Abstract
The reactions of 2-acetylpyridine thiosemicarbazone (HAc4DH), 4N-phenyl-2- acetylpyridine thiosemicarbazone (HAc4Ph), and 4N-dimethyl-2-acetyl pyridine thiosemicarbazone (HAc4DM) with palladium(II) were studied. The ligands and the palladium(II) complexes have been characterized by spectroscopic, structural and electrochemical techniques. Their effect on DNA synthesis of P388 and LI210 cell cultures is also reported.
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The antitumoural screening was performed by Dr. A. Papageorgiou, Laboratory of Experimental Chemotherapy, Thiagenio Anticancer Institute, Thessaloniki. Incorporation of (Methyl-3H) Thymidine: L1210 leukemia cells were grown in RPMI-1640 medium; P388 cells were grown in Dulbeccos medium. All media were supplemented with 10% calf serum, streptomycin penicillin and 42 mM HEPES. DNA synthesis was determined after 30 min incubation of the cells with the (methyl-3H) Thymidine precursor of DNA. The cells suspension was placed on whatman N° 41 filters and the wet filters were soaked in 5% cold TCA, twice in 96%alcohol, once in mixture of ether:ethanol (1:1) and once in ether. After drying the filters were placed in scintillation fluid and the radioactivity was determined.
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Kovala-Demertzi, D., Domopoulou, A., Demertzis, M.A. (1997). Synthesis, Spectroscopy and Structures of Complexes of PD(II) with 4N-Substituted Derivatives of 2-Acetylpyridine Thiosemicarbazone. In: Hadjiliadis, N.D. (eds) Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment. NATO ASI Series, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5780-3_29
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DOI: https://doi.org/10.1007/978-94-011-5780-3_29
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