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Evidence and Mechanistic Approach of the Protective Effects of Heavy Metal High Dilutions in Rodents and Renal Cell Cultures

Protective effect of metal high dilutions

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Signals and Images

Abstract

Chronic exposure to heavy metals (e.g cadmium or lead), which are major environmental toxicants, can be associated with a variety of pathologies such as renal, hepatic or nervous damages (Mery and Fillastre, 1983; Humes and Weinberg, 1986). For decades, several authors have attempted to reduce in vivo metal toxicity using chelating agents or other metals as competing agents. Another method successfully applied consisted of pre- or post-treatment using either low concentrations (Terhar et al.., 1965; Ito and Sawauchi, 1966; Yoshikawa, 1973) or high dilutions (Fisher et al.., 1987; Cazin et al.., 1987; Herkovitz and Perez-Coll, 1991) of the same toxic inducing agent. Critical rewiews on the effectiveness of serially dilute agitated compounds in experimental toxicology have been recently published (Linde et al., 1994; Cambar et al., 1994).

Communications presented at the 7th GIRI Meeting, November 1993, Montpellier, France, and at the 8th GIRI Meeting, December 1994, Jerusalem, israel.

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Delbancut, A., Barouillet, M.P., Cambar, J. (1997). Evidence and Mechanistic Approach of the Protective Effects of Heavy Metal High Dilutions in Rodents and Renal Cell Cultures. In: Bastide, M. (eds) Signals and Images. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5804-6_6

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  • DOI: https://doi.org/10.1007/978-94-011-5804-6_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6451-4

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