Skip to main content

The Endocrine System of Hagfishes

  • Chapter

Summary

There have been substantial advances in hagfish endocrinology in recent years although restricted to rather specialized areas. Much of the new information has been supported by the availability of new molecular techniques and, as usual for virtually all advances in hagfish biology, has been driven by a continuing appreciation of their unique phylogenetic position and the valuable insights they may contribute to our understanding of evolution. In the pituitary, emphasis has been placed on neurosecretory activity, especially for hypothalamic gonadotrophin-releasing hormone (GnRH) and arginine vasotocin. The most dramatic advances have come in the area of pancreatic hormones where both insulin and insulin-like growth factors (IGFs) have been identified and the full sequence of Myxine insulin confirmed. Distribution is widespread and includes neurones in the brain as well as pancreatic islets. Other endocrine advances are less well documented particularly with respect to biological functions. Of particular note is the identification of substance P and a native natriuretic peptide both as potent vasoregulatory factors.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   149.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baulieu, E.E. and Kelly, P.A. (1990) Hormones: From Molecules to Disease, Chapman & Hall, New York, London, 708 pp.

    Google Scholar 

  • Braun, C.B., Wicht, H. and Northcutt, R.G. (1995) Distribution of gonadotrophin-releasing hormone immunoreactivity in the brain of the Pacific hagfish Eptatretus stoutii (Craniata, Myxinoidea). J. Comp. Neurol., 353, 464–476.

    Article  PubMed  CAS  Google Scholar 

  • Brodal, A. and Fänge, R. (1963) The Biology of Myxine, Universitetsforlaget, Oslo, 588 pp.

    Google Scholar 

  • Chan, S.J., Cao, Q.-P., Nagamatsu, S. and Steiner, D.F. (1993) Insulin and insulin-like growth factor genes in fishes and other primitive chor-dates, in Biochemistry and Molecular Biology of Fishes, Vol. 2 (eds P. Hochachka and T. Mommsen), Elsevier, pp. 407-417.

    Google Scholar 

  • Conlon, J.M. and Falkmer, S. (1989) Neurohormonal peptides in the gut of the Atlantic hagfish (Myxine glutinosa) detected using antisera raised against mammalian regulatory peptides. Gen. Comp. Endocrinol., 76, 292–300.

    Article  PubMed  CAS  Google Scholar 

  • Conlon, J.M., Askensten, U., Falkmer, S. and Thim, L. (1988) Primary structures of somatostatins from the islet organ of the hagfish suggest an anomalous pathway of posttranslational processing of prosomatostatin-1. Endocrinology, 122, 1855–1859.

    Article  PubMed  CAS  Google Scholar 

  • Dimaline, R. (1989) Vasoactive intestinal peptide, in The Comparative Physiology of Regulatory Peptides (ed. S. Holmgren), Chapman & Hall, London, pp. 150–173.

    Chapter  Google Scholar 

  • Dugay, S.J., Chan, S.J., Mommsen, T.P. and Steiner, D.F. (1995) Divergence of insulin-like growth factors I and II in the elasmobranch Squalus acanthias. Febs Letters, 371, 69–72.

    Article  Google Scholar 

  • Emdin, S.O. and Falkmer, S. (1977) Phylogeny of insulin. Acta Paediat-Scand. Suppl., 270, 15–25.

    CAS  Google Scholar 

  • Emdin, S.O. (1982a) Effects of hagfish insulin in the Atlantic hagfish Myxine glutinosa: in vivo metabolism of 14C-glucose and 14C-leucine and studies on starvation and glucose loading. Gen. Comp. Endocrinol., 47, 414–425.

    Article  PubMed  CAS  Google Scholar 

  • Emdin, S.O. (1982b) Insulin release in the Atlantic hagfish Myxine glutinosa, in vitro. Gen. Comp. Endocrinol., 48, 333–341.

    Article  PubMed  CAS  Google Scholar 

  • Emdin, S.O., Steiner, D.F., Chan, S.J. and Falkmer, S. (1985) Hagfish insulin: evolution of insulin, in Evolutionary Biology of Primitive Fishes (eds R.E. Foreman, A. Gorbman, J.M. Dodd and R. Olsson), New York, Plenum Press, 363–378.

    Chapter  Google Scholar 

  • Falkmer, S. (1993) Phylogeny and ontogeny of the neuroendocrine cells of the gastrointestinal tract. Endocr. Metabol. Clin. N. Amer., 22, 731–752.

    CAS  Google Scholar 

  • Falkmer, S. (1995) Origin of parenchymal cells of the endocrine pancreas: some phylogenetic and onto-genetic aspects. Front. Gastrointest. Res., 23, 2–29.

    Google Scholar 

  • Falkmer, S., Cutfield, J.F., Cutfield, S.M., Dodson, G.G., Gliemann, J., Gammeltoft, S., Marques, M., Peterson, J.D., Steiner, D.F., Dundby, F., Emdin, S.O., Havu, N., Östberg, Y. and Windbladh, L. (1975) Comparative endocrinology of insulin and glucagon production. Amer. Zool., 15, Suppl 1, 255–270.

    Google Scholar 

  • Falkmer, S., Ebert, R., Arnold, R. and Creutzfeldt, W. (1980) Some phylogenetic aspects on the enteroinsular axis with particular reference to the appearance of the gastric inhibitory Polypeptide. Front. Horm. Res., 7, 1–6.

    CAS  Google Scholar 

  • Forster, M.E. and Fenwick, J.C. (1994) Stimulation of calcium efflux from the hagfish Eptatretus cirrhatus gill pouch by an extract of corpuscles of Stannius from an eel (Anguilla dieffenbachii)-teleostei. Gen. Comp. Endocrinol., 94, 92–103.

    Article  PubMed  CAS  Google Scholar 

  • Gorbman, A., Dickhoff, W., Vigna, S.R., Clark, N.B. and Ralph, C.L. (1983) Comparative Endocrinology, J. Wiley & Sons, New York, 572 pp.

    Google Scholar 

  • Inui, Y. and Gorbman, A. (1977) Sensitivity of Pacific hagfish, Eptatretus stoutii, to mammalian insulin. Gen. Comp. Endocrinol., 33, 423–427.

    Article  PubMed  CAS  Google Scholar 

  • Jackson, I.M.D. (1980) Distribution and evolutionary significance of the hypophysiotropic hormones of the hypothalamus. Front. Horm. Res., 7, 36–69.

    Google Scholar 

  • Jansson, L. and Falkmer, S. (1997) Islet organ blood flow in a Cyclostome, Myxine glutinosa. Amer. J. Physiol., 00, 000–000. In press.

    Google Scholar 

  • Johnsen, A.H. and Rehfeld, J.F. (1990) Cionin: a disulfotyrosyl hybrid of cholecystokinin and gastrin from the neural ganglion of the proto-chordate dona intestinalis. J. Biol. Chem., 265, 3054–3058.

    PubMed  CAS  Google Scholar 

  • King, J.A. and Millar, R.P. (1980) Comparative aspects of luteinizing hormone-releasing hormone structure and function in vertebrate phylogeny. Endocrinology, 106, 707–717.

    Article  PubMed  CAS  Google Scholar 

  • King, J.A. and Millar, R.P. (1995) Evolutionary aspects of gonadotrophin-releasing hormone and its receptors. Cellular and Molecular Neurobiology, 15, 5–23.

    Article  PubMed  CAS  Google Scholar 

  • Liddle, R.A. (1994) Cholecystokinin, in Gut Peptides: Biochemistry and Physiology (eds J.H. Walsh and G.J. Dockray), Raven Press, New York, pp. 175–216.

    Google Scholar 

  • Nagamatsu, S., Chan, S.J., Falkmer, S. and Steiner, D.F. (1991) Evolution of the insulin gene super-family. Sequence of a preproinsulin-like growth factor cDNA from the Atlantic hagfish. J. Biol. Chem., 266, 2397–2402.

    PubMed  CAS  Google Scholar 

  • Nozaki, M. and Gorbman, A. (1983) Immunocytochemical localization of somato-statin and vasotocin in the brain of the Pacific hagfish Eptatretus stouti. Cell Tissue Res., 229, 541–550.

    Article  PubMed  CAS  Google Scholar 

  • Pernow, B. (1983) Substance P. Pharmacol. Rev., 25, 85–141.

    Google Scholar 

  • Petersen, J.D., Steiner, D.F., Emdin, S.O. and Falkmer, S. (1975) The amino acid sequence of the insulin from a primitive vertebrate, the Atlantic hagfish (Myxine glutinosa). J. Biol. Chem., 250, 5183–5191.

    Google Scholar 

  • Plisetskaya, E.M. (1985) Some aspects of hormonal regulation of metabolism in agnathans, in Evolutionary Biology of Primitive Fishes (eds R.E. Foreman, A. Gorbman, J.M. Dodd and R. Olsson), Plenum Press, New York, pp. 339–361.

    Chapter  Google Scholar 

  • Plisetskaya, E.M. Pollock, H.G., Elliott, W.M., Youson, J.N. and Andrews, P.C. (1988) Isolation and structure of lamprey (Petromyzon marinus) insulin. Gen. Comp. Endocrinol., 69, 46–55.

    Article  PubMed  CAS  Google Scholar 

  • Reinecke, M. (1987) Substance P is a vasoactive hormone in the Atlantic hagfish Myxine glutinosa (Cyclostomata). Gen. Comp. Endocrinol., 66, 291–296.

    Article  PubMed  CAS  Google Scholar 

  • Reinecke, M. (1989) Atrial natriuretic peptides-localization, structure and phylogeny, in S. Holmgren (ed.), The Comparative Physiology of Regulatory Peptides, Chapman & Hall, London and New York, pp. 5–33.

