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Effects of Aldosterone on the Colon

  • Chapter
Intestinal Ion Transport

Abstract

Principal emphasis has been laid on the actions of aldosterone on the kidney, but because of the complexity of the kidney and of its function, a precise delineation of the actions of aldosterone has been difficult to obtain. It has even been difficult to define the exact role that aldosterone plays in the sodium balance as controlled by the kidneys. Furthermore, when aldosterone is given to normal animals for a prolonged period, the renal sodium-retaining effect is only transitory and after a few days ‘escape’ occurs1,2. If however we turn to examining intestinal ionic transport, considerably more useful information about the mode of action of aldosterone can be obtained. Effects are demonstrable on both small intestinal and colonic mucosal epithelium3–9. In contrast to the kidney, there is little doubt that intestinal sodium conservation during periods of sodium depletion is largely if not entirely affected through the adrenal-aldosterone system7,10. Also when aldosterone is given for a prolonged period, there is no stimulation of ‘escape’ intestinal sodium absorption for as long as the administration is continued11,12. Despite the emphasis that has been laid upon the renal effects, therefore, it is quite conceivable that the primary role of aldosterone in sodium homeostasis may lie in the control of sodium transport across gut epithelia. In the present account, attention is only going to be devoted to colon, with a description of the results of some of our investigations in rat and in man by examining the way in which aldosterone modifies the ionic transport processes of the epithelium.

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References

  1. Relman, A. S. and Schwartz, W. B. (1952). The effect of DOCA on electrolyte balance m normal man and its relation to sodium chloride intake. Yale J. Biol. Med., 24, 540

    PubMed  CAS  Google Scholar 

  2. August, J. T., Nelson, D. H. and Thorn, G. W. (1958). Response of normal subjects to large amounts of aldosterone. J. Clin. Invest., 37, 1549

    Article  PubMed  CAS  Google Scholar 

  3. Spät, A., Suligo, M., Sture, J. and Solyom, J. (1964). Effect of aldosterone on intestinal transport of sodium and potassium in rats. Acta Physiol. Acad. Sci. Hung., 24, 465

    Google Scholar 

  4. Levitan, R. and Ingelfinger, F. J. (1965). Effect of D-aldosteronc on salt and water absorption from the intact human colon. J. Clin. Invest., 44, 801

    Article  PubMed  CAS  Google Scholar 

  5. Shields, R., Mulholland, A. T. and Elmslie, R. G. (1966). Action of aldosterone upon the intestinal transport of potassium, sodium and water. Gut, 7, 686

    Article  PubMed  CAS  Google Scholar 

  6. Cofré, G. and Crabbé, J. (1967). Active sodium transport by the colon of Bufo marinus: stimulation by aldosterone and antidiuretic hormone. J. Physiol. Lond., 188, 177

    PubMed  Google Scholar 

  7. Edmonds, C. J. and Marriott, J. C. (1967). Aldosterone and adrenalectomy on electrical PD of rat colon and on the transport of Na, K, Cl and bicarbonate. J. Endocr., 39, 517

    Article  PubMed  CAS  Google Scholar 

  8. Edmonds, C. J. and Godfrey, R. C. (1970). Electrical potentials of normal human rectum and colon; effect of aldosterone. Gut, 11, 330

    Article  PubMed  CAS  Google Scholar 

  9. Noble, H. M. and Matty, A. J. (1971). Adrenal steroids and the electrical potential of rat small intestine in vivo. J. Endocr., 49, 377

    Article  PubMed  CAS  Google Scholar 

  10. Dolman, D. and Edmonds, C. J. (1975). The effect of aldosterone and the reinin-angiotensin system on sodium, potassium and chloride transport by proximal and distal rat colon in vivo. J. Physiol. Lond., 250, 597

    PubMed  CAS  Google Scholar 

  11. Charron, R. C., Lerne, C. E., Wilson, D. R., Ing, T. S. and Wrong, O. M. (1969). The effect of adrenal steroids on stool composition as revealed by in vivo dialysis of faeces. Clin. Sci., 37, 151

    PubMed  CAS  Google Scholar 

  12. Thompson, B. D. and Edmonds, C. J. (1971). Effects of prolonged aldosterone administration on rat colon and renal electrolyte excretion. J. Endocr., 50, 163

    Article  PubMed  CAS  Google Scholar 

  13. Edmonds, C. J. (1967). Gradient of electrical PD and of sodium and potassium of the gut contents along the caecum and colon of normal and sodium-depleted rats. J. Physiol. Lond., 193, 571

    PubMed  CAS  Google Scholar 

  14. Edmonds, C. J. (1967). Transport of sodium and secretion of potassium and bicarbonate by the colon of normal and sodium-depleted rats. J. Physiol. Lond., 193, 589

    PubMed  CAS  Google Scholar 

  15. Edmonds, C. J. and Marriott, J. C. (1970). Sodium transport and short-circuit current in rat colon in vivo-, effect of aldosterone. J. Physiol. Lond., 210, 1021

