Abstract
Growth of most Rhizobium strains is inhibited by mimosine, a toxin found in large quantities in the seeds, foliage and roots of plants of the genera Leucaena and Mimosa. Some Leucaena-nouuXdXmg strains of Rhizobium can degrade mimosine (Mid+) and are less inhibited by mimosine in the growth medium than the mimosine-non-degrading (Mid-) strains. Ten Mid+ strains were identified that did not degrade 3-hydroxy-4-pyridone (HP), a toxic intermediate of mimosine degradation. However, mimosine was completely degraded by these strains and HP was not accumulated in the cells when these strains were grown in a medium containing mimosine as the sole source of carbon and nitrogen. The mimosine-degrading ability of rhizobia is not essential for nodulation of Leucaena species, but it provides growth advantages to Rhizobium strains that can utilize mimosine, and it suppresses the growth of other strains that are sensitive to this toxin.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Allison M J, Mayberry W R, Mcweeney C S and Stahl D A 1992 Synergistes jonesii, gen. nov., sp. nov: a rumen bacterium that degrades toxic pyridinediols. Syst. Appl. Microbiol. 15, 522–529.
Boehme S A and Lenardo M J 1993 Ligand-induced apoptosis of mature T lymphocytes (propriocidal regulation) occurs at distinct stages of the cell cycle. Leukemia 7, 45–49.
Brewbaker J L and Hylin J W 1965 Variations in mimosine content among Leucaena species and related mimosaceae. Crop. Sci. 5, 348–349.
Crounse R G, Maxwell R D and Blank H 1962 Inhibition of growth of hair by mimosine. Nature 194, 694–695.
Dai Y, Gold B, Vishwanatha J K and Rhode S L 1994 Mimosine inhibits viral synthesis through ribonucleotide reductase. Virology 205, 210–216.
Feldman S T and Schonthal A 1994 Negative regulation of Histone HI kinase expression by mimosine, a plant amino acid. Cancer Res. 54, 494–498.
George M L C, Young J P W and Borthakur D 1994 Genetic characterization of Rhizobiwn sp. strain TALI 145 that nodulates tree legumes. Can. J. Microbiol. 40, 208–215.
Hegarty M P, Schinckel P G and Court R D 1964 Reaction of sheep to the consumption of Leucaena glauca Benth. and to its toxic principle mimosine. Aust. J. Agric. Res. 15, 153–167.
Hoffman B D, Hanauske-Abel H M, Flint A and Lalande M 1991 A new class of reversible inhibitors. Cytometry 12, 26–32.
Khanna K K and Lavin M F 1993 Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene 8, 3307–3312.
Levenson V and Hamlin J L 1993 A general protocol for evaluating the specific effects of DNA replication inhibitors. Nucleic Acids Res. 21, 3997–004.
Lowry J B, Maryanto and Tangendjaja B 1983 Optimising autolysis of mimosine to 3-hydroxy-4(lH)pyridone in green tissue of Leucaena leucocephala. J. Sci. Food Agric. 34, 529–533.
Mosca P J, Dijkwel P A and Hamlin J A 1992 The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells. Mol. Cell Biol. 12, 4375–1383.
Parveen N and Borthakur D 1994 Construction of a single-transposon-insertion mutant in Rhiz.obium sp. strain TALI 145 from a double-insertion mutant. Lett. Appl. Microbiol. 19, 142–145.
Perennes C, Qin L X, Glab N and Bergounioux C 1993 Petunia p34cdc2 protein kinase activity in G2/m cells obtained with a reversible cell cycle inhibitor, mimosine. FEBS Lett. 333, 141–145.
Pooyan S, George M L C and Borthakur D 1994 Isolation and characterization of a gene for nodule development linked to the ndvA and ndvB genes in Rhizobium sp. strain TALI 145. Symbiosis 17, 201–215.
Reis P J, Tunks D A and Hegarty M P 1975 Fate of mimosine administered orally to sheep and its effectiveness as a defleecing agent. Aust. J. Biol. Sci. 28, 495–501.
Soedarjo M, Hemscheidt T K and Borthakur D 1994 Mimosine, a toxin present in leguminous trees (Leucaena spp.) induces a mimosine-degrading enzyme activity in some strains. Appl. Environ. Microbiol. 12, 4268–4272.
Soedarjo M and Borthakur D 1996 Simple procedures to remove mimosine from young leaves, seeds and pods of Leucaena leucocephala used as food. Int. J. Food Sci. Technol. 36, 103–109.
Tangendjaja B and Wills R B H 1980 Analysis of mimosine and 3-hydroxy-4-(lH)-pyridone by high-performance liquid chro-matography. J. Chromatogr. 202, 317–318.
Telfer J F and Green C D 1993 Placental alkaline phosphatase activity is inversely related to cell growth rate in HeLaS3 cervical cancer cells. FEBS Lett. 329, 238–2344.
Thompson J F, Morris C J and Smith I K 1969 New naturally occurring amino acids. Annu. Rev. Biochem. 38, 137–158.
Watters D J, Beamish H J, Marshall K A, Gardiner R A, Seymour G J and Lavin M F 1994 Accumulation of HL60 leukemia cells in G2/M and inhibition of cytokinesis caused by two marine compounds, bistratene A and cyclohexazoline. Cancer Chemo. Pharmacol. 33, 399–409.
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Soedarjo, M., Borthakur, D. (1996). Mimosine produced by the tree-legume Leucaena provides growth advantages to some Rhizobium strains that utilize it as a source of carbon and nitrogen. In: Elkan, G.H., Upchurch, R.G. (eds) Current Issues in Symbiotic Nitrogen Fixation. Developments in Plant and Soil Sciences, vol 72. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5700-1_12
Download citation
DOI: https://doi.org/10.1007/978-94-011-5700-1_12
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6404-0
Online ISBN: 978-94-011-5700-1
eBook Packages: Springer Book Archive