Abstract
Corneal graft survival was assessed within a large prospectively collected database of 2103 consecutive corneal grafts in a single center. HLA Class I antigen matching significantly improved graft survival in no only high risk recipients (p < 0.001) but also in low risk recipients (p = 0.0001). This effect was also present in a subset of 606 Organ cultured donor corneas for high risk patients (p = 0.05). Graft failures were observed in 608 transplants, 45.5% were due to immunological rejection. The beneficial effect of HLA Class II antigen matching on graft survival in 233 high risk patients (p = 0.02) and in a subset of 99 herpes keratitis patients (p = 0.05) was found after exclusion of the patients with nonimmunological graft failures.
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Völker-Dieben, H.J., D’amaro, J. (1997). HLA Class I and Class II Matched Donor Material for Improved Corneal Allograft Survival. In: Madrigal, A.J., Bencová, M., Middleton, D., Charron, D., Nánási, T. (eds) Immunogenetics: Advances and Education. NATO ASI Series, vol 35. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5486-4_25
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DOI: https://doi.org/10.1007/978-94-011-5486-4_25
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