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Teratogenic Mechanisms pp 19–35Cite as

Antiteratogens as analytical tools

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Part of the book series: Advances in the Study of Birth Defects ((ASBD,volume 1))

Abstract

Experimental teratology and its counterpart, the preventive avoidance of misdirected development, grew from quite distinctive roots. One had its origin in frank curiosity, i.e. Virgil’s desire of rerum cognoscere causas; the other found its starting point in the aspiration of correcting defects that had earlier been traced to deficiencies in the feeding of domestic livestock or of laboratory animals, especially of rats. It was during these latter, chiefly practical, inquiries that attention was first called to the possible importance of using the deliberate correction of aberrant developmental steps, i.e. antiteratogenesis, as an experimental tool for understanding the effects of planned intervention in normal morphogenesis.

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References

  • Beaudoin, A. R. (1961). Teratogenic activity of several closely related diazo dyes on the developing chick embryo. J. Embryol. Exp. Morphol., 9, 14

    PubMed  CAS  Google Scholar 

  • Beaudoin, A. R. (1968). The effect of citric acid on the teratogenic action of trypan blue. Life Sci., 7, I, 635

    CAS  Google Scholar 

  • Beaudoin, A. R. (1973). Teratogenic activity of 2-amino-1,3,4-thiadiazole hydrochloride in Wistar rats and the protection afforded by nicotinamide. Teratology, 7, 65

    PubMed  CAS  Google Scholar 

  • Beaudoin, A. R. (1976). NAD precursors as antiteratogens against aminothiadiazole. Teratology, 13, 95

    PubMed  CAS  Google Scholar 

  • Chamberlain, J. G. (1966), Development of cleft palate induced by 6-aminonicotinamide late in rat gestation. Anat. Rec., 156, 31

    PubMed  CAS  Google Scholar 

  • Chamberlain, J. G. (1967). Effect of acute vitamin replacement therapy on 6-aminonicotinamide-induced cleft palate late in rat pregnancy. Proc. Soc. Exp. Biol. Med., 124, 888

    PubMed  CAS  Google Scholar 

  • Chamberlain, J. G. (1975). Prevention of 6-aminonicotinamide (6-AN)-induced cleft palate in rats with pyridine nucleotide, J. Dent. Res., 54, 413

    PubMed  CAS  Google Scholar 

  • Chamberlain, J. G. and Goldyne, M. E. (1970). Intra-amniotic injection of pyridine nucleotides or adenine triphosphate as countertherapy for 6-aminonicotinamide (6-AN) teratogenesis. Teratology, 3, 11

    PubMed  CAS  Google Scholar 

  • Chamberlain, J. G. and Nelson, M. M. (1963a). Congenital abnormalities in the rat resulting from single injections of 6-aminonicotinamide during pregnancy. J. Exp. Zool., 153, 285

    PubMed  CAS  Google Scholar 

  • Chamberlain, J. G. and Nelson, M. M. (1963b) Multiple congenital abnormalities in the rat resulting from acute maternal niacin deficiency during pregnancy. Proc. Soc. Exp. Biol. Med., 112, 836

    PubMed  CAS  Google Scholar 

  • Chaube, S. (1973). Protective effects of thymidine, 5-aminoimidazole carboxamide and riboflavin against fetal abnormalities produced in rats by 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide. Cancer Res., 33, 2331

    Google Scholar 

  • Chaube, S., Kreis, W., Uchida, K. and Murphy, M. L. (1968). The teratogenic effect of 1-β-d-arabionfuranosylcytosine in the rat. Protection by deoxycitidine. Biochem. Pharmacol., 17, 1213

    PubMed  CAS  Google Scholar 

  • Chaube, S. and Murphy, M. L. (1969a). Fetal malformations produced in rats by N-isopropyl-α-(2-methylhydrazino)-p-toluamide hydrochloride (procarbazine). Teratology, 2, 23

    PubMed  CAS  Google Scholar 

  • Chaube, S. and Murphy, M. L. (1969b). Teratogenic effects of 6-hydroxylaminopurine in the rat. Protection by inosine. Biochem. Pharmacol., 18, 1147

    PubMed  CAS  Google Scholar 

  • Chaube, S. and Murphy, M. L. (1973). Protective effect of deoxycytidylic acid (CdMP) on hydroxyurea-induced malformations in rats. Teratology, 7, 79

    PubMed  CAS  Google Scholar 

  • Dagg, C. P. and Kallio, E. (1962). Teratogenic interaction of fluorodeoxyuridine and thymidine (Abstract). Anat. Rec., 142, 301

    Google Scholar 

  • Dagg, C. P., Karaofsky, D. A., Lacon, C. and Roddy, J. (1956). Comparative effects of 6-diazo-5-oxo-L-norleucine and o-diazoacetyl-L-serine on the chick embryo. Proc. Am. Ass. Cancer Res., 2, 101

    Google Scholar 

  • Deol, M. S. (1973). An experimental approach to the understanding and treatment of hereditary syndromes with congenital deafness and hypothyroidism. J. Med. Genet., 10, 235

    PubMed  CAS  Google Scholar 

  • Dyban, A. P. and Akimova, I. M. (1966). The significance of vitamin B complex and genetic factors in the reaction of rat embryos to thalidomide. Arch. Anat. Gistol. Embriol., 51, 3 (Transl.) (Nat. Lending Library for Science & Technol.)

    CAS  Google Scholar 

  • Ellison, A. C. and Maren, T. H. (1972). The effect of potassium metabolism on acetazolamide-induced teratogenesis. Johns Hopkins Med. J., 130, 105

    PubMed  CAS  Google Scholar 

  • Erway, L. C., Fraser, A. S. and Hurley, L. S. (1971). Prevention of congenital otolith defect in pallid mutant mice by manganese supplementation. Genetics, 67, 97

    PubMed  CAS  Google Scholar 

  • Erway, L. C., Hurley, L. S. and Fraser, A. (1966). Neurological defect: manganese in phenol-copy and prevention of a genetic abnormality of inner ear. Science, 152, 1766

    PubMed  CAS  Google Scholar 

  • Erway, L. C., Hurley, L. S. and Fraser, A. (1970). Congenital ataxia and otolith defects due to manganese deficiency in mice. J. Nutrition, 100, 643

    CAS  Google Scholar 

  • Erway, L. C. and Mitchell, S. E. (1973). Prevention of otolith defect in pastel mink by manganese supplementation. J. Hered., 64, 111

    PubMed  CAS  Google Scholar 

  • Ferm, V. H. (1969). The synteratogenic effect of lead and cadmium. Experientia, 25, 56

    PubMed  CAS  Google Scholar 

  • Ferm, V. H. (1970). Protective effect of ferric dextran on the embryopathie action of indium. Experienti, 26, 633

    CAS  Google Scholar 

  • Ferm, V. H. (1972). The teratogenic effect of metals on mammalian embryos. Adv. Teratol., 5, 51

    Google Scholar 

  • Ferm, V. H. and Carpenter, S. J. (1968). The relationship of cadmium and zinc in experimental mammalian teratogenesis. Lab. Invest., 18, 429

    PubMed  CAS  Google Scholar 

  • Forsthoefel, P. F. and Williams, M. L. (1975). The effects of 5-fluorouracil and 5-fluorode-oxyuridine used alone and in combination with normal nucleic acid precursors on development of mice in lines selected for low and high expression of Strong’s luxoid gene. Teratology, 11, 1

    PubMed  CAS  Google Scholar 

  • Fujii, Y. (1968). Preventative effects of protein-anabolic steroids upon the congenital defects induced by an anticarcinogen in mice. Congenital Anomalies, 8, 219

    Google Scholar 

  • Fujii, T. (1976). Mitigation of caffeine-induced fetopathy in mice by pretreatment with β-adrenergic blocking agents. Japan. J. Pharmacol., 26, 751

    CAS  Google Scholar 

  • Fujii, T. and Nishimura, H. (1974). Reduction in frequency of fetopathic effects of caffeine in mice by treatment with propranolol. Teratology, 10, 149

    PubMed  CAS  Google Scholar 

  • Greenberg, J. and LaHam, Q. N. (1969). Malathion-induced teratism in the developing chick. Canad. J. Zool., 47, 539

    CAS  Google Scholar 

  • Greenberg, J. and LaHam, Q. N. (1970). Reversal of malathion-induced teratism and its biochemical implications in the developing chick. Canad. J. Zool., 48, 1047