    PubMed  CAS  Google Scholar 

  16. Edelman, I. S. and Fimognari, G. M. (1968). On the biochemical mechanism of action of aldosterone. Recent Prog. Horm. Res., 24, 1

    PubMed  CAS  Google Scholar 

  17. Rousseau, G. and Crabbé, J. (1972). Effects of aldosterone on RNA and protein synthesis in the toad bladder. Eur. J. Biochem., 25, 550

    Article  PubMed  CAS  Google Scholar 

  18. Crabbé, J. (1963). Site of action of aldosterone on the bladder of the toad. Nature, London, 200, 787

    Article  Google Scholar 

  19. Sharp, G. W. G. and Leaf, A. (1966). Mechanism of action of aldosterone. Physiol. Rev., 46, 593

    PubMed  CAS  Google Scholar 

  20. Gruber, W. D., Knauf, H. and Frdömter, E. (1973). The action of aldosterone on Na+ and K+ transport in the rat submaxillary main duct. Pflügers Arch., 344, 33

    Article  PubMed  CAS  Google Scholar 

  21. Wiederholt, M., Schoormans, W., Hansen, L. and Behn, C. (1974). Sodium conductance changes by aldosterone in the rat kidney. Pflügers Arch., 348, 155

    Article  PubMed  CAS  Google Scholar 

  22. Thompson, B. D. and Edmonds, C. J. (1974). Aldosterone sodium depletion and hypothyroidism on the ATPase activity of rat colonic epithelium. J. Endocr., 62, 489

    Article  PubMed  CAS  Google Scholar 

  23. Landon, E. J., Jazab, N. and Forte, L. (1966). Aldosterone and sodium-potassium-dependent ATPase activity of rat kidney membranes. Amer. J. Physiol., 211, 1050

    PubMed  CAS  Google Scholar 

  24. Jørgensen, P. L. (1972). The role of aldosterone in the regulation of (Na+ + K+) ATPase in rat kidney. J. Steroid. Biochem., 3, 181

    Article  PubMed  Google Scholar 

  25. Hill, J. H., Cortas, N. and Walser, M. (1973). Aldosterone action and sodium-and potassium-activated adenosine triphosphatase in toad bladder. J. Clin. Invest., 52, 185

    Article  PubMed  CAS  Google Scholar 

  26. Barnaby, C. F. and Edmonds, C. J. (1969). A miniature GM counter and a whole body counter for the study of potassium kinetics by rat colon. J. Physiol. Lond., 205, 647

    PubMed  CAS  Google Scholar 

  27. Dolman, D., Edmonds, C. J. and Salas-Coll, C. (1975). Effect of aldosterone on lithium permeability of rat colon mucosa. J. Endocr. (In press)

    Google Scholar 

  28. Zerahn, K. (1955). Studies on the active transport of lithium in the isolated frog skin. Acta Physiol. Scand., 33, 347

    Article  PubMed  CAS  Google Scholar 

  29. Skou, J. C. (1957). The influence of some cations on an adenosine triphosphatase from peripheral nerves. Biochim. Biophys. Acta, 23, 394

    Article  PubMed  CAS  Google Scholar 

  30. Keynes, R. D. and Swan, R. C. (1959). The permeability of frog muscle fibres to lithium ions. J. Physiol Lond., 147, 626

    PubMed  CAS  Google Scholar 

  31. Edmonds, C. J. and Marriott, J. C. (1968). Factors influencing the electrical PD across the mucosa of rat colon. J. Physiol. Lond., 194, 457

    PubMed  CAS  Google Scholar 

  32. Archampong, E. Q. and Edmonds, C. J. (1972). Effect of luminal ions on the transepithelial electrical potential difference of human rectum. Gut, 13, 559

    Article  PubMed  CAS  Google Scholar 

  33. Edmonds, C. J. and Marriott, J. C. (1968). Electrical potential and short circuit current of an in vitro preparation of rat colon mucosa. J. Physiol. Lond., 194, 479

    PubMed  CAS  Google Scholar 

  34. Crocker, A. D. and Munday, K. A. (1970). The effect of the renin—angiotensin system on mucosal water and sodium transfer in everted sacs of rat jejunum. J. Physiol. Lond., 206, 323

    PubMed  CAS  Google Scholar 

  35. Davies, N. T. D., Munday, K. A. and Parsons, B. J. (1972). Studies on the mechanism of action of angiotensin on fluid transport by the mucosa of rat distal colon. J. Endocr., 54, 483

    Google Scholar 

  36. Munday, K. A. and Parsons, B. J. (1971). The action of angiotensin on sodium and fluid transport. In Glaxo Symposium on Transport Across the Intestine ed. Burland, W. L. and Samuel, P. D. p. 59 (Edinburgh and London: Churchill Livingstone)

    Google Scholar 

  37. Edmonds, C. J. and Marriott, J. C. (1967). The effect of aldosterone and adrenalectomy on the electrical potential difference of rat colon and on the transport of sodium, potassium, chloride and bicarbonate. J. Endocr., 39, 517

