Skip to main content
SpringerLink
Log in

The Relationship of 252Cf and 226Ra Radiation Doses to the Reoxygenation and Regression of Cervix Uteri Tumors

Part I: Clinical experimental study

  • Chapter
Californium-252 Isotope for 21st Century Radiotherapy

Part of the book series: NATO ASI Series ((ASHT,volume 29))

  • 235 Accesses

Abstract

In the period of March, 1986 to March, 1990, the authors studied the changes in oxygenation and regression of cervix uteri tumors for their dependence on the doses of 252Cf applied in the first week of therapy. Ninety-four patients were divided into four groups: a group treated by conventional gamma 226Ra radiation, those treated by 252Cf to 16 Gy-eq and 41 Gy-eq at point A supplement by gamma 226Ra, and a group treated only by 252Cf to 56 Gy-eq. The intracavitary dose applied in all patients was 6 Gy-eq using an RBE of neutron component for 252Cf as 6. A 20 MeV x-ray beam was used for external irradiation to a dose of 49 Gy. The pO2 changes within the tumor were followed at one week intervals up to the sixth week of therapy by means of a polarographic method. The volume changes of the cervix tumor were studied using a CT scan.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Awwad, H.K., Naggar, M., Mocktar, N., Barsoun, M. (1986) Intrecapillar distance measurement as an indicator of hypoxia in carcinoma of the cervix uteri. Int. J. Radiat. Biol. Oncol. Phys., 12, 1329–1333.

    Article  CAS  Google Scholar 

  2. Blaker, W.D., (1987) Computer programm for the parametric and nonparametric comparison of several groups to a control. Comput. Biol. Med., 17,47–44.

    Article  Google Scholar 

  3. Bedford, J.S., Hall, E.G.(1963) Survival of He-la cells cultured in vitro and exposed to protracted gamma radiation. Int. J. Radiat. Biol. Oncol. Phys., 7:377–380

    CAS  Google Scholar 

  4. Barzan, P.J., Butler, H.E., Newlson, A.D., Li Puma, J.P., Kopiwoda, S.Y., Reasnick, M.L., Cohen, A.M., Haaga, J.R. (1986) Magnetic resonance imaging of the prostate, Amer. J. Roentgenol., 146,543–548.

    Google Scholar 

  5. Orton C. Brachytherapy HDR and LDR. (1989) Proceedings Remote Afterloading: State of The Art, 121–137.

    Google Scholar 

  6. Clement, J.J. Tahaka, N., Song, Ch.W. (1978) Tumor reoxigenation and postradiation vascular changes. Radiology, 127, 799–803.

    PubMed  CAS  Google Scholar 

  7. Charman, J.D. (1991) Measurement of tumor hypoxia by invasive and noninvasive procedures: a review of clinical results. Radiother.Oncol suppl. 20, 13–19.

    Article  Google Scholar 

  8. Dische, S. (1985) Chemical sensitizers for hypoxic cells. A decade of experience in clinical radiotherapy. Radiotherapy Oncol. 7,97–115.

    Article  Google Scholar 

  9. Drew, R.M., Fairchild, R.G., Atkins, H.L. (1972) The oxygen enhancement rations measured with He. La cells and protected irradiation from 252Cf and 137Cs. Radiology, 104:404–409.

    Google Scholar 

  10. Djordijevic, B., Anderson, L.L., Song Hie-Kim (1973) Oxygen enhancement rations in He-La cells irradiated with 252Cf and radium sources.

    Google Scholar 

  11. Denekamp, J. (19 ),Endothelial cell proliferation in experimental tumors. Brit.J. Cancer 46, 711–720.

    Article  Google Scholar 

  12. Egava, J., Ishicka, K., Ogata, T.,(1979) Vascular structure of experimental tumors, acta Radiol. Oncol., 18,367–375.

    Article  Google Scholar 

  13. Ellis, F., (1969) Dose, Time and fractionation: a clinical hypothesis, Clin. Radiol. 20, 1–7.

    Article  PubMed  CAS  Google Scholar 

  14. Feola, J.M., Nava, C.A., Maruyama, Y. (1982) Biological effects of 252Cf neutrons at low dose rate. Int. J. Radiat. Biol., 41:33–46.

    Article  CAS  Google Scholar 

  15. Fujino, A., Scardino, T.P., (1986) Transrectalultrasonography for prostatic cancer II The response of prostate to definitive radiotherapy. Cancer., 57,935–940.

    Article  PubMed  CAS  Google Scholar 

  16. Gragg, R.L., Humphrey, P.M., Thames, H.D. Jr., Meyn, R.E. (1978) The response of Chinese hamster ovary cells to fast neutroradiotherapy beams. III Variation in relative biological effectiveness with position in the cell cycle. Radiat. Res. 76,283–289.

    Article  PubMed  CAS  Google Scholar 

  17. Henk, J.M., (1986) Late results of hyperbaric oxygen and radiotherapy in head and neck cancer: a rationale for hypoxic cell sensitisers?, Int. J. Radiat. Oncol. Biol. Phys., 12, 1339–1341.

    Article  PubMed  CAS  Google Scholar 

  18. Hall, E.L., Rossi, H.H., Rozin, L. (1971) Low dose rate irradiation of mammalian cells with radium and californium-252. Radiology, 102, 445–451.

    Google Scholar 

  19. Howes, A.E., Page, A., Fowlwr, J.F. (1972) The effect of single and fractionated doses of x rays on effective proportion of hypoxic cells in C3H mouse mammary tumours (1972) Brit. J. Radiol., 45, 250–256.

    Article  PubMed  CAS  Google Scholar 

  20. Hobson, B., Denekamp, J., (1984) Endothelial proliferation in tumors and normal tissues. Continous labeling studies. Brit. J. Cancer, 49,405–413.

    Article  PubMed  CAS  Google Scholar 

  21. Koch, C.J., Kruuv, J. Frey, H.E. (1973) The effect of hypoxia on the generation time of mammalian cells. Rad. Res. 53, 43–48.

    Article  CAS  Google Scholar 

  22. Kawamula, F., Fujiwara, K. (1973) Effects of radiation on the fine vasculature of normal and malignant tissues. Fraction size in radiology and radiotherapy, Igaku Shoin, Tokio.

    Google Scholar 

  23. Kallman, R.F. (1988) The phenomenon of reoxigenation and its implication for fractionated radiotherapy. Radiology, 105,135–142.

    Google Scholar 

  24. Kallman, R.F. (1988) Reoxygenation and repopulation in irradiated tumours. Front. Radiat. Ther. Onc. Kargel, Basel, 22, 30–49.

    CAS  Google Scholar 

  25. Kallman, R.F., Dorie, M.J. (1986) Tumor oxygenation during radiation therapy: their importance in predicting tumor response. Int. J. Radiat. Oncol. Biol. Phys., 12, 685–691.

    Article  Google Scholar 

  26. Kamprad, F., Arnold, P., Jahns, J., Neumeister, K., Gaunitz, U., Melhorn, G., Kleische, F., Koch, F. (1979) Der Schutzeffekt der Gashypoxie bei Oberflechenbestrahlung der hundehaut. Raport SAAS Berlin, 246, 33–37.

    Google Scholar 

  27. Maruyama, Y., Beach, J.L., Feola, J. (1980) Scheduling of hypoxic-tumor therapy using neutron brachytherapy. Radiology, 137:775–781.

    PubMed  CAS  Google Scholar 

  28. Maruyama, Y., Feola, J., Beach, J.L. (1983) A tumor/normal tissue advantage for low dose rate neutron brachytherapy. Int. J. Radiat. Oncol. Biol. Phys. 9, 1715–1721.

    Article  PubMed  CAS  Google Scholar 

  29. Mamyama, Y., Yoneda, J., Krolikiewicz, H., Mediondo, O., Beach, J.L., Coffey, C.W., Thompson, D., Wilson, L.C., Feola, J., Van Nagell, J.R., Donaldson, E.S., Powell, D. (1980) A clinical trial for advanced cervico-vaginal pelvis carcinomas using californium-252 neutron therapy: report of early responses. Int. J. Radiat. Oncol. Biol. Phys. 6, 1629–1637.

    Article  Google Scholar 

  30. Maruyama, Y., Beach, J.L., Feola, J., (1980) Scheduling of hypoxic tumortherapy using neutron brachytherapy. Radiology, 775–781.

    Google Scholar 

  31. Mueller-Klieser, W., Schienger, K.H., Walenta, S., Gross, M., Karbach, U., Hoeckel, M., Vaupel, P., (1991) Pathophysiological approaches to identifying tumor hypoxia in patients. Radiother. Oncol. Suppl. 20, 21–28.

    Article  Google Scholar 

  32. Moulder, J.E., Rockwell, S. (1987) Hypoxic fractions of solid tumors: experimental techniques. Cancer and Methastasis Reviews, 5,313–341.

    Article  CAS  Google Scholar 

  33. Pilepich, M.V., Prasad, S.C., Parez, C.A., (1982) Computed tomography in definitive radiotherapy of prostatic carcinoma, part 2: Definition of target volume.Int. J. Radiat. Oncol. Biol. Phys., 8, 235–240.

    Article  PubMed  CAS  Google Scholar 

  34. Pappova, N., Siracka, E., Vacek, A., Durkovsky, J. (1982) Oxygen tension and prediction of radiation response. Polygraphyc study in human breast cancer. Neoplasma, 29, 669–674.

    PubMed  CAS  Google Scholar 

  35. Steel, G.G., Peacock, J.H. (1989) Why are some human tumors more radiosensitive then others. Radiother. Oncol. 15, 63–72.

