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The Measurement of Intelligence pp 440–471Cite as

Effects of Heredity and Environment on Brain Chemistry, Brain Anatomy, and Learning Ability in the Rat1

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Abstract

Why does a researcher in animal behavior and physiology presume to address a group interested in mental retardation? In my own case, at least, it is certainly not because I bring solutions to the problems in this field. Rather it is because I believe that only a broad attack on understanding of the physiology of learning will eventually provide knowledge applicable to many questions about learning, including those of mental retardation. Believing this, I would like to tell you about some research underway on the physiology of learning, while cautioning you against expecting early applications to mental retardation. Although this research was not undertaken with retardation in mind, I am happy to be able to describe it here, and I look forward to your comments and reactions.

This research was supported in part by grants from U.S. Public Health Service, Surgeon General’s Office, and National Science Foundation. It also received aid from the U.S. Atomic Energy Commission

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Bibliography

  • Anderson, E. E. Interrelationship of Drives in the Male Albino Rat. II. Intercorrelations between 47 Measures of Drives and Learning. Comp. Psychol. Monogr., 1938, 14, 1–119.

    Google Scholar 

  • Bennett, E. L., Rosenzweig, M. R., Krech, D., Karlsson, H., Dye, N., & Ohlander, A. Individual, Strain and Age Differences in Cholinesterase Activity of the Rat Brain. J. Neurochem., 1958, 3, 144–152.

    Article  PubMed  CAS  Google Scholar 

  • Bennett, E. L., Rosenzweig, M. R., Krech, D., Ohlander, A., & Morimoto, H. Cholinesterase Activity and Protein Content of Rat Brain. J. Neurochem., 1962, 6, 210–218.

    Article  Google Scholar 

  • Bennett, E. L., Krech, D., & Rosenzweig, M. R. Effects of Environmental Complexity and Training on Acetylcholinesterase and Cholinesterase Activity in Rat Brain. Fed. Proc, 1963, 22, 334. (Abstract)

    Google Scholar 

  • Boell, E. J., Greenfield, P., & Shen, S. C. Development of Cholinesterase in the Optic Lobes of the Frog (Rana pipiens). J. Exp. Zool., 1955, 129, 415–451.

    Article  Google Scholar 

  • Briggs, M. H. & Kitto, G. B. The Molecular Basis of Memory and Learning. Psychol. Rev., 1962, 69, 537–541.

    Article  PubMed  CAS  Google Scholar 

  • Burkhalter, A., Jones, M., & Featherstone, R. M. Acetylcholine-cholinesterase Relationships in Embryonic Chick Lung Cultivated in Vitro. Proc. Soc. Exp. Biol., 1957, 96, 747–750.

    PubMed  CAS  Google Scholar 

  • Burt, G. S. Strain Differences in Picrotoxin Seizure Threshold. Nature, 1962, 193, 301–302.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, R. M. & Zubek, J. P. Effects of Enriched and Restricted Early Environments on the Learning Ability of Bright and Dull Rats. Canad. J. Psychol., 1958, 12, 159–164.

    Article  PubMed  CAS  Google Scholar 

  • Diamond, M. C., Krech, D., & Rosenzweig, M. R. The Effects of an Enriched Environment on the Histology of the Rat Cerebral Cortex. J. Comp. Neurol., in press.

    Google Scholar 

  • Ellman, G. L., Courtney, K. D., Andres, V. N., Jr., & Featherstone, R. M. A New and Rapid Determination of Acetylcholinesterase Activity. Biochem. Pharmacol., 1961, 7, 88–95.

    Article  PubMed  CAS  Google Scholar 

  • Freedman, A. M., Willis, A., & Himwich, H. E. Correlation between Signs of Toxicity and Cholinesterase Level of Brain and Blood during Recovery from Di-isopropyl Fluorophosphate (DFP) Poisoning. Amer. J. Physiol., 1949, 157, 80–87.

    PubMed  CAS  Google Scholar 

  • Geiger, R. S. & Stone, W. G. Demonstration of the Presence of Cholinesterases in Long-term Cultures and Subcultures of Adult Mammalian Brain Cells. Fed. Proc, 1962, 21, 366. (Abstract)

    Google Scholar 

  • Hamilton, J. A. The Association between Brain Size and Maze Ability in the White Rat. Unpublished Ph.D. thesis, Univ. Calif., 1935.

    Google Scholar 

  • Hebb, D. O. The Organization of Behavior. New York: Wiley, 1949.

    Google Scholar 

  • Heron, W. T. The Inheritance of Maze Learning Ability in Rats. J. Comp. Psychol., 1935, 79, 77–89.

    Article  Google Scholar 

  • Heron, W. T. The Inheritance of Brightness and Dullness in Maze Learning Ability in the Rat. J. Genet. Psychol., 1941, 59, 41–49.

    Google Scholar 

  • Hunt, J. McV. Intelligence and Experience. New York: Ronald Press, 1961.

    Google Scholar 

  • International Union of Biochemistry. Report of the Commission on Enzymes. New York: Pergamon Press, 1961.

    Google Scholar 

  • Kirk, S. A. Early Education of the Mentally Retarded. Urbana, Ill.: Univer. of Illinois Press, 1958.

    Google Scholar 

  • Koelle, G. B. A New General Concept of the Neurohumoral Functions of Acetylcholine and Acetylcholinesterase. J. Pharmacy Pharmacol., 1962, 14, 65–90.

    Article  CAS  Google Scholar 

  • Krech, D., Rosenzweig, M. R., & Bennett, E. L. Effects of Environmental Complexity and Training on Brain Chemistry. J. Comp. Physiol. Psychol., 1960, 53, 509–519.

    Article  PubMed  CAS  Google Scholar 

  • Krech, D., Rosenzweig, M. R., & Bennett, E. L. Relations between Brain Chemistry and Problem-solving, among Rats Raised in Enriched and Impoverished Environments. J. Comp. Physiol. Psychol., 1962, 55, 801–807.

    Article  PubMed  CAS  Google Scholar 

  • Krech, D., Rosenzweig, M. R., & Bennett, E. L. Effects of Complex Environment and Blindness on Rat Brain. Archives of Neurology, 1963, 8, 403–412.

    Article  Google Scholar 

  • Krechevsky, I. Hereditary Nature of “Hypotheses.” J. Comp. Psychol., 1933, 16, 99–116.

    Article  Google Scholar 

  • Krechevsky, I. Brain Mechanisms and Variability: I. Variability within a Means-end-readiness. J. Comp. Psychol., 1937, 23, 121–138.

    Article  Google Scholar 

  • McGaugh, J. L., Westbrook, W., & Burt, G. Strain Differences in the Facultative Effects of 5–7-diphenyl-l-3-diazadamantan-6–01 (1757 I.S.) on Maze Learning. J. Comp. Physiol. Psychol., 1961, 54, 502–505.

    Article  Google Scholar 

  • McGaugh, J. L., Westbrook, W. H., & Thomson, C. W. Facilitation of Maze Learning with Posttrial Injections of 5–7-diphenyl-l-3-diazadamantan-6–01 (1757 I.S.). J. Comp. Physiol. Psychol., 1962, 55, 710–713.

    Article  Google Scholar 

  • Pepler, W. J. & Pearse, A. G. E. The Histochemistry of the Esterases of Rat Brain, with Special Reference to Those of the Hypothalamic Nuclei. J. Neurochem., 1957, 1, 193–202.

    Article  PubMed  CAS  Google Scholar 

  • Petrinovich, L. Facilitation of Successive Discrimination Learning by Strychnine Sulphate. Psychopharmacologia, 1963,4, 103–113.

    Article  PubMed  CAS  Google Scholar 

  • Ramon y Cajal, S. Les Nouvelles Idées sur la Structure du Système Nerveux chez L’homme et chez les Vertébrés. Edition française revue et augmentée par l’auteur. (Trans, by L. Azoulay) Paris: C. Reinwald, 1895.

    Google Scholar 

  • Roderick, T. H. Selection for Cholinesterase Activity in the Cerebral Cortex of the Rat. Genetics, 1960, 45, 1123–1140.

    PubMed  CAS  Google Scholar 

  • Rose, J. E., Malis, L. I., & Baker, C. P. Neural Growth in the Cerebral Cortex after Lesions Produced by Monoenergetic Deuterons. In Rosenblith, W. A. (Ed.), Sensory Communication. Massachusetts, M.I.T. Press & New York: Wiley, 1962. Pp. 279–301.

    Google Scholar 

  • Rosenzweig, M. R., Krech, D., & Bennett, E. L. Brain Enzymes and Adaptive Behavior. In Ciba Foundation Symposium on the Neurological Basis of Behavior. London; J. & A. Churchill, 1958. Pp. 337–355.

    Google Scholar 

  • Rosenzweig, M. R., Krech, D., & Bennett, E. L. A Search for Relations between Brain Chemistry and Behavior. Psychol. Bull., 1960, 57, 476–492.

    Article  PubMed  CAS  Google Scholar 

  • Rosenzweig, M. R., Krech, D., & Bennett, E. L. Heredity, Environment, Brain Biochemistry, and Learning. Current Trends in Psychological Theory. Pittsburgh: Univer. Pittsburgh Press, 1961. Pp. 87–110.

    Google Scholar 

  • Rosenzweig, M. R., Krech, D., & Bennett, E. L. Strain Differences in Cerebral Responses to Environmental Complexity and Training. Fed. Proc, 1964, 23, 255 (Abstract).

    Google Scholar 

  • Rosenzweig, M. R., Krech, D., & Bennett, E.L. Modifying Brain Chemistry by Enrichment or Impoverishment of Experience. In Newton, G. (Ed.) Readings in Early Experience. In press.

    Google Scholar 

  • Rosenzweig, M. R., Krech, D., Bennett, E. L., & Diamond, M. C. Efíects of Environmental Complexity and Training on Brain Chemistry and Anatomy: a Replication and Extension. J. Comp. Physiol. Psychol., 1962, 55, 429–437.

    Article  PubMed  CAS  Google Scholar 

  • Rowland, G. L. & Woods, P. J. Performance of the Tryon Bright and Dull Strains under Two Conditions in a Multiple T-maze. Canad. J. Psychol., 1961, 15, 20–28.

    Article  PubMed  CAS  Google Scholar 

  • Searle, L. V. A Study of the Generality of Inherited Maze-brightness and Maze-dullness. Psychol. Bull., 1941, 38, 742. (Abstract)

    Google Scholar 

  • Searle, L. V. The Organization of Hereditary Maze-brightness and Maze-dullness. Genet. Psychol. Monogr., 1949, 39, 279–325.

    Google Scholar 

  • Silverman, W., Shapiro, F., & Heron, W. T. Brain Weight and Maze Learning in Rats. J. Comp. Psychol., 1940, 30, 279–282.

    Article  Google Scholar 

  • Smith, C. E. Is Memory a Matter of Enzyme Induction? Science, 1962, 138, 889–890.

    Article  PubMed  CAS  Google Scholar 

  • Sperti, L. & Sperti, S. Effects of Chronic Lesions of the Peduncles on Cerebellum Cholinesterase Activity, in the Albino Rat. Experientia, 1959, XV, 441.

    Article  Google Scholar 

  • Tapp, J. T. & Markowitz, H. Infant Handling: Effects on Avoidance Learning, Brain Weight, and Cholinesterase Activity. Science, 1963, 140, 486–487.

    Article  PubMed  CAS  Google Scholar 

  • Thompson, W. R. The Inheritance and Development of Intelligence. Proc. Assoc. Res. Nerv. Ment. Dis., 1954, 33, 209–231.

    CAS  Google Scholar 

  • Thomson, C. W., McGaugh, J. L., Smith, C. E., Hudspeth, W. J., & Westbrook, W. H. Strain Differences in the Retroactive Effects of Electroconvulsive Shock on Maze Learning. Canad. J. Psychol., 1961, 15, 69–74.

    Article  PubMed  CAS  Google Scholar 

  • Tolman, E. C. The Inheritance of Maze-Learning Ability in Rats. J. Comp. Psychol., 1924, 4, 1–18.

    Article  Google Scholar 

  • Tolman, E. C, Tryon, R. C., & Jeffress, L. A. A Self-recording Maze with an Automatic-delivery Table. Univ. Calif. Publ. Psychol., 1929, 4, 99–112.

    Google Scholar 

  • Tryon, R. C. Genetic Differences in Maze Learning Ability in Rats. Yearbk. Nat. Soc. Stud. Educ, 1940, 39, Part I, 111–119.

    Google Scholar 

  • Tryon, R. C. Individual Differences. In Moss, F. A. (Ed.), Comparative Psychology (revised ed.). New York: Prentice-Hall, 1942. Pp. 330–365.

    Google Scholar 

  • Tryon, R. C. Experimental Behavior Genetics of Maze Ability and a Sufficient Polygenic Theory. Amer. Psychologist, 1963, 18, 442. (Cited by title)

    Google Scholar 

  • Whalen, R. E. Strain Differences in Sexual Behavior of the Male Rat. Behavior, 1961, 18, 199–204.

    Article  Google Scholar 

  • Woods, P. J., Fiske, A. S., & Ruckelshaus, S. I. The Effects of Drives Conflicting with Exploration on the Problem-solving Behavior of Rats Reared in Free and Restricted Environments. J. Comp. Physiol. Psychol, 1961, 54, 167–169.

    Article  PubMed  CAS  Google Scholar 

  • Woolley, D. E., Timiras, P. S., Rosenzweig, M. R., Krech, D., & Bennett, E. L. Sex and Strain Differences in Electroshock Convulsions of the Rat. Nature, 1961, 190, 515–516.

    Article  PubMed  CAS  Google Scholar 

  • Woolley, D. E., Timiras, P. S., Rosenzweig, M. R., Krech, D., & Bennett, E. L. Strain Differences in Seizure Responses and Brain Cholinesterase Activity in Rats. Proc. Soc. Exp. Biol. Med., 1963, 112, 781–785.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. University of California, Berkeley, USA

    Mark R. Rosenzweig (Professor of Psychology)

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  1. Mark R. Rosenzweig
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© 1973 H. J. Eysenck

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Rosenzweig, M.R. (1973). Effects of Heredity and Environment on Brain Chemistry, Brain Anatomy, and Learning Ability in the Rat1 . In: The Measurement of Intelligence. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6129-9_28

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  • DOI: https://doi.org/10.1007/978-94-011-6129-9_28

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6131-2

  • Online ISBN: 978-94-011-6129-9

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