    CAS  Google Scholar 

  • Greene, R. M. and Kochhar, D. M. (1975). Limb development in mouse embryos: protection against teratogenic effects of 6-diazo-5-oxo-L-norleucine (DON) in vivo and in vitro. J. Embryol. Exp. Morphol., 33, 355

    PubMed  CAS  Google Scholar 

  • Grote, W., Claussen, U. and Heinz, D. (1971). Verursachung und Verhütung von Entwicklungsstörungen beim Kaninchen durch Verabreichung von 6-Aminonikotinsäureamid und Nikotinsäureamid. Arzneimittelforschung, 21, 825

    PubMed  CAS  Google Scholar 

  • Hall, B. K. (1972a). Thallium-induced achondroplasia in the embryonic chick. Dev. Biol., 28, 47

    PubMed  CAS  Google Scholar 

  • Hall, B. K. (1972b). Achondroplasia in the embryonic chick: its potentiation by Cortison acetate and alleviation by vitamin C. Canad. J. Zool., 50, 1527

    CAS  Google Scholar 

  • Hall, B. K. (1977). Thallium-induced achondroplasia in chicken embryos and the concept of critical periods during development. Teratology, 15, 1

    PubMed  CAS  Google Scholar 

  • Hamly, C.-A., Trasler, D. G. and Fraser, F. C. (1970). Reduction of 6-aminonicotinamide teratogenicity in mice by etherization. Teratology, 3, 293

    CAS  Google Scholar 

  • Hodach, R. J., Hodach, A. E., Fallon, J. F., Folds, J. D., Bruyere, H. J. and Gilbert, E. F. (1975). The role of β-adrenergic activity in the production of cardiac and aortic anomalies in chick embryos. Teratology, 12, 33

    PubMed  CAS  Google Scholar 

  • Holmberg, R. E. and Ferm, V. H. (1969). Interrelationships of selenium, cadmium and arsenic in mammalian teratogenesis. Arch. Envir. Health, 18, 873

    CAS  Google Scholar 

  • Horii, K-I. (1964). Prevention of congenital malformations in the offspring of alloxan-diabetic mice by the insulin treatment. Folia Endocrinol. Japan, 39, 988

    CAS  Google Scholar 

  • Horii, K-i, Watanabe, G-i and Ingalls, T. H. (1966). Experimental diabetes in pregnant mice. Prevention of congenital malformation in offspring by insulin. Diabetes, 15, 194

    PubMed  CAS  Google Scholar 

  • Horvath, C., Szonyi, L. and Mold, K. (1976). Preventive effect of riboflavin and ATP on the teratogenic effects of the phenothiazine derivative T-82. Teratology, 14, 167

    PubMed  CAS  Google Scholar 

  • Hurley, L. S. and Asling, G. W. (1963). Localized epiphyseal dysplasia in offspring of manganese deficient rats. Anat. Rec., 145, 25

    PubMed  CAS  Google Scholar 

  • Hurley, L. S. and Everson, G. J. (1963). Influence of timing of short-term supplementation during gestation on congenital abnormalities of manganese-deficient rats. J. Nutrition, 79, 23

    CAS  Google Scholar 

  • Hurley, L. S., Everson, G. J., Wooten, E. and Asling, C. W. (1961). Disproportionate growth of manganese-deficient rats. I. The long bones. J. Nutrition, 74, 274

    CAS  Google Scholar 

  • Hurley, L. S., Wooton, E. and Everson, G. J. (1961). Disproportionate growth in offspring of manganese deficient rats. II. Skull, brain and cerebrospinal fluid pressure. J. Nutrition, 74, 282

    CAS  Google Scholar 

  • Kalter, H. (1954). Preliminary studies on the metabolic factors involved in the production of cleft palate in mice (Abstract). Genetics, 39, 975

    Google Scholar 

  • Kalter, H. (1960). Teratogenic action of hypocaloric diet and small doses of cortisone. Proc. Soc. Exp. Biol. Med., 104, 518

    PubMed  CAS  Google Scholar 

  • Kato, T. (1973). Effect of folate metabolism-related factors on the teratogenic action of sulfonamide in mice. Congenital Anomalies, 13, 85

    Google Scholar 

  • Khan, M. A. (1975). Nicotine sulfate-induced skeletal anomalies in chick embryos (Abstract). Teratology, 11, 25A

    Google Scholar 

  • Kolesari; G. L. and Kaplan, S. (1974). The antiteratogenic effects of hypo- and hyperthermia in trypan blue-treated embryos. Dev. Biol., 38, 383

    PubMed  CAS  Google Scholar 

  • Landauer, W. (1948). The effect of nicotinamide and α-ketoglutaric acid on the teratogenic action of insulin. J. Exp. Zool., 109, 283

    PubMed  CAS  Google Scholar 

  • Landauer, W. (1949). Le problème de l’électivité dans les expériences de tératogenèse biochimique. Arch. Anat. Micros. Morph. Exp., 38, 184

    Google Scholar 

  • Landauer, W. (1952). Malformations of chicken embryos produced by boric acid and the probable role of riboflavin in their origin. J. Exp. Zool., 120, 469

    CAS  Google Scholar 

  • Landauer, W. (1953). Complex formation and chemical specificity of boric acid in production of chicken embryo malformations. Proc. Soc. Exp. Biol. Med., 82, 633

    PubMed  CAS  Google Scholar 

  • Landauer, W. (1953). On teratogenic effects of pilocarpine in chick development. J. Exp. Zool., 122, 469

    CAS  Google Scholar 

  • Landauer, W. (1957). Niacin antagonists and chick development. J. Exp. Zool., 136, 509

    PubMed  CAS  Google Scholar 

  • Landauer, W. (1960a). Experiments concerning the teratogenic nature of thallium: polyhydroxy compounds, histidine and imidazole as supplements. J. Exp. Zool., 143, 101

    PubMed  CAS  Google Scholar 

  • Landauer, W. (1960b). Nicotine-induced malformations of chicken embryos and their bearing on the phenocopy problem. J. Exp. Zool., 143, 107

    PubMed  CAS  Google Scholar 

  • Landauer, W. (1975a). Cholinomimetic teratogens: studies with chicken embryos. Teratology, 12, 125

    PubMed  CAS  Google Scholar 

  • Landauer, W. (1975b). Cholinomimetic teratogens. II. Interaction with inorganic ions. Teratology, 12, 271

    PubMed  CAS  Google Scholar 

  • Landauer, W. (1976). Cholinomimetic teratogens. III. Interaction with amino acids known as neurotransmitters. Teratology, 13, 41

    PubMed  CAS  Google Scholar 

  • Landauer, W. (1977a). Cholinomimetic teratogens. V. The effect of oximes and related Cholinesterase reactivators. Teratology, 15, 33

    PubMed  CAS  Google Scholar 

  • Landauer, W. (1977b). On teratogenic syndromes of unitary causation but heterologous systemic consequences. Acta Embryol. Exp., 3, 335

    Google Scholar 

  • Landauer, W. and Clark, E. M. (1962). The interaction in teratogenic activity of the two niacin analogs 3-acetylpyridin and 6-aminonicotinamide. J. Exp. Zool., 151, 253

    PubMed  CAS  Google Scholar 

  • Landauer, W. and Clark, E. M. (1964). On the role of riboflavin in the teratogenic activity of boric acid. J. Exp. Zool., 156, 307

    PubMed  CAS  Google Scholar 

  • Landauer, W. and Clark, E. M. (1964). On the teratogenic interaction of sulfanilamide and 3-acetylpyridine in chick development. J. Exp. Zool., 156, 313

    PubMed  CAS  Google Scholar 

  • Landauer, W. and Rhodes, M. B. (1952). Further observations on the teratogenic nature of insulin and its modification by supplementary treatment. J. Exp. Zool., 119, 221

    Google Scholar 

  • Landauer, W. and Salam, N. (1972). Aspects of dimethylsulfoxide as solvent for teratogens. Dev. Biol., 28, 35

    PubMed  CAS  Google Scholar 

  • Landauer, W. and Salam, N. (1974). The experimental production in chicken embryos of muscular hypoplasia and associated defects of beak and cervical vertebrae. Acta Embryol. Exp., 51

    Google Scholar 

  • Landauer, W. and Sopher, D. (1970). Succinate, glycerophosphate and ascorbate as sources of cellular energy and as antiteratogens. J. Embryol. Exp. Morphol., 24, 187

