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The Role of Structure in Complexes Between the p53 DNA Binding Domain and DNA Response Elements

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Genome Structure and Function

Part of the book series: NATO ASI Series ((ASHT,volume 31))

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Abstract

A recent cocrystal structure of a minimal core p53 DNA binding domain peptide (p53DBD) complexed with a DNA response element has provided valuable insights into the binding specificity of p53 by identifying specific binding contacts. However, many important questions remained unanswered by that study including the full complex size as well as the organization of p53 tetramers bound to the subcomponents of the DNA recognition site.

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Authors and Affiliations

  1. Department of Biochemistry/330, School of Medicine, University of Nevada Reno, Reno, NV, 89557, USA

    A. K. Nagaich, P. Balagurumoorthy, W. M. Miller & R. E. Harrington

  2. Laboratory of Cell Biology, USA

    E. Appella

  3. Laboratory of Mathematical Biology, NCI, National Institutes of Health, Bethesda, MD, 20892, USA

    V. B. Zhurkin

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  1. A. K. Nagaich
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  2. P. Balagurumoorthy
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  3. W. M. Miller
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  4. E. Appella
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  5. V. B. Zhurkin
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  6. R. E. Harrington
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Editors and Affiliations

  1. Institute of Biophysics, University of Genoa, Genoa, Italy

    Claudio Nicolini

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Nagaich, A.K., Balagurumoorthy, P., Miller, W.M., Appella, E., Zhurkin, V.B., Harrington, R.E. (1997). The Role of Structure in Complexes Between the p53 DNA Binding Domain and DNA Response Elements. In: Nicolini, C. (eds) Genome Structure and Function. NATO ASI Series, vol 31. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5550-2_9

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  • DOI: https://doi.org/10.1007/978-94-011-5550-2_9

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