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Genetic and Developmental Factors as Related to Stress in Schizophrenia

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Adjustment of Schizophrenics in the Community

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Abstract

One of the strongest factors predicting the occurrence of schizophrenia and its course is genetic inheritance. Yet, clinically, this factor accounts for only 14–16% (22, 53) of the schizophrenic cases. On the other hand, environmentalists, supported by family research, claim that deviant family interaction can explain and predict the gamut of schizophrenic reactions. This chapter reviews each hypothesis in terms of the merits it holds for prediction of schizophrenia.

The research results presented in this chapter have appeared in the Articles: G. Serban: Parental stress in the development of schizophrenic offspring, Comprehensive Psyehiat. 16: 23-36, 1975 and G. Serban, and G.W. Woloshin: Relationship between pre- and postmorbid psychological stress in schizophrenics. Psychol. Rep. 35: 507–517, 1974.

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References

  1. Alanen, Y.: The family of schizophrenic patients. In “The Schizophrenic Syndrome” (J. R. Cancro, ed.) Vol. 1., Brunner-Mazel, New York, 1971.

    Google Scholar 

  2. Arieti, S.: An overview of schizophrenia from a predominantly psychological approach. Am. J. Psychiat. 131 (3), 241–249, 1974.

    PubMed  CAS  Google Scholar 

  3. Bateson, G., Jackson, D., Haley, J., and Weakland, J.: Toward a theory of schizophrenia, Behav. Sci. 1, 251–264, 1956.

    Article  Google Scholar 

  4. Beck, S.J.: “The Six Schizophrenias,” American Orthopsychiatric Assoc, New York, 1954.

    Google Scholar 

  5. Birren, J.E.: Psychological examination of children who later become psychotic, J. Clin. Psychol. 39, 84–96, 1944.

    Google Scholar 

  6. Bleuler, M.: Some results of research in schizophrenia. In “Annual Review of the Schizophrenic Syndrome” (R. Cancro, ed.), Brunner-Mazel, New York, pp. 3–16. 1971.

    Google Scholar 

  7. Bogoch, S.: Cerebrospinal fluid neuraminic acid deficiency in schizophrenia: a preliminary report. Am. J. Psychiat. 114, 172, 1957.

    PubMed  CAS  Google Scholar 

  8. Book, J.A.: A genetic and neuropsychiatric investigation of a North-Swedish population with special regard to schizophrenia and mental deficiency. Acta Genet. 4, 1, 133–345, 1953.

    PubMed  CAS  Google Scholar 

  9. Bowen, M.A.: Family Concept of schizophrenia. In “The Etiology of Schizophrenia” (John D. Jackson, ed.), pp. 346–372. Basic Books, New York.

    Google Scholar 

  10. Bower, E.M., Shellhammer, T.A., and Daily, J.M.: School Characteristics of male adolescents who later become schizophrenic. Am. J. Orthopsychiat. 30, 712–729, 1960.

    Article  Google Scholar 

  11. Cameron, N.: “Personality Development and Psychopathology,” Houghton Mifflin, Boston, 1963.

    Google Scholar 

  12. Cheek, F.E.: The schizophrenic mother in word and deed, Family Process 3, 155–177, 1964.

    Article  Google Scholar 

  13. Essen-Moller, E.: Calculation of morbid risk in parents of index cases or applied to a family of schizophrenics. Acta Genet. 5, 334–442, 1955. Basel

    PubMed  CAS  Google Scholar 

  14. Fleming, P.: Emotional antecedents of schizophrenia. Paper read before the First Conf. on Life History Research in Psychopathology. New York, N. Y. May 2, 1967.

    Google Scholar 

  15. Fleming, P.: Prediction of adult psychopathology, their early emotional experiences. Paper read before 2nd conf. on Life History Research in Psychopathology, Univ. of Minn., April 19, 1968.

    Google Scholar 

  16. Fowler, R.C., Tsuang, M.I., Cadoret, R.J., and Monnelly, E.: Non psychotic disorders in the families of process schizophrenics. Acta Psych. Scandinavica 51, 153–160, 1975.

    Article  CAS  Google Scholar 

  17. Frazee, H.E.: Children who later become schizophrenic. Smith Coll. Studies Soc. Work 23, 125–149, 1953.

    Article  Google Scholar 

  18. Friedhoff, A.J., and Van Winkle, E.: A biochemical approach to the study of schizophrenia Am. J. Psychiat. 121, 1054–1055, 1965.

    PubMed  CAS  Google Scholar 

  19. Friedlander, D.: Personality development of twenty-seven children who later became psychotic. J. Abnorm. Soc. Psychol. 40, 330–335, 1945.

    Article  Google Scholar 

  20. Fromm-Reichman, F.: Notes on the Development of Treatment of Schizophrenics by Psychoanalytic Psychotherapy. Psychiatry 11, 263–273, 1948.

    Google Scholar 

  21. Frohman, E.G.: “Biochemical Mechanism”. in “Lafayette Clinic studies on schizophrenia” (G. Tourney and J. Gottlieb, eds.) Wayne State University Press, Detroit, pp. 125–157, 1971.

    Google Scholar 

  22. Gottesman, I.I., and Shields, J.: Schizophrenia in twins: 16 years consecutive admissions to a psychiatric clinic. Brit. J. Psychiat. 112, 809–818, 1966.

    Article  PubMed  CAS  Google Scholar 

  23. Gottsman, I.I. and Shields, J.: “Schizophrenics and Genetics,” Academic Press, New York, 1972.

    Google Scholar 

  24. Hallgren, B., and Sjogren, T.: A clinical and genetico-statistical study of schizophrenia and low grade mental deficiency in a large Swedish rural population. Copenhagen: Munksgaard, 1959. Acta Psychiatrica Suppl 140, 35, 1959.

    Google Scholar 

  25. Hambert, G.: Males with Positive Sex Chromatin. Göteborg: Scandinavian University Books, 1966.

    Google Scholar 

  26. Heath, R.G., Leach, B.E., and Byers, L.W.: “Taraxein: Mode of Action. Serological Factors in Schizophrenia?” PB Hochner, Inc., New York, 1963.

    Google Scholar 

  27. Heston, L.L.: Psychiatric disorders in foster home reared children of schizophrenic mothers. Brit. J. Psychiat. 112, 819–825, 1966.

    Article  PubMed  CAS  Google Scholar 

  28. Hoffer, A., Osmond, M., and Smythies, J.: Schizophrenia: A New Approach, II, Results of a year’s research. J. Mental Sci. 100, 29–34, 1954.

    CAS  Google Scholar 

  29. Hoskins, R.G., and Pincus, G.: Sex hormone relationships in schizophrenic men. Psychosomatic Med. 11, 102–109, 1949.

    CAS  Google Scholar 

  30. Kallman, F.J.: “The Genetics of Schizophrenia.” J.J. Augustin, New York, 1938.

    Google Scholar 

  31. Kallman, F.J., and Roth, B.: Genetic aspects of preadolescent schizophrenia. Am. J. Psychiat. 112, 599–606, 1956.

    Google Scholar 

  32. Kety, S.S., Rosenthal, D., Wender, P. and Schulsinger, F.: The types and prevalence of mental illness in the biological and adoptive families of adoptive schizophrenics. In “The Transmission of Schizophrenia” (D. Rosenthal and S. Kety, eds.), pp. 345–362. Pergamon Press, Oxford. 1968.

    Google Scholar 

  33. Kety, S.S., Rosenthal, D., Wender, P.H., and Schulsinger, F.: Mental Illness in the biological and adoptive families of adopted schizophrenics. Am. J. Psychiat. 128, 302–306, 1971.

    PubMed  CAS  Google Scholar 

  34. Kuehl, F.A., Osmond, R.E., and Vanderheuval, W.J.A.: Occurrence of 3.4 dimeth oxyphenylactic acid in urines of normal and schizophrenic individuals. Nature (London) 211, 606–608, 1966.

    Article  CAS  Google Scholar 

  35. Lidz, T., Cornelison, A., Fleck, S. and Terry, D.: The intrafamilial environment of the schizophrenic patient: II. Marital schism and marital skew. Am. J. Psychiat. 114, 241–248, 1958.

    Google Scholar 

  36. Lidz, T., Cornelison, A., Terry, D. and Fleck, S.: Intrafamilial environment of the schizophrenic patient: VI. The transmission of irrationality. In “Schizophrenia and the Family. “Arch. Neurol & Psychiat., 79”, 305–316, New York, 1958.

    Google Scholar 

  37. Luxenberger, H.: Untersuchung an Schizophrenien Zweillingen und ihren Geschwistern zur Prufung der Realitat von Manifestationschwankungen. Zts. Neurol. Psychiat. 154, 351, 1936.

    Article  Google Scholar 

  38. Mednick, S.A., and Schulsinger, F.: Factors related to breakdown in children at high risk for schizophrenia. In “Life History Research in Psychopathology” (M. Roff and D. F. Rich, eds), Vol. I. pp. 51–93. Univ. of Minn. Press, Minneapolis, 1970.

    Google Scholar 

  39. Mednick, S.A., and Schulsinger, F.: Studies of children at high risk for schizophrenia. In “Schizophrenias, the First Ten Dean Award Lectures.” (S. R. Dean, ed.), M.S.S. Information Corp., New York, pp. 247–293, 1973.

    Google Scholar 

  40. Michaels, C.M., Morris, D.P., and Soroker, E.: Follow-up studies of shy withdrawn children. II. Relative incidence of schizophrenia. Am. J. Orthopsychiat. 27, 331–337, 1957.

    Article  Google Scholar 

  41. Miller, J.G.: Information input overload and psychopathology, Am. J. Psychiat. 116, 695–704, 1960.

    PubMed  CAS  Google Scholar 

  42. Morris, D.P., Soroker, E., and Burress, G.: Follow-up studies of shy withdrawn children. II. Evaluation of later adjustment. Am. J. Orthopsychiat. 24, 743–754, 1954.

    Article  PubMed  CAS  Google Scholar 

  43. Morris, H.H., Escoll, P.H., and Wexler, R.: Aggressive behavior disorders of childhood, a follow-up study. Am. J. Psychiat. 112,991–997, 1956.

    PubMed  Google Scholar 

  44. Nameche, G., Waring, M., and Ricks, D.: Early indicators of outcome in schizophrenia. J. Nerv. Ment. Dis. 139, 232–240, 1964.

    Article  PubMed  CAS  Google Scholar 

  45. O’Neal, P., and Robins, L.: Childhood patterns predictors of adult schizophrenia. A 35 year follow up of 150 subjects. Am. J. Psychiat. 115, 385–391, 1958.

    PubMed  Google Scholar 

  46. O’Neal, P., and Robins, L.: The relation of childhood behavior problems to adult psychiatric status: A 30 year follow-up study of 150 subjects. Am. J. Psychiat. 114, 961–969, 1958.

    PubMed  Google Scholar 

  47. Offord, R., and Cross, L.A.: Behavioral antecedents of adult schizophrenia: A Review. Arch. Gen. Psychiat. 21, 267–283, 1969.

    Article  PubMed  CAS  Google Scholar 

  48. Penrose, L.S.: Critical survey of schizophrenia genetics. In “Modern Perspectives in World Psychiatry” (John G. Howell, ed.), pp. 3–19. Brunner-Mazel, New York, 1971.

    Google Scholar 

  49. Pollack, M.: Comparison of childhood, adolescent and adult schizophrenics, Arch. Gen. Psychiat. 2, 652–660, 1960.

    Article  CAS  Google Scholar 

  50. Robins, L.: “Deviant Children Grow Up.” Williams & Williams, Baltimore, 1966.

    Google Scholar 

  51. Roff, M.: Childhood Social interactions and young adult psychosis. J. Clin. Psychol. 19, 152–157, 1963.

    Article  PubMed  CAS  Google Scholar 

  52. Singer, M., and Wynne, L.: Thought disorder and family relations of schizophrenics III: Methodology using projective techniques Arch. Gen. Psychiat. 12, 187–200, 1965.

    Article  PubMed  CAS  Google Scholar 

  53. Singer, M., and Wynne, L.: Thought disorder and family relations of schizophrenics: IV. Results and implications. Arch. Gen. Psychiat. 12, 201–212, 1965.

    Article  PubMed  CAS  Google Scholar 

  54. Slater, E.: A review of Earlier Concordance on Genetic Factors in schizophrenia. Proceedings of The Third World Congress of Psychiatry, Vol. 1, p. 15. Toronto Press, Montreal, 1961.

    Google Scholar 

  55. Slater, E., and Shields, J.: Psychotic and neurotic illnesses in twins. Medical Research Council Special Report Series, No. 278, London: H.M.S.O. 1953.

    Google Scholar 

  56. Vaillant, G.E. Natural history of remitting schizophrenias. Am. J. Psychiat. 120: 366–375, 1963.

    Google Scholar 

  57. Waring, M., and Ricke, D.: Family patterns of children who became adult schizophrenics. J. Nerv. Ment. Dis. 140, 351–364, 1965.

    Article  PubMed  CAS  Google Scholar 

  58. Watt, N.F., Stolorow, R.D., Lubensky, A.W., and McClelland, D.C.: School adjustment and behavior of children hospitalized for schizophrenia as adults. In “Annual Review of the Schizophrenic Syndrome” (R. Cancro, ed.), Vol. 2, pp. 359–383. Brunner-Mazel, New York, 1972.

    Google Scholar 

  59. Wittman, M.P., and Steinberg, D.L.: A study of prodromal factors in mental illness with special reference to schizophrenia, Am. J. Psychiat. 100, 811–816, 1944.

    Google Scholar 

  60. Wynne, L.C., and Singer, M.T.: Thought disorder and family relations of schizophrenics: I. Research strategy. Arch. Gen. Psychiat. 9, 191–198, 1963.

    Article  PubMed  CAS  Google Scholar 

  61. Wynne, L.C., and Singer, M.T.: Thought disorder and family relations of schizophrenics: II. Classification of forms of thinking, Arch. Gen. Psychiat. 9, 199–206, 1963.

    Article  PubMed  CAS  Google Scholar 

  62. Zuckerman, M., Oltean, M. and Monashkin, I. The parental attitude of mothers of schizophrenics. J. Consult. Psychol. 22, 4–10, 1958.

    Google Scholar 

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Authors and Affiliations

  1. New York University Medical School, USA

    George Serban M.D. (Clinical Associate Professor of Psychiatry, Principal Investigator)

  2. New York University-Bellevue Medical Center, USA

    George Serban M.D. (Clinical Associate Professor of Psychiatry, Principal Investigator)

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  1. George Serban M.D.
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© 1980 Spectrum Publications, Inc.

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Serban, G. (1980). Genetic and Developmental Factors as Related to Stress in Schizophrenia. In: Adjustment of Schizophrenics in the Community. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5921-0_7

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  • DOI: https://doi.org/10.1007/978-94-011-5921-0_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-5923-4

  • Online ISBN: 978-94-011-5921-0

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