Skip to main content
SpringerLink
Log in

Selective nutritional support for hepatic regeneration: experimental and clinical experiences with branched-chain amino acids

  • Chapter
Advances in Clinical Nutrition

Abstract

Hepatic regeneration (HR) is a transient process of the liver which occurs when liver mass is reduced by 10% or more and ceases when the initial liver mass has been restored4. The reserve capacity of this phenomenon is extraordinary since only 5% of the total liver mass (e.g. the caudate lobe) can serve to reconstitute the entire initial liver mass21. The rapidity with which this process occurs, dictates that in the second post-operative week regeneration has assumed such ‘biological priority’ as to eventually assure complete restoration of the resected mass3.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Andriguetto, P. C., Vic, P., Saint-Aubert, B., Quijano, F., M’Jahed, A., Piccolboni, D., Astre, C. and Joyeux, H. (1982). Branched-chain amino acids induce increased mitotic index in the liver of 65% hepatectomized dogs. (In preparation)

    Google Scholar 

  2. Asanuma, Y., Malchesky, P., Smith, J., Zawicki, I., Werynski, A., Carey, W., Ferguson, D., Hermann, R., Kayashima, K. and Nose, Y. (1981). Chronic ambulatory liver support by membrane plasmapheresis with on-line detoxification. Trans. Am. Soc. Artif. Int. Org., 27, 416

    CAS  Google Scholar 

  3. Blumgart, L. H., Leach, K. G. and Karran, S. J. (1971). Observations on liver regeneration after right hepatic lobectomy. Gut, 12, 292

    Google Scholar 

  4. Bucher, N. L. R. (1967). Experimental aspects of hepatic regeneration. N. Engl. J. Med., 277, 686

    Article  CAS  Google Scholar 

  5. Fischer, J. E., Funovics, J. M., Aguirre, A., James, J. H., Keane, J. M., Westorp, R. I. C., Yoshimura, N. and Westman, T. (1975). The role of plasma amino acids in hepatic encephalopathy. Surgery, 78, 276

    CAS  Google Scholar 

  6. Guidotti, G. G., Borghetti, A. F. and Gazzola, G. C. (1978). The regulation of amino acid transport in animal cells. BBA, 515, 329

    CAS  Google Scholar 

  7. Higgins, G. M. and Anderson, R. M. (1931). Experimental pathology of the liver. Restoration of the liver of the white rat following partial surgical removal. Archiv. Pathol., 12, 186

    Google Scholar 

  8. Humeau, C., Vic, P., Arnal, F., Mathieu Daude, P., Vlahovitch, B. and Sentein, P. (1980). L’activité mitotique dans les gliomes. Comparaison entre gliomes bénins et malins. Biol. Cell, 38, 3, 179

    Google Scholar 

  9. Joyeux, H., Yakoun, M., Ould-Said, H., Brissac, C. and Solassol, Cl. (1974). Regeneration hépatique après hépatectomie partielle sous nutrition parenterale. In C. Romieu, C. Solassol, H. Joyeux and B. Astruc (eds.). Proceedings of the International Congress on Parenteral Nutrition. pp. 460–479. ( Montpellier: France )

    Google Scholar 

  10. Joyeux, H., Joyeux, A., Raoux, Ph., Brissac, C., Yakoun, M., Blanc, F., Fourcade, J. and Solassol, Cl. (1977). Hepatic assistance after subtotal or total hepatectomy in the dog: a new concept. Trans. Am. Soc. Artif Int. Organs, 23, 683

    Article  CAS  Google Scholar 

  11. Joyeux, H., Joyeux, A., Raoux, Ph., Brissac, C., Blanc, F. and Solassol, Cl. (1977). Troubles métaboliques de l’anhépatie expérimentale et nutrition parentérale. Ann. Anesth. Franc. 18, 939

    CAS  Google Scholar 

  12. Joyeux, H., Joyeux, A., Ould-Said, H., Carretier, M., Yakoun, M., Brissac, C., Blanc, F. and Solassol, Cl. (1979). Artificial liver support with total parenteral nutrition after total hepatectomy in the dog. Acta Chir. Scand., 494(Suppl.), 164

    CAS  Google Scholar 

  13. Joyeux, H., Carretier, M., Ould Said, H., Saint-Aubert, B., Brissac, C., Walkin, P. and Solassol, Cl. (1980). Artificial liver in surgical hepatic insufficiency. Am. Soc. Artif. Int. Org., Abstracts 9, 73

    Google Scholar 

  14. Joyeux, H., Joyeux, A., Carretier, M., Raoux, Ph., Ould Said, H., Saint-Aubert, B., Blanc, F., Rouanet, Cl., Pujol, H. and Solassol, Cl. (1980). Suppléance hémostatique après hépatectomie totale ou subtotale chez le chien. J. Chir. Paris, 117, 199

