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Mechanistic Aspects of Pt Antitumor Chemistry

Structure-activity relationships and the relative importance of platinum binding to nucleic acids and proteins

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Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment

Part of the book series: NATO ASI Series ((ASEN2,volume 26))

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Abstract

Even though simple Platinum compounds, like cis-PtCl2(NH3)2 (abbreviated in literature as CDDP, cis-Pt, cisplatin), have been known for over 150 years, the biological activity of the parent compound has been reported only in the mid-sixties as the result of a serendipitous discovery by Rosenberg [1].

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Authors and Affiliations

  1. Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O.Box 9502, 2300 RA, Leiden, The Netherlands

    Jan Reedijk

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  1. Jan Reedijk
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Editors and Affiliations

  1. Laboratory of Inorganic and General Chemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

    Nick D. Hadjiliadis

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Reedijk, J. (1997). Mechanistic Aspects of Pt Antitumor Chemistry. In: Hadjiliadis, N.D. (eds) Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment. NATO ASI Series, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5780-3_25

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  • DOI: https://doi.org/10.1007/978-94-011-5780-3_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6440-8

  • Online ISBN: 978-94-011-5780-3

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