Abstract
Eight patients, two male and six female, aged between 24 and 48 years, with Graves’ disease and severe ophthalmopathy were included in the study. A standardized A-scan echography was performed to evaluate the reflectivity of the extraocular muscles (EOMs); a planar scintigraphy (PS) and/or a single photon emission computed tomography (SPECT) were also performed at various times after endovenous injection of 111 MBq In-111 OCT, a somatostatin analogue.
Reflectivity of EOMs was demonstrated by A-scan echography in four patients with active Graves’ ophthalmology (GO) (group 1) and in four patients with non active GO (group 2). Scintigraphic results were in accordance with echographic findings. The reflectivity was higher in the former four patients than in the latter four. In patients of group 1, there was a significant labelled OCT accumulation in orbital tissue, while an orbital accumulation was not observed in group 2.
High reflectivity of EOMs as demonstrated by standardized A-scan echography and accumulation of In-111 OCT in orbital tissue as shown by scintigraphy are parameters of disease activity in GO. Standardized A-scan echography and In-111 OCT scan are useful, easy to perform and non invasive methods. They reveal the presence of flogosis and/or fibrosis in orbital tissue, and define the severity of the disorder in patients with ophthalmology.
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Bizzarro, A. et al. (1997). A new approach to the study of Graves’ ophthalmopathy: standardized A-scan echography and octreotide scintigraphy as possible parameters for disease activity. In: Cennamo, G., Rosa, N. (eds) Ultrasonography in Ophthalmology XV. Documenta Ophthalmologica Proceedings Series, vol 61. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5802-2_43
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DOI: https://doi.org/10.1007/978-94-011-5802-2_43
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