    CAS  Google Scholar 

  15. Joyeux, H., Saint-Aubert, B., Andriguetto, P. C., M’Jahed, A., Yakoun, M., Solassol, Cl., Collet, H., Faurous, P. and Suquet, P. (1982). Evaluation de l’index pondéral hépatique (IPH), par tomoscintigraphie tridimensionnelle, au cours de la régénération hépatique après hépatectomie de 70 á 90%. Etude expérimentale et clinique. Gastroenterol. Clin. Biol. (submitted)

    Google Scholar 

  16. MacGowan, J. and Fausto, N. (1975). Ornithine decarboxylase activity and delayed DNA synthesis in the regenerating liver of protein deprived rats. Fed. Proc. 59th Annual Meeting, Abstract 3616, p. 858

    Google Scholar 

  17. Martin, D. J. (1981). Formulation of enteral feedings in hepatic insufficiency. Nutr. Support Services, 1, 34

    Google Scholar 

  18. Montecuccoli, G., Novello, F. and Stirpe, F. (1972). Effect of protein deprivation on DNA synthesis in resting and regenerating rat liver. J. Nutr., 102, 507

    CAS  Google Scholar 

  19. Quercia, R. A. (1981). Malnutrition and nutritional support in hepatic failure. Nutr. Support Services, 1, 22

    Google Scholar 

  20. Rossi-Fanelli, F., Angelico, M., Cangiano, C., Cascino, A., Capocaccia, R., Deconciliis, D., Riggio, O. and Capocaccia, L. (1981). Effect of glucose and/or branched chain amino acid infusion on plasma amino acid imbalance in chronic liver failure. J. Parent. Ent. Nutr., 5, 414

    Article  CAS  Google Scholar 

  21. Saint-Aubert, B. (1982). Limites de la Régénération Hépatique. Thése No. 77. (University of Montpellier I (School of Medicine))

    Google Scholar 

  22. Short, J., Armstrong, N. B., Gaza, D. J. and Lieberman, L. (1975). Hormones and amino acids and the control of nuclear DNA replication in liver. In R. Lesch and W. Reutter (eds.). Liver Regeneration after Experimental Injury. pp. 296–308. (New York: Stratton International Medical)

    Google Scholar 

  23. Silmes, A. M. and Dalman, P. (1974). Nucleic acid and polyamine synthesis in the rat during short term protein deficiency: response of the liver to partial hepatectomy. J. Nutr., 104, 47

    Google Scholar 

  24. Starzl, T. E. and Terblanche, J. (1979). Hepatotrophic substances. In H. Popper and F. Schaffner (eds.). Progress in liver diseases. pp. 135–151. (New York: Grune and Stratton )

    Google Scholar 

  25. Stein, W. H. and Moore, S. (1954). The free amino acids in human plasma. J. Biol. Chem., 211, 915

    CAS  Google Scholar 

  26. Stirling, G. A., Bourne, L. D. and Marsh, T. (1975). Effect of protein deprivation and a reduced diet on the regenerating rat liver. Br. J. Exp. Pathol., 56, 502

    CAS  Google Scholar 

  27. Striebel, J. P., Holm, E., Kutz, H. and Storz, L. W. (1979). Parenteral nutrition and coma therapy with amino acids in hepatic failure. J. Parent. Ent. Nutr., 3, 240

    Article  CAS  Google Scholar 

  28. Talaricio, K. S., Feller, D. D. and Neville, E. D. (1971). Mitotic response to various dietary conditions in the normal and regenerating rat liver. Proc. Soc. Exp. Biol. Med., 136, 381

    Google Scholar 

  29. Tuczeck, H. V. and Rabes, M. H. (1971). Verlust der proliferations föhigkeit der hepatozyten nach subtotaler hepatektomie. Experientia, 27, 526

    Article  Google Scholar 

  30. Vic, P. (1982). Critéres morphologiques de la régénération aprés hépatectomie. Thése de Biologie humaine. Faculté de Médecine de Montpellier

    Google Scholar 

  31. Weibel, E. R. (1969). Stereological principes for morphometry in electron microscopic cytology. Int. Rev. Cytol., 235, 26

    Google Scholar 

  32. Weinbren, K. and Woodward, E. (1964). Delayed incorporation of [32P]-orthophosphate into deoxyribonucleic acid of rat liver after subtotal hepatectomy. Br. J. Exp. Pathol., 5, 442

    Google Scholar 

  33. Weinbren, K. and Dowling, F. (1972). Hypoglycaemia and the delayed proliferative response after subtotal hepatectomy. Br. J. Exp. Pathol., 53, 78

    CAS  Google Scholar 

Download references

Authors
  1. H. Joyeux
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Saint-Aubert
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Astre
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. C. Andriguetto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Vic
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. Humeau
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Cl. Solassol
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Surgery, University of Newcastle-upon-Tyne, England

    Ivan D. A. Johnston

Rights and permissions

Reprints and permissions

Copyright information

© 1983 MTP Press Limited

About this chapter

Cite this chapter

Joyeux, H. et al. (1983). Selective nutritional support for hepatic regeneration: experimental and clinical experiences with branched-chain amino acids. In: Johnston, I.D.A. (eds) Advances in Clinical Nutrition. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5918-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-5918-0_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-5920-3

  • Online ISBN: 978-94-011-5918-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation