of patients in many hospitals.
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Maki, D. G., Rhame, F. S., Mackel, D. C. and Bennett, J. V. (1976). Nationwide epidemic of septicemia caused by contaminated intravenous products. I. Epidemiologie and clinical features. Am. J. Med. ,60, 471
Center for Disease Control. (1973). Septicemias associated with contaminated intravenous fluids-isconsin, Ohio. Morbid. Mortal. Weekly Rep. ,22, 99
Center for Disease Control. (1973). Follow-up on septicemias associated with contaminated intravenous fluids-nited States. Morbid. Mortal. Weekly Rep. ,22, 115
Center for Disease Control. (1973). Nosocomial Pseudomonas spp. bacteremias-Maryland. Morbid. Mortal. Weekly Rep. ,22, 265
Bennett, J. V. (1975). Presentation recorded in minutes of the Proceedings of the Panel on End-Product Sterility Testing, USP, November 25
Bennett, J. V., Scheckler, W. E., Maki, D. G. and Brachman, P. S. (1971). Current national patterns-nited States. In P. S. Brachman and T. C. Eickhoff (eds). Proceedings of the International Conference on Nosocomial Infections ,pp. 42–49. (Chicago: American Hospital Association)
Center for Disease Control. (1972). Nationwide epidemic of septicemia associated with intravenous fluid therapy: an analysis based on the CDC National Nosocomial Infections Study. National Nosocomial Infections Study, Report (Issued October 1972), p. 23
Maki, D. G. and Martin, W. T. (1975). Nationwide epidemic of septicemia caused by contaminated infusion products. IV. Growth of microbial pathogens in fluids for intravenous infusion. J. Infect. Dis. ,131, 267
Goldmann, D. A., Martin, W. T. and Worthington, J. W. (1973). Growth of bacteria and fungi in total parenteral nutrition solutions. Am. J. Surg. ,126, 314
Meers, P. D., Calder, M. W., Mazhar, M. M. and Lawrie, G. M. (1973). Intravenous infusion of contaminated dextrose solution. The Devonport incident. Lancet, ii ,1189
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Dixon, R.E. (1976). Intrinsic contamination—the associated infective syndromes. In: Phillips, I., Meers, P.D., D’Arcy, P.F. (eds) Microbiological Hazards of Infusion Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6179-4_8
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DOI: https://doi.org/10.1007/978-94-011-6179-4_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-6181-7
Online ISBN: 978-94-011-6179-4
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