    Google Scholar 

  • Reinecke, M., Betzler, D. and Forsmann, W.-G. (1987) Immunocytochemistry of cardiac Polypeptide hormones (Cardiodilatin/atrial natriuretic Polypeptide) in brain and hearts of Myxine glutinosa (Cyclostomata). Histochemistry, 86, 233–239.

    Article  PubMed  CAS  Google Scholar 

  • Reinecke, M., Betzler, M., Aoki, A. and Forsmann, W.-G. (1993) Atrial natriuretic peptides (ANP) in fish heart, in Fish Ecotoxicology and Ecophysiology (eds T. Braunbeck, W. Hanke and H. Segner), VCH Verlagsgesellschaft mbh, D-6940 Weinheurn, Germany, pp. 285–404.

    Google Scholar 

  • Reinecke, M., Drakenberg, K., Falkmer, S. and Sara, V.R. (1991) Presence of IGF-1-like peptides in the neuroendocrine system of the Atlantic hagfish, Myxine glutinosa (Cyclostomata): evidence derived by chromatography radioim-munoassay and immunocytochemistry. Histochemistry, 96, 191–196.

    Article  PubMed  CAS  Google Scholar 

  • Reinecke, M., Schluter, P., Yanaihara, N. and Forsmann, W.-G. (1981) VIP immunoreactivity in enteric nerves and endocrine cells of the vertebrate gut. Peptides, 2, Suppl. 2, 149–156.

    Article  PubMed  CAS  Google Scholar 

  • Shibata, Y. and Yamamoto, T. (1976) Fine structure and cytochemistry of specific granules in the lamprey atrium. Cell Tissue Res., 172, 487–501.

    Article  PubMed  CAS  Google Scholar 

  • Sower, S.A., Nozaki, M., Knox, C.J. and Gorbman, A. (1995) The occurrence and distribution of GnRH in the brain of Atlantic hagfish, an Agnathan, determined by chromatography and immunocytochemistry. Gen. Comp. Endocnnol., 97, 300–307.

    Article  CAS  Google Scholar 

  • Suzuki, M., Kubokawa, M., Nagasawa, K. and Vrano, A. (1995) Sequence analysis of vasotocin cDNAs of the lamprey, Lampetra japonica and the hagfish Eptatretus burgeri — Evolution of eyclostome vasotocin precursors. J. Mol. Endocnnol., 14, 67–77.

    Article  CAS  Google Scholar 

  • Thorndyke, M.C. and Dockray, G.J. (1986) Identification and localization of material with gastrin-like immunoreactivity in the neural ganglion of a protochordate Ciona intestinalis. Regulatory Peptides, 16, 269–279.

    Article  PubMed  CAS  Google Scholar 

  • Thorndyke, M.C. and Falkmer, S. (1985) Evolution of gastro-entero-pancreatic endocrine systems in lower vertebrates, in Evolutionary Biology of Primitive Fishes (eds R.E. Foreman, A. Gorbman, J.M. Dodd and R. Olsson), Plenum Press, New York, pp. 379–400.

    Chapter  Google Scholar 

  • Thorndyke, M.C., Purvis, D. and Plisetskaya, E.M. (1989) Insulin-like immunoreactivity in the brain of two hagfishes, Eptatretus stouti and Myxine glutinosa. Gen. Comp. Endocrinol., 76, 371–381.

    Article  PubMed  CAS  Google Scholar 

  • Toop, D., Donald, J.A. and Evans, D.H. (1995) Localization and characteristics of natriuretic peptide receptors in the gills of the Atlantic hagfish Myxine glutinosa (Agnatha). J. Exp. Biol., 195, 117–126.

    Google Scholar 

  • Vigna, S.R. (1979) Distinction between cholecys-tokinin-like and gastrin-like biological activities extracted from gastrointestinal tissues of some lower vertebrates. Gen. Comp. Endocrinol., 39, 512–520.

    Article  PubMed  CAS  Google Scholar 

  • Vigna, S.R. and Gorbman, A. (1979) Stimulation of intestinal lipase secretion by porcine cholecys-tokinin in the hagfish, Eptatretus stoutii. Gen. Comp. Endocrinol., 38, 356–359.

    Article  PubMed  CAS  Google Scholar 

  • Zandeberger, M.A., Kah, O., Bogerd, J., Pente, J. and Goos, H.J.T. (1995) Expression and distribution of two gonadotrophin-releasing hormones in the catfish brain. Neuroendocrinology, 62, 571–577.

    Article  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Thorndyke, M.C., Falkmer, S. (1998). The Endocrine System of Hagfishes. In: The Biology of Hagfishes. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5834-3_26

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-5834-3_26

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6465-1

  • Online ISBN: 978-94-011-5834-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics