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Antimutagenic and Antitumour Activities of Lactic Acid Bacteria

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Book cover Probiotics 2

Abstract

Epidemiological studies suggest that around one-third of all human cancers are related to the diet (Doll and Peto, 1981). Many studies on the presence of natural mutagens, antimutagens and cancer-modulating compounds as inherent factors of our food have been published in the last decade (Ahmed, 1992; Norred and Voss, 1994). At one time it was the opinion in cancer research that there was no relationship between carcinogens and mutagens, but reports that 4-nitroquinoline-N-oxide (4NQO), a carcinogen, also had the property of inducing spontaneous mutation in bacteria, and that N-methyl-N’-nitro-nitrosoguanidine (MNNG), a known mutagen, also induced stomach cancer, led inexorably to the conclusion that there is a close relationship between the two, and today it is clear that 85% of carcinogens are mutagenic (Sugimura, 1982). This indicates that there may be a steady increase in substances combining mutagenicity and carcinogenicity in our surroundings.

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Authors
  1. A. Hosono
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  2. H. Kitazawa
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  3. T. Yamaguchi
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Editors and Affiliations

  1. UK

    R. Fuller (Freelance Consultant in Gut Microecology Reading) (Freelance Consultant in Gut Microecology Reading)

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© 1997 Springer Science+Business Media Dordrecht

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Hosono, A., Kitazawa, H., Yamaguchi, T. (1997). Antimutagenic and Antitumour Activities of Lactic Acid Bacteria. In: Fuller, R. (eds) Probiotics 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5860-2_5

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  • DOI: https://doi.org/10.1007/978-94-011-5860-2_5

  • Publisher Name: Springer, Dordrecht

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