Abstract
The optimal utilization of nutrients with a minimum of side-effects is a basic requirement for parenteral nutrition. It has been known since 19371 that orally administered nutrients are better utilized when given simultaneously and, when protein, carbohydrates and fats are taken as a mixture, nitrogen balance is better than that observed when the same nutrients2 are taken consecutively. This is also true for parenteral nutrients, as demonstrated by Elman3 and others4–6. However, creation of a pre-mixed total parenteral nutrition (TPN) system has posed certain problems. Addition of lipid has sometimes resulted in unstable mixtures, particularly when certain electrolytes are also added. In addition, there are questions concerning storage of such mixtures.
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Hardy, G., Cotter, R., Dawe, R. (1983). The stability and comparative clearance of TPN mixtures with lipid. In: Johnston, I.D.A. (eds) Advances in Clinical Nutrition. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5918-0_20
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DOI: https://doi.org/10.1007/978-94-011-5918-0_20
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