Abstract
The administration of fat to patients receiving TPN is now gaining popularity in the United States but it has been routine in some European countries since a safe fat emulsion became available in the early sixties. Fat has been given to lower the osmolarity of TPN mixtures making possible their administration through peripheral veins1,2 or, in weekly infusions, to prevent essential fatty acid deficiency. Solassol and Joyeux3 from Montpellier introduced the concept of ‘mélange nutritif’ (nutritional mixture) in 1972. They advanced the idea that TPN solutions should be as complete and physiological as possible and suggested that all the basic nutrients could be delivered simultaneously after being mixed in a single container. They showed convincingly that fat emulsions could be incorporated into solutions containing glucose, amino acids, electrolytes and vitamins and that the resultant mixture was stable at 4 °C. A silicone U-shaped bag was designed by these authors in which all the nutrients were mixed and then infused through a central venous catheter over 12–24 h3–5. These bags have now been replaced by plastic disposable containers.
Keywords
- Parenteral Nutrition
- Total Parenteral Nutrition
- Severe Acute Pancreatitis
- Lipid Emulsion
- Intermittent Infusion
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Sitges-Serra, A., Jaurrieta, E., Pallares, R., Lorente, L., Sitges-Creus, A. (1983). Clinical experience with fat-containing TPN solutions. In: Johnston, I.D.A. (eds) Advances in Clinical Nutrition. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5918-0_18
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DOI: https://doi.org/10.1007/978-94-011-5918-0_18
Publisher Name: Springer, Dordrecht
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