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Pathway of Sodium Moving from Blood to Intestinal Lumen under Influence of Oxyphenisatin and Deoxycholate

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Intestinal Ion Transport

Abstract

Laxatives of the diphenolic type and dihydroxy bile acids do not only inhibit the absorption of water and sodium from the intestine but cause a net transfer of fluid and electrolytes into the intestinal lumen. This was shown by Forth et al.1,2 for the rat colon and by Mekhjian et al. 3for the human colon using bile acids. Ewe and Hdölker4 confirmed these results with respect to bisacodyl, a diphenolic laxative, in the human colon. The transferred fluid contains sodium and chloride at the same concentrations as blood plasma3,5,6.

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References

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Author information

Authors and Affiliations

  1. Institut für Pharmakologie und Toxikologie, Universität des Saarlandes, Homburg, Germany

    G. Nell, W. Forth, W. Rummel & R. Wanitschke

Authors
  1. G. Nell
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  2. W. Forth
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  3. W. Rummel
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  4. R. Wanitschke
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Editor information

Editors and Affiliations

  1. Département de Chirurgie Expérimentale, Hôpital Cantonal Universitaire, Lausanne, Switzerland

    J. W. L. Robinson

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© 1976 MTP Press Ltd

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Nell, G., Forth, W., Rummel, W., Wanitschke, R. (1976). Pathway of Sodium Moving from Blood to Intestinal Lumen under Influence of Oxyphenisatin and Deoxycholate. In: Robinson, J.W.L. (eds) Intestinal Ion Transport. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6156-5_10

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  • DOI: https://doi.org/10.1007/978-94-011-6156-5_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6158-9

  • Online ISBN: 978-94-011-6156-5

  • eBook Packages: Springer Book Archive

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