Abstract
Geometrical structures and stabilities of G•GC, T•AT, A •AT and C•GC nucleic acid triplets have been computed by using the AM1 and PM3 advanced semimpirical methods. Results indicate that the third nucleic acid base binds with the corresponding Watson-Crick base-pair via Hoogsteen hydrogen bonds. Where possible comparisons have been made with previous ab initio investigations.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
R. D. Wells, D. A. Collier, J. C. Hanvey, M. Shimizu and F. Wohlrab, FABES J. 2 (1988) 2939.
S. F. Singleton and P. B. Dervan, J. Am. Chem. Soc. 114 (1992) 6957.
G. Duval-Valentin, N. T. Thuong and C. Helene, Proc. Natl. Acad. Sci. USA 89 (1992) 504.
T. Ito, C. L. Smith and C. R. Cantor, Proc. Natl. Acad. Sci. USA 89 (1992) 495.
D. S. Pilch, C. Levenson and R. H. Dchafer, Biochemistry 30 (1991) 6081.
J. N. Davidson and W. E. Cohn (eds) Preogress in Nucleic Acid Research and Molecular Biology, Academic Press, New York, vol. 10, 1970.
A. Rich and V. L. Raybahnday, Ann. Rev. Biochem. 45 (1976) 805.
P. A. Beal and P. B. Dervan, J. Am. Chem. Soc. 114 (1992) 4976.
J. S. Koh and P. B. Dervan, J. Am. Chem. Soc. 114 (1992) 1470.
S.-P. Jiang, R. L. Jernigan, K.-L. Ting, J.-L. Syi and G. Raghunathan, J. Biomol. Struct. Dyn. 12 (1994) 383.
S. Weerasinghe, P. E. Smith, V. Mohan, Y.-K. Cheng and B. M. Pettitt, J. Am. Chem. Soc. 117 (1995) 2147.
M. Kamiya, H. Torigoe, H. Shind and A. Sarai, J. Am. Chem. Soc. 118 (1996) 4532.
H. E. Moser and P. B. Dervan, Scienze 238 (1987) 645.
T. Le Doan, L. Perronault, D. Prasenth, N. Habhoub, J. L. Decant, N. T. Thuong, J. Lhomme and C. Helene, Nucleic Acid Res. 15 (1987) 7749.
P. A. Bell and P. B. Dervan, Science 251 (1991) 1360.
P. Rajagopal and J. Feigon, Nature 339 (1989) 637.
C. de los Santos, M. Rosen and D. Patel, Biochemistry 28 (1989) 7282.
D. H. Live, I. Radhakrishnan, V. Misra and D. Patel, J. Am. Chem. Soc. 113 (1991) 4687.
K. Yoon, C. A. Hobbs, K. Koch, M. Sardaro, R. Kutny and A. L. Weis, Proc. Natl. Acad. Sci. USA 89 (1992) 3840 and references cited therein.
J.-S. Sun and C. Helene, Curr. Opin. Struct. Biol. 3 (1993) 345 and references cited therein.
M. J. S. Dewar and W. Thiel, J. Am. Chem. Soc. 98 (1977) 4899.
J. J. P. Stewart, J. Comp. Chem. 10 (1989) 209, ibidem 221.
M. J. S. Dewar and C. Cone, J. Am. Chem. Soc. 99 (1977) 372
M. J. S. Dewar, E. G. Zoebish, E. F. Healy and J. J. P. Stewart, J. Am. Chem. Soc. 107 (1985) 3902.
P. Davis, L. W. Burggraf and D. M. Storch, J. Comp. Chem. 12 (1990) 350.
J. J. P. Stewart, QCPE 455, Department of Chemistry, Indiana University, Bloomington, Indiana.
L. Katz, K. Tomita and A. Rich, Acta Cryst. 21 (1966) 754.
F. S. Matthews and A. Rich, J. Mol. Biol. 8 (1964) 89.
E. V. Haschemeyer and H. M. Sabel, Acta Cryst. 18 (1965) 525.
W. Saenger, Principles of Nucleic Acid Structure, Springer-Verlag, New York, 1984.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Marino, T., Russo, N., Sarubbo, A., Toscano, M. (1997). Geometries and Stabilities of G·GC, T·AT, A·AT an C·GC Nucleic Acid Base Triplets. In: Vergoten, G., Theophanides, T. (eds) Biomolecular Structure and Dynamics. NATO ASI Series, vol 342. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5484-0_15
Download citation
DOI: https://doi.org/10.1007/978-94-011-5484-0_15
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6307-4
Online ISBN: 978-94-011-5484-0
eBook Packages: Springer Book Archive