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Immunogenetics: Advances and Education pp 121–134Cite as

The Application of Cellular Tests in the Selection of Unrelated Donors for Bone Marrow Transplantation

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Part of the book series: NATO ASI Series ((ASHT,volume 35))

Abstract

Bone marrow transplants from genotypically human leucocyte antigens (HLA) identical sibling donors have been used successfully to treat patients with haematological malignancies and bone marrow failures. However, only 35% of patients have an HLA identical sibling donor. A small percentage of patients can be transplanted with an HLA phenotypically identical or partly identical family donor. For the remainder a phenotypically identical unrelated donor has to be found. Unfortunately, the incidence of acute graft-versus-host disease (GvHD) and rejection is significantly higher among recipients of marrow from phenotypically HLA identical unrelated donors than in recipients of marrow from HLA identical siblings. This is probably due to a higher number of “hidden” HLA and/or minor histocompatibility antigen differences between unrelated individuals, which are not detected by the standard tissue typing techniques i.e. serologic HLA typing and Class II DNA typing. Cellular tests may be used to detect such mismatches as they reflect the functional T cell repertoire recognizing the histocompatibility differences between donor and recipient.

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Author information

Authors and Affiliations

  1. Department of Immunohaematology & Blood Bank, Leiden University Hospital, Leiden, The Netherlands

    M. Oudshoorn, J. J. Van Rood, D. Lio, B. Koene, M. B. Ruigrok, M. F. J. V. D. Voort Maarschalk & F. H. J. Claas

  2. Europdonor Foundation, Leiden University Hospital, Leiden, The Netherlands

    M. Oudshoorn, J. J. Van Rood & J. L. W. T. Lie

Authors
  1. M. Oudshoorn
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  2. J. J. Van Rood
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  3. D. Lio
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  4. J. L. W. T. Lie
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  5. B. Koene
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  6. M. B. Ruigrok
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  7. M. F. J. V. D. Voort Maarschalk
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  8. F. H. J. Claas
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Editor information

Editors and Affiliations

  1. Anthony Nolan Research Institute, Royal Free Hospital, London, UK

    Alejandro J. Madrigal

  2. Slovak Foundation Education in Immunogenetics, Bratislava, Slovak Republic

    Margita Bencová

  3. Northern Ireland Tissue Typing Centre, City Hospital, Belfast, Ireland, UK

    Derek Middleton

  4. Institute des Cordeliers, HLA et Médecine, 12th IHWC Office, Paris, France

    Dominique Charron

  5. Slovak Academy of Sciences, Bratislava, Slovak Republic

    Tibor Nánási

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© 1997 Springer Science+Business Media Dordrecht

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Oudshoorn, M. et al. (1997). The Application of Cellular Tests in the Selection of Unrelated Donors for Bone Marrow Transplantation. In: Madrigal, A.J., Bencová, M., Middleton, D., Charron, D., Nánási, T. (eds) Immunogenetics: Advances and Education. NATO ASI Series, vol 35. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5486-4_14

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  • DOI: https://doi.org/10.1007/978-94-011-5486-4_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6308-1

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