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Mitochondrial autoantigens

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Manual of Biological Markers of Disease

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Abstract

Subunits of the 2-oxo-acids dehydrogenase complexes. These include:

  1. a)

    Dihydrolipoamide acetyltransferase (EC 2.2.1.12); the E2 subunit of pyruvate dehydrogenase [1, 2]

  2. b)

    The E2 subunit of branched chain-keto acids dehydrogenase complex, (branched chain 2-oxo-acid dehydrogenase complex) [2]

  3. c)

    The E2 subunit of α-ketoglutarate acid dehydrogenase (2-oxo-glutarate acid dehydrogenase complex) [3]

  4. d)

    Protein X [4]

  5. e)

    PDC-E1α and PDC-E1β [5]

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Abbreviations

AMA:

Anti-mitochondrial antibodies

BCKD:

Branched chain α-keto acids dehydrogenase

BCOADC:

Branched chain 2-oxo-acid dehydrogenase complex

KGDC:

α-ketoglutarate acid dehydrogenase complex

OGDC:

2-oxo-glutarate acid dehydrogenase complex

PBC:

Primary Biliary Cirrhosis

PDC:

Pyruvate dehydrogenase complex

PBS:

Phosphate buffered saline

PDH:

Pyruvate dehydrogenase

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Author information

Authors and Affiliations

  1. Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, TB 192, School of Medicine, Davis, CA, 95616, USA

    Patrick S. C. Leung & M. Eric Gershwin

  2. Centre for Molecular Biology and Medicine, Monash University, Clayton, Victoria, 3168, Australia

    Ian Mackay

Authors
  1. Patrick S. C. Leung
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  2. Ian Mackay
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  3. M. Eric Gershwin
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Editor information

Editors and Affiliations

  1. University of Nijmegen, The Netherlands

    W. J. Van Venrooij

  2. The Mathilda and Terence Kennedy Institute of Rheumatology, London, UK

    R. N. Maini

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Leung, P.S.C., Mackay, I., Gershwin, M.E. (1994). Mitochondrial autoantigens. In: Van Venrooij, W.J., Maini, R.N. (eds) Manual of Biological Markers of Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5444-4_19

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  • DOI: https://doi.org/10.1007/978-94-011-5444-4_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-4243-4

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