    PubMed  CAS  Google Scholar 

  • Landauer, W. and Wakasugi, N. (1967). Problems of acetazolamide and N-ethylnicotinamide as teratogens. J. Exp. Zool., 164, 499

    PubMed  CAS  Google Scholar 

  • Landauer, W. and Wakasugi, N. (1968). Teratological studies with sulphonamides and their implications. J. Embryol. Exp. Morphol., 20, 261

    PubMed  CAS  Google Scholar 

  • Larsson, K. S. (1977). Teratogenic mechanisms of dithiocarbamates (Abstract). Teratology, 14, 373

    Google Scholar 

  • Matthiaschk, G. (1973). Über den Einfluss von L-cystein auf die Teratogenese durch Thiram (TMTD) bei NMRI-Mäusen. Arch. Toxikol., 30, 251

    PubMed  CAS  Google Scholar 

  • Meiniel, R. (1974). Action protectrice de la pralidoxime vis-à-vis des effets tératogènes du parathion sur le squelette axial de l’embryon de caille. C.R. Acad. Sci. Paris, 279 D, 603

    Google Scholar 

  • Meiniel, R. (1975). Prévention par la pralidoxime de certains effets tératogènes induits par le bidrin chez l’embryon de caille. C.R. Acad. Sci. Paris, 280 D, 1019

    Google Scholar 

  • Meiniel, R. (1976a). Pluralité dans le déterminisme des effets tératogènes des composés organophos-phorés. Experientia, 32, 920

    PubMed  CAS  Google Scholar 

  • Meiniel, R. (1976b). Tératogenèse axiale du parathion après action de divers composés connus chez l’adulte ou l’embryon de Vertébrés pour posséder un pouvoir antitoxique ou antitératogène après des expositions aux phosphates organiques. Études chez l’embryon de caille. C.R. Acad. Sci. Paris, 283 D, 1085

    Google Scholar 

  • Meiniel, R. (1976c). Prévention des anomalies induites par deux insecticides organophosphorés (Parathion et Bidrin) chez l’embryon de caille. Arch. Anat. Micros. Morph. Exp., 65, 1

    CAS  Google Scholar 

  • Milien, J. W. and Woollam, D. H. M. (1958). Effect of vitamin B complex on the teratogenic activity of hypervitaminosis A. Nature (Lond.), 182, 940

    Google Scholar 

  • Miller, T. J. (1973). Cleft palate formation: the effects of fasting and iodoacetic acid on mice. Teratology, 7, 177

    PubMed  CAS  Google Scholar 

  • Mizutani, M., Ihara, T. and Sugitani, T. (1974). Protective effects of nicotinamide and tryptophan against the teratogenicity of N,N’-methylene-bis (2-amino-1,3,4-thiadiazole) in the hamster (Abstract). Teratology, 9, A28

    Google Scholar 

  • Mulherkar, L. S., Joshi, S., Diwan, B. A. and Joshi, P. N. (1967). Reversible effect of chloroacetophenone by sulhydryl groups on morphogenesis of chick embryos. J. Embryol. Exp. Morphol., 17, 263

    CAS  Google Scholar 

  • Mulherkar, L., Rao, K. V. and Joshi, S. S. (1965). Studies on some aspects of the role of sulfhydryl groups in morphogenesis. J. Embryol. Exp. Morphol., 14, 129

    PubMed  CAS  Google Scholar 

  • Mulherkar, L., Rao, K. V., Joshi, S. S. and Joshi, P. N. (1966). Reversible effects of chloroacetophenone on the embryos of Microhyla ornata. J.Anim. Morphol. Physiol., 13, 9

    Google Scholar 

  • Overman, D. O., Graham, M. N. and Roy, W. A. (1976). Ascorbate inhibition of 6-aminonicotinamide teratogenesis in chicken embryos. Teratology, 1, 85

    Google Scholar 

  • Persaud, T. V. N. (1967). Foetal abnormalities caused by the active principle of Blighia sapida (Ackee). W. I. Med. J., 16, 193

    Google Scholar 

  • Persaud, T. V. N. (1968). Teratogenic effects of hypoglycin-A. Nature (Lond.), 217, 471

    CAS  Google Scholar 

  • Persaud, T. V. N. (1969a). Attempts in reversing the teratogenic effects of hypoglycin-A with leucine and riboflavin (Abstract). Internat. Conf. Congenit. Malf., Excerpta Medica Intern. Congress, Ser. No. 191, 70

    Google Scholar 

  • Persaud, T. V. N. (1969b). Developmental abnormalities in the rat induced by the amino acid leucine. Naturwissenschaften, 56, 37

    PubMed  CAS  Google Scholar 

  • Persaud, T. V. N. (1970). Congenital abnormalities in relationship to the inhibition of fatty acid oxidation. Wiss. Zschr. Friedrich Schiller Univ. Jena, Math.-Nat. R., 19, 247

    Google Scholar 

  • Persaud, T. V. N. (1972). Teratogenic effect of hypoglycemia. Adv. Teratol., 5, 11

    Google Scholar 

  • Persaud, T. V. N. (1973). Prevention by leucine of hypoglycin B induced teratogenesis in the rat. Exp. Pathol., 8, 283

    CAS  Google Scholar 

  • Petter, C., Bourbon, J., Maltier, J.-P. and Jost, A. (1977). Simultaneous prevention of blood abnormalities and hereditary congenital amputation in a brachydactylous rabbit stock. Teratology, 15, 149

    PubMed  CAS  Google Scholar 

  • Pierro, L. J. (1961). Teratogenic action of actinomycin D in the embryonic chick. J. Exp. Zool., 147, 203

    PubMed  CAS  Google Scholar 

  • Proctor, N. H. and Casida, J. E. (1975). Organophosphorus and methyl carbamate insecticide teratogenesis: diminished NAD in chicken embryos. Science, 190, 580

    PubMed  CAS  Google Scholar 

  • Proctor, N. H., Moscioni, A. D. and Casida, J. E. (1976). Chicken embryo NAD levels lowered by teratogenic organophosphorus and methylcarbamate insecticides. Biochem. Pharmacol., 25, 757

    PubMed  CAS  Google Scholar 

  • Puricha, N. and Erway, L. C. (1972). Effects of dichlorphenamide, zinc and manganese on otolith development in mice. Dev. Biol., 27, 395

    Google Scholar 

  • Rao, K. V. (1969). A study of the role of sulfhydryl groups in morphogenesis of the chick embryo. Roux’ Arch. Entw. Mech., 163, 161

    Google Scholar 

  • Roger, J.-C., Upshall, D. G. and Casida, J. E. (1969). Structure—activity and metabolism studies on organophosphate teratogens and their alleviating agents in developing hen eggs with special emphasis on Bidrin. Biochem. Pharmacol., 18, 373

    PubMed  CAS  Google Scholar 

  • Rogóyski, A. (1967a). The effect of fasting combined with hydrocortisone acetate treatment on the formation of developmental disturbances of the fetus in pregnant mice. Polish Med. J., 6, 1646

    Google Scholar 

  • Rogóyski, A. (1976b). Deficient nutrition in pregnant mice as a factor conducive to developmental anomalies in the fetus after simultaneous administration of hydrocortisone acetate. Folia Morphol., 26, 313

    Google Scholar 

  • Rosenzweig, S. and Blaustein, F. (1970). Cleft palate in A/J mice resulting from restraint and deprivation of food and water. Teratology., 3, 47

    PubMed  CAS  Google Scholar 

  • Ruano Gil, D. (1967). The influence of thalidomide on the development of chick embryos cultivated in vitro. Acta Anat., 66, 226

    PubMed  CAS  Google Scholar 

  • Ruch, J. V. (1967). Effet antagoniste du D-glucose sur Faction tératogène du phosphate de dexaméthasone chez l’embryon de poulet. C.R. Soc. Biol., 161, 915

    CAS  Google Scholar 

  • Rumpler, Y. (1969). Compensation de l’action tératogène d’un antithyroidien (le 1-méthyle 2 mercapto imidazol ou Basolan) par l’administration simultanée de thyroxine à l’embryon de poulet. Bull. Assoc. Anat. 53 e Congrès, C.R. Ass. Anat., 143, 1450

    Google Scholar 

  • Runner, M. (1959). Inheritance of susceptibility to congenital deformity. Metabolic clues probided by experiments with teratogenic agents. Pediatrics, 23, 245

    PubMed  CAS  Google Scholar 

  • Runner, M. N. and Miller, J. R. (1956). Congenital deformity in the mouse as a consequence of fasting (Abstract). Anat. Rec., 124, 437

    Google Scholar 

  • Schardein, J. L., Dresner, A. J., Hentz, D. L., Petrere, J. A., Fitzgerald, J. E. and Kurtz, S. M. (1973). The modifying effect of folinic acid on diphenylhydantoin-induced teratogenicity in mice. Toxicol. Appl. Pharmacol., 24, 150

    PubMed  CAS  Google Scholar 

  • Scott, W. J., Ritter, E. J. and Wilson, J. G. (1973). DNA synthesis inhibition, cytotoxicity and their relationship to teratogenesis following administration of a nicotinamide antagonist, aminothiadiazole, to pregnant rats. J. Embryol. Exp. Morphol., 30, 257

    PubMed  CAS  Google Scholar 

  • Semba, R., Yamamura, H. and Murakami, U. (1977). Effect of cadmium pretreatment on teratogenicity and fetolethality of cadmium. Okajimas Folia Anat. Jap., 54, 283

    CAS  Google Scholar 

  • Shih, L. Y., Toliver, C. and Yang, C. S. (1974). Protective effect of ascorbic acid against cleft-palate formation in mice (Abstract). Teratology. 9, A 36

    Google Scholar 

  • Smith, P. E. and MacDowell, E. C. (1939). An hereditary anterior-pituitary deficiency in the mouse. Anat. Rec., 46, 249

    Google Scholar 

  • Snell, G. D. (1929).Dwarf, a new Mendelian recessive character in the house mouse. Proc. Nat. Acad. Science (USA), 15, 733

    CAS  Google Scholar 

  • Sudo, T. (1968). Suppressive effect of vitamin E on experimental micromelia produced by hypervitaminosis A (Japanese, English summary). Congenital Anomalies, 8, 163

    Google Scholar 

  • Sullivan, G. E. (1975). Paralysis and skeletal abnormalities in chick embryo treated with physostigmine. Austral. J. Zool., 23, 1

    CAS  Google Scholar 

  • Sullivan, G. E. and Takacs, E. (1971). Comparative teratogenicity of pyrimethamine in rats and hamsters. Teratology, 4, 205

    CAS  Google Scholar 

  • Terada, M. and Nishimura, H. (1975). Mitigation of caffeine-induced teratogenicity in mice by prior chronic caffeine ingestion. Teratology, 12, 79

    PubMed  CAS  Google Scholar 

  • Watney, M. J. and Miller, J. R. (1964). Prevention of a genetically determined congenital eye anomaly in the mouse by the administration of cortisone during pregnancy. Nature (Lond.), 202, 1029

    CAS  Google Scholar 

  • Yamaguchi, T. (1968). Effect of vitamin B12 on the incidence of malformations in the rat fetus caused by maternal hypervitaminosis A (Japanese, English summary). Congenital Anomalies, 8, 19

    Google Scholar 

  • Yasuda, M., Nanjo, H. and Suzuki, M. (1963). Teratogenic and lethal effects of fasting during pregnancy upon the offspring of elderly mice (Abstract). Proc. Cong. Anom. Res. Ass. Japan, 3, 43

    Google Scholar 

  • Zwilling, E. (1959). Micromelia as a direct effect of insulin. Evidence from in vitro and in vivo experiments. J. Morphol., 104, 159

    CAS  Google Scholar 

  • Zwilling, E. and DeBell, J. T. (1950). Micromelia and growth retardation as independent effects of sulfanilamide in chick embryos. J. Exp. Zool., 115, 59

    CAS  Google Scholar 

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  1. W. Landauer
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  1. Department of Anatomy, Faculties of Medicine and Dentistry, University of Manitoba, 730 William Avenue, R3E 0W3, Winnipeg, Manitoba, Canada

    T. V. N. Persaud

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Landauer, W. (1979). Antiteratogens as analytical tools. In: Persaud, T.V.N. (eds) Teratogenic Mechanisms. Advances in the Study of Birth Defects, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5910-4_2

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  • DOI: https://doi.org/10.1007/978-94-011-5910-4_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-5912-8

  • Online ISBN: 978-94-011-5910-4

  • eBook Packages: Springer Book Archive

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