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Estrogen Replacement Therapy and Cognitive Functions in Elderly Women

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Book cover Women’s Health and Menopause

Part of the book series: Medical Science Symposia Series ((MSSS,volume 11))

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Abstract

While the relation of most risk factors for Alzheimer’s disease (AD) remains to be confirmed, the risk of AD increases strongly with age, suggesting that genetic and environmental factors which influence aging of the brain may play an important part. Family history of dementia, increasing age, and the presence of Down’s syndrome are proven risk factors for Alzheimer’s disease, and in some families, specific chromosomal mutations have been identified. However, the role of these genes in late-onset AD, which concerns the vast majority of patients in the population, is limited; ApoE gene on chromosome 19 seems to play a part and the possession of apoE4 increases the risk. Other risk factors implicated in the disease include head injury, female sex, hypothyroidism, and depression, with education, smoking, and use of nonsteroidal antiinflammatory agents being protective [1,2].

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References

  1. Van Duijn CM. Epidemiology of dementias: Recent developments and new approaches. J Neurol Neurosurg Psychiatry 1996;60:478–88.

    Article  PubMed  Google Scholar 

  2. Burns A, Murphy D. Protection against Alzheimer’s disease? Lancet 1996;348:420–21.

    Article  PubMed  CAS  Google Scholar 

  3. Simpkins JW, Sing M, Bishop J. The potential role for oestrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer’s disease. Neurobiol Aging 1994;15(Suppl 2);S195–S197.

    Article  PubMed  Google Scholar 

  4. Birge SJ. Is there a role for oestrogen replacement therapy in the prevention and treatment of dementia? J Am Geriatr Soc 1996;44:865–70.

    PubMed  CAS  Google Scholar 

  5. Toran-Allerand CD, Miranda RC, Bentham WDL, et al. Oestrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain. Proc Natl Acad Sci 1992;89:4668–72.

    Article  PubMed  CAS  Google Scholar 

  6. Sullivan JM. Oestrogen Replacement. Circulation 1996;94:2699–2702.

    Article  PubMed  CAS  Google Scholar 

  7. Lobo RA. Benefits and risks estrogen replacement therapy. Am J Obstet Gynecol 1995;173:982–90.

    Article  PubMed  CAS  Google Scholar 

  8. Simpkins JW, Singh M, Bishop J. The potential role for estrogen replacement therapy in the treatment of cognitive decline and neurodegeneration associated with Alzheimer’s disease. Neurobiol Aging 1994;15(Suppl 2):S195–S197.

    Article  PubMed  Google Scholar 

  9. Jaffe AB, Toran-Allerand CD, Greengard P, Gandy SE. Estrogen regulates metabolism of Alzheimer amyloid Beta precursor protein. J Biol Chem 1994;269:13065–68.

    PubMed  CAS  Google Scholar 

  10. Honjo H, Tanaka K, Kashiwagi T, et al. Senile dementia-Alzheimer’s type and estrogen. Hor Metab Res 1995;27:204–7.

    Article  CAS  Google Scholar 

  11. Behl C, Widman M, Trapp T, Holsboer F. 17-Beta-Estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem Biophys Res Com 1995;216:473–82.

    Article  PubMed  CAS  Google Scholar 

  12. Gilligan DM, Quyyumi AA, Cannon RO. Effects of physiological levels of estrogens on coronary vasomotor function in postmenopausal women. Circulation 1994;89:2545–51.

    Article  PubMed  CAS  Google Scholar 

  13. Van Buren G, Yang D, Clark KE. Estrogen-induced uterine vasodilatation is antagonised by L-nitroarginine methylester, an inhibitor of nitric oxide synthesis. Am J Obstet Gynecol 1992;16:828–33.

    Google Scholar 

  14. Second symposium on ageing and ageing disorders, Stockholm 1993. Dementia 1994;5:129–213.

    Google Scholar 

  15. O’Brien MD. How does cerebrovascular disease cause dementia? Dementia 1994;5:133–36.

    PubMed  Google Scholar 

  16. Falkebom M, Persson I, Terent A. Hormone replacement therapy and the risk of stroke. Arch Intern Med 1993;153:1201–9.

    Article  Google Scholar 

  17. Ganger KF, Vyas S, Whitehead M, at al. Pulsatility index in internal carotid artery in relation to transdermal oestradiol and time since menopause. Lancet 1991;338:839–42.

    Article  Google Scholar 

  18. Schmidt R, Fazekas F, Reinhart B, et al. Estrogen replacement therapy in older women: A neuropsychological and brain MRI study. J Am Geriatr Soc 1996;44:1307–13.

    PubMed  CAS  Google Scholar 

  19. Barrett-Connor E, Kritz-Silverstein D. Estrogen replacement therapy and cognitive function in older women. JAMA 1993;269:2637–41.

    Article  PubMed  CAS  Google Scholar 

  20. Sherwin BB. Estrogenic effects on memory in women. Ann NY Acad Sci 1994;743:213–31.

    Article  PubMed  CAS  Google Scholar 

  21. Rocca WA, Hofman A, Brayne C, et al. Frequency and distribution of Alzheimer’s disease in Europe: A collaborative study of 1980–1990 prevalence findings. Ann Neurol 1991;30:381–90.

    Article  PubMed  CAS  Google Scholar 

  22. Berlinger WG, Potter JF. Low body mass index in demented outpatients. J Am Geriatr Soc 1991;39:973–78.

    PubMed  CAS  Google Scholar 

  23. Rudman D, Shetty KR, Mattson DE. Plasma dehydroepiandrosterone-sulphate in nursing home men. J Am Geriatr Soc 1990;38:421–27.

    PubMed  CAS  Google Scholar 

  24. Paganini-Hill A, Henderson VW. Estrogen deficiency and risk of Alzheimer’s disease in women. Am J Epidemiol 1994;140:262–67.

    Google Scholar 

  25. Henderson VW, Paganini-Hill A, Emanuel CK, Dunn ME, Buckwalter JG. Estrogen replacement therapy in older women: Comparison between Alzheimer’s disease cases and nondemented control subjects. Arch Neurol 1994;51:896–900.

    Article  PubMed  CAS  Google Scholar 

  26. Tang M, Jacobs D, Stern Y, et al. Effects of oestrogen during menopause on risk and age at onset of Alzheimer’s disease. Lancet 1996;348:420–21.

    Article  Google Scholar 

  27. Barrett-Connor E, Kritz-Silverstein D. Estrogen replacement therapy and cognitive function in older women. JAMA 1993;269:2637–41.

    Article  PubMed  CAS  Google Scholar 

  28. Brenner DE, Kukull WA, Stregachis A, et al. Postmenopausal estrogen replacement therapy and the risk of Alzheimer’s disease: A population-based case-control study. Am J Epidemiol 1994;140:262–67.

    PubMed  CAS  Google Scholar 

  29. Schneider LS, Farlow MR, Henderson VW, Pogoda JM. Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer’s disease. Neurology 1996;46:1580–84.

    Article  PubMed  CAS  Google Scholar 

  30. Kuller LH. Hormone replacement therapy and its potential relationship to dementia. J Am Geriatr Soc 1996;44:878–80.

    PubMed  CAS  Google Scholar 

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Authors
  1. Orazio Zanetti
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  2. Angelo Bianchetti
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  3. Stefano Govoni
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  4. Marco Trabucchi
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Editor information

Editors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti

  2. Department of Obstetrics and Gynecology, University of Milan, Milan, Italy

    P. G. Crosignani

  3. Department of Obstetrics and Gynaecology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands

    P. Kenemans

  4. Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden

    G. Samsioe

  5. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    M. R. Soma

  6. Giovanni Lorenzini Medical Foundation, Houston, Texas, USA

    A. S. Jackson (Managing Editor) (Managing Editor)

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© 1997 Springer Science+Business Media Dordrecht

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Zanetti, O., Bianchetti, A., Govoni, S., Trabucchi, M. (1997). Estrogen Replacement Therapy and Cognitive Functions in Elderly Women. In: Paoletti, R., Crosignani, P.G., Kenemans, P., Samsioe, G., Soma, M.R., Jackson, A.S. (eds) Women’s Health and Menopause. Medical Science Symposia Series, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5560-1_25

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  • DOI: https://doi.org/10.1007/978-94-011-5560-1_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6343-2

  • Online ISBN: 978-94-011-5560-1

  • eBook Packages: Springer Book Archive

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