    Article  PubMed  CAS  Google Scholar 

  38. Barry, R. J. C., Smyth, D. H. and Wright, E. M. (1965). Short-circuit current and sodium transfer by rat jejunum. J. Physiol. Lond., 181, 410

    PubMed  CAS  Google Scholar 

  39. Binder, H. J. and Rawlins, C. L. (1973). Electrolyte transport across isolated large intestinal mucosa. Amer. J. Physiol., 225, 1232

    PubMed  CAS  Google Scholar 

  40. Ude, J. F. (1973). Relationships between fluid, sodium and non-electrolyte transfer in the rat small intestine. Ph.D. Thesis, Sheffield University

    Google Scholar 

  41. Bolton, J. E., Munday, K. A., Parsons, B. J. and York, B. (1975). Effects of angiotensin II on fluid transport, transmural potential difference and blood flow by rat jejunum in vivo. J. Physiol. Lond. (In press)

    Google Scholar 

  42. Bonjour, J. P. and Malvin, R. L. (1969). Renal extraction of PAH, GFR and UNaVin the rat during infusion of angiotensin. Amer. J. Physiol., 216, 554

    PubMed  CAS  Google Scholar 

  43. Davies, N. T. D., Munday, K. A. and Parsons, B. J. (1970). The effect of angiotensin on rat intestinal fluid transfer. J. Endocr., 48, 39

    Article  PubMed  CAS  Google Scholar 

  44. Bolton, J. E., Munday, K. A., Parsons, B. J. and Poat, J. A. (1974). Effects of angiotensin on fluid transport by rat jejunum in vivo. J. Physiol. Lond., 241, 33p

    Google Scholar 

  45. Bolton, J. E., Munday, K. A. and Parsons, B. J. (1974). The effects of angiotensin on fluid transport and blood flow in rat jejunum. J. Physiol. Lond., 244, 27p

    Google Scholar 

  46. Munday, K. A., Parsons, B. J. and Poat, J. A. (1972). Studies on the mechanism of action of angiotensin on ion transport by kidney cortex slices. J. Physiol. Lond., 224, 195

    PubMed  CAS  Google Scholar 

  47. Bolton, J. E., Munday, K. A., Parsons, B. J. and York, B. G. (1974). The non-electrogenic nature of angiotensin-stimulated sodium transport. J. Endocr., 63, 39P

    Article  Google Scholar 

  48. Levens, N. R., Munday, K. A. and York, B. (1975). The effect of angiotensin II on fluid transport, transmural PD and resistance in the rat distal colon in vivo. J. Endocr. (In press)

    Google Scholar 

  49. Edmonds, C. J. and Marriott, J. (1970). Sodium transport and short-circuit current in rat colon in vivo and the effect of aldosterone. J. Physiol. Lond., 210, 1021

    PubMed  CAS  Google Scholar 

  50. Turnberg, L. A., Isaacs, P. E. T., Corbett, C. L. and Riley, A. R. (1975). In vitro behaviour of human jejunum and ileum: response to theophylline and acetylcholine. This proceedings p. 339

    Google Scholar 

  51. McColl, I., Field, M. and Silen, W. (1968). Stimulation of electrical absorption from the ileum by epinephrine and norepinephrine. Gastroenterology, 54, 1255

    Google Scholar 

  52. Frizzell, R. A., Nellans, H. N., Acheson, L. A. and Schultz, S. G. (1973). The effects of cycloheximide on influx across the brush border of rabbit small intestine. Biochim. Biophys. Acta, 291, 302

    Article  PubMed  CAS  Google Scholar 

  53. James, W. P. T., Alpers, D. M., Gerber, J. E. and Isselbacher, K. J. (1971). The turnover of disaccharidases and brush-border proteins in rat intestine. Biochim. Biophys. Acta, 230, 194

    Article  PubMed  CAS  Google Scholar 

  54. Turnberg, L. A., Bieberdorf, F. A., Morawski, S. G. and Fordtran, J. S. (1970). Interrelationships of chloride, bicarbonate, sodium and hydrogen transport in the human ileum. J. Clin. Invest., 49, 557

    Article  PubMed  CAS  Google Scholar 

  55. Nellans, H. N., Frizzell, R. A. and Schultz, S. G. (1973). Coupled sodium chloride influxes across brush border of rabbit ileum. Amer. J. Physiol., 225, 467

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Medical Research Council, Clinical Research Centre, Watford Road, Harrow, Middlesex, UK

    C. J. Edmonds

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Editors and Affiliations

  1. Département de Chirurgie Expérimentale, Hôpital Cantonal Universitaire, Lausanne, Switzerland

    J. W. L. Robinson

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© 1976 MTP Press Ltd

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Edmonds, C.J. (1976). Effects of Aldosterone on the Colon. In: Robinson, J.W.L. (eds) Intestinal Ion Transport. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6156-5_14

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  • DOI: https://doi.org/10.1007/978-94-011-6156-5_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6158-9

  • Online ISBN: 978-94-011-6156-5

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