    Article  PubMed  CAS  Google Scholar 

  36. Tacev, T., Prokes, B., Strand, V., Rasovska, O., Krystof, V., Nikodemova, D. (1989) Effect of small doses of Cf-252 on the tumor regression in cervix uteri during combined radiotherapy. Strahlenther. Oncol. 165, 837–843.

    CAS  Google Scholar 

  37. Tacev, T., Krystof, V., Spurny, V., Caha, A., Ott, O., Kucera, F., Ptackova, B., Kabela, M. (1980) Combined treatment of carcinoma of the cervix uteri by radium and x-rays extended field of betatron 42 MeV, Ces. Radiol. 34, 174–181 (in Czech).

    CAS  Google Scholar 

  38. Tacev, T., Krystof, V., Dupak, J., Kastak, B., Rasovska, O., Strand, V. (1989) Applicators of manual afterloading for intracavitary brachytherapy. Cs. Radiol. 43, 187–194 (in Czech).

    Google Scholar 

  39. Tacev, T., Michalek, J., Polach, J. (1992) A contribution to the comparison of the efficacy of radiotherapeutic procedures in cervical carcinoma. Acta Oncol., 6, 663–668.

    Article  Google Scholar 

  40. Thompson, S. G., Street, K., Chiroseo, A., Seabork, G. T. (1950) The new element californium (atomic number 98). Phys. Rev., 80, 790–796.

    Article  CAS  Google Scholar 

  41. Thomlinson, R. H., Gray, L.H. (1955) The histological structure of some human lung cancers and the possible implications for radiotherapy. Brit. J. Cancer, 9, 539–549.

    Article  PubMed  CAS  Google Scholar 

  42. Thames, H. D., Withers, H. R., Peters, L. J., Fletcher, G. M. (1982) Changes in early and late radiation responses with altered dose fractionation: implications for dose dose-survival relationships. Int. J. Rad. Oncol. Biol. Phys., 8, 219–226.

    Article  Google Scholar 

  43. Tannock, I. (1976) Oxygen distribution in tumorus: influence on cell proliferation and implication for tumour therapy. Advances in Exp. Med and Biol., 75, 597–603.

    CAS  Google Scholar 

  44. Vacek, A., Kovalenko, E. A., Sebela, A., Kovar, M., Novak, A. (1981) Tension of oxygen tissues and possibilities of determination by the “oxymeter” device. Acta Facult. Med. Univ. Brunensis, 92, 557–560.

    Google Scholar 

  45. Vacek, A., Bartinickova, A., Rotkova, D., Zhukova, V. A., Palyga, G. F. (1986) Increased protective effect of hypoxia against radiation following activation of haemopoiesis with dextrane sulphate. Acta Radiol. Oncol., 285–289.

    Google Scholar 

  46. Vilmann, P., Hancke. S., Strange-Vongsen, H.H., Nielsen, K., Sorensen, S. M. (1987) Therehability of transabdominal ultrasound scanning in the determination of prostatic volume. Scand. J. Urol. Nephro., 21, 5–7.

    Article  CAS  Google Scholar 

  47. Van Putten, L. M. (1977) Reoxygenation of hypoxic tumour cells. Strahlenther., 153, 380–383.

    Google Scholar 

  48. Winters, H.R., Mason, K., Reid, B.O., Dubravsky, N., Barkley, H.Z., Jr., Brown, B.W., Smathers, J.B. (974) Response of mouse intestine to neutrons and gamma rays in relation to dose fraction and division cycle. Cancer, 34:39–46.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiotherapy, Masaryk Memorial Cancer Institute, Brno, Czech Republic

    T. Tačev, O. Rašovská, V. Strnad & V. Krystof

  2. Department of Gynaecology, Masaryk Memorial Cancer Institute, Brno, Czech Republic

    B. Ptáčková

  3. constitute of Biophysics, Academy of Sciences Czech Republic, Bono, Czech Republic

    A. Vacek

  4. II. Clinic of Radiology, Faculty of Medicine, Mesaraic University, Bono-Bohunice, Czech Republic

    B. Prokes

Authors
  1. T. Tačev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Vacek
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Prokes
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. O. Rašovská
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. Ptáčková
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. Strnad
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. V. Krystof
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Wayne State University, Detroit, Michigan, USA

    Jacek G. Wierzbicki (Associate Professor) (Associate Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Tačev, T. et al. (1997). The Relationship of 252Cf and 226Ra Radiation Doses to the Reoxygenation and Regression of Cervix Uteri Tumors. In: Wierzbicki, J.G. (eds) Californium-252 Isotope for 21st Century Radiotherapy. NATO ASI Series, vol 29. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5766-7_4

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-5766-7_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6433-0

  • Online ISBN: 978-94-011-5766-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation