Abstract
Harmaline is a psychotomimetic alkaloid extracted from Banisteriopsis caapi, a Colombian liana. A recent study1 has disclosed its action as an inhibitor of various transport systems in epithelial tissues, where its mode of action differs from that of other known transport inhibitors. Thus the drug reduces both sugar and amino acid uptake by the guinea-pig intestine in vitro;furthermore1 this inhibition can be extrapolated to zero time, revealing that the effect of the drug, at least in short incubations, is on the first step of the transport process, namely the translocation of the substrate across the brush-border membrane of the enterocyte.
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References
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Sepúlveda, F.V., Robinson, J.W.L. (1976). The Influence of Harmaline on Sodium and Sodium-Dependent Transport Mechanisms. In: Robinson, J.W.L. (eds) Intestinal Ion Transport. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6156-5_8
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DOI: https://doi.org/10.1007/978-94-011-6156-5_8
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