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Biomolecular Structure and Dynamics: Recent Experimental and Theoretical Advances

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Biomolecular Structure and Dynamics

Part of the book series: NATO ASI Series ((NSSE,volume 342))

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Abstract

In the last decade NMR spectroscopy has become an important alternative to X-ray crystallography. The principal advantage of NMR is that it allows the study of biomolecules in solution, thus closer to their real physiological environment. The method is limited, however, to biomolecules of relatively small size due to limitations in spectral resolution and line broadening effects. The upper limit is presently situated around molecular weights of 30 kD. Knowledge of three-dimensional structures might lead, for example, to a better understanding of structure-function relationships or recognition processes. For this purpose, accurate structures are required and, as we shall see, the use of so-called relaxation matrix approaches provides a means to improve the accuracy of the method.

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Author notes

  1. A. M. J. J. Bonvin

    Present address: Laboratorium für Physikalische Chemie, ETH-Zentrum, CH-8092, Zürich, Switzerland

Authors and Affiliations

  1. Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands

    R. Kaptein, A. M. J. J. Bonvin & R. Boelens

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  1. R. Kaptein
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  2. A. M. J. J. Bonvin
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Editors and Affiliations

  1. CRESIMM, Lille, Villeneuve d’Ascq, France

    Gérard Vergoten

  2. Department of Chemistry, University of Science and Technology, Lille, Villeneuve d’Ascq, France

    Gérard Vergoten

  3. Chemical Engineering Department, National Technical University of Athens, Zografou, Athens, Greece

    Theophile Theophanides

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Kaptein, R., Bonvin, A.M.J.J., Boelens, R. (1997). Biomolecular Structure and Dynamics: Recent Experimental and Theoretical Advances. In: Vergoten, G., Theophanides, T. (eds) Biomolecular Structure and Dynamics. NATO ASI Series, vol 342. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5484-0_9

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  • DOI: https://doi.org/10.1007/978-94-011-5484-0_9

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