Abstract
Autoantibodies to neutrophilic granulocytes have been known under the name ‘granulocyte-specific antinuclear antibodies’ (GS-ANA) since the mid 1960s [1, 2]. Although recognized as early as 1973 [3], autoantibodies to cytoplasmic antigens of neutrophils were not described in literature until 1982 [4]. The morphology and content of a granulocyte is given in Fig. 1. Autoantibodies to surface components of neutrophils are considered to be extremely rare, and neutropenias found in relation to autoimmune diseases are most likely induced by circulating immune complexes interacting with and thereby activating neutrophils [5, 6, 7].
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Abbreviations
- ANCA:
-
anti-neutrophil cytoplasmic antibodies
- cANCA:
-
cytoplasmic ANCA
- IIF:
-
indirect immunofluorescence
- EIA:
-
enzyme immuno assay
- MPO:
-
myeloperoxidase
- PR-3:
-
proteinase-3
- GS-ANA:
-
granulocyte-specific antinuclear antibodies
References
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© 1993 Springer Science+Business Media Dordrecht
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Wiik, A., Rasmussen, N., Wieslander, J. (1993). Methods to detect autoantibodies to neutrophilic granulocytes. In: Van Venrooij, W.J., Maini, R.N. (eds) Manual of Biological Markers of Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5444-4_9
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DOI: https://doi.org/10.1007/978-94-011-5444-4_9
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