Skip to main content
SpringerLink
Log in
Book cover

Manual of Biological Markers of Disease pp 431–491Cite as

Scleroderma-associated antigens

  • Chapter

Abstract

As much as 95 to 98% of scleroderma patients have been shown to produce autoantibodies to nuclear, nucleolar or mitochondrial antigens [1–3]. These serologic markers have been shown to be useful in diagnosis and identifying disease subsets [3–5]. A number of autoantigens in scleroderma have been described. The most important are: DNA topoisomerase I (110 kDa) [3, see also this Manual, chapter B-5.1], the centromere proteins CENP-A (17 kDa), CENP-B (80 kDa) and CENP-C (140 kDa) [3, 5, see also this Manual chapter B-5.2], the small nucleolar RNA (snoRNA) associated protein fibrillarin (34 kDa) [3, 5, see also this Manual, chapter B-5.3], the 210 kDa protein component of the RNA polymerase I complex [3, 5], a 40 kDa protein associated with the 7–2 RNP complex [3, 6], nucleolin (110 kDa) [7], a 70 kDa protein of the mitochondrial M2 complex [3, 8], and a nucleolus-organizing region (NOR) associated 90 kDa protein (NOR-90) [3, 9], recently identified as transcription factor hUBF (human upstream binding factor) [10].

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bernstein RM, Steigerwald JC & Tan EM (1982) Clin Exp Immunol 48: 43–51

    PubMed  CAS  Google Scholar 

  2. Steen VD, Powell DL & Medsger TA Jr (1988) Arthritis Rheum 31: 196–203

    Article  PubMed  CAS  Google Scholar 

  3. Reimer G (1990) In: LeRoy EC (ed) Rheumatic disease clinics of North America Vol 16(1), pp 169–183. WB Saunders Company, Philadelphia

    Google Scholar 

  4. Tan EM (1982) Adv Inununol 33: 167–240

    Article  CAS  Google Scholar 

  5. Tan EM (1989) Adv Immunol 44: 93–152

    Article  PubMed  CAS  Google Scholar 

  6. Kipnis RJ, Craft J & Hardin JA (1990) Arthritis Rheum 33: 1431–1437

    Article  PubMed  CAS  Google Scholar 

  7. Minota S, Jarjour WN, Suziki N, Nojima Y, Roubey RAS, Mimura T, Yamada A, Hosoya T, Takaku F & Winfield JB (1991) J Immunol 146: 2249–2252

    PubMed  CAS  Google Scholar 

  8. Freqeau DR, Leung PSC, Coppel RL, McNeilage LJ, Medsger TA Jr & Gershwin ME (1988) Arthritis Rheum 31: 386–392

    Article  Google Scholar 

  9. Rodriquez-Sanchez JL, Gelpi C, Juarez C & Hardin JA (1987) J Immunol 139: 2579–2584

    Google Scholar 

  10. Chan EKL, Imai H, Hamel JC & Tan EM (1991) J Exp Med 174: 1239–1244

    Article  PubMed  CAS  Google Scholar 

  11. Alderuccio F, Chan EKL & Tan EM (1991) J Exp Med 173: 941–952

    Article  PubMed  CAS  Google Scholar 

  12. Reimer G, Scheer U, Peters J-M & Tan EM (1986) J Immunol 137: 3802–3808

    PubMed  CAS  Google Scholar 

  13. Mimori T, Hardin JA & Steitz JA (1986) J Biol Chem 261: 2274–2278

    PubMed  CAS  Google Scholar 

  14. Reeves WH & Sthoeger ZM (1989) J Biol Chem 264: 5047–5052

    PubMed  CAS  Google Scholar 

  15. Yaneva M, Wen J, Ayala A & Cook R (1989) J Biol Chem 264: 13407–13411

    PubMed  CAS  Google Scholar 

  16. Stuiver MH, Coenjaerts FEJ & van der Vliet PC (1990) J Exp Med 172: 1049–1054

    Article  PubMed  CAS  Google Scholar 

  17. Mimori T, Akizuki M, Yamagata H & Inada S (1981) J Clin Invest 68: 611–620

    Article  PubMed  CAS  Google Scholar 

References

  1. Douvas AS, Achten M & Tan EM (1979) J Biol Chem 254: 10514–10522

    PubMed  CAS  Google Scholar 

  2. Kumar V, Kowalewski C, Koelle M, Qutaishat S, Chorzelski TP, Beutner EH, JarzabekChorzelska M, Kolacinska Z & Jablonska S (1988) J Rheumatol 15: 1499–1502

    PubMed  CAS  Google Scholar 

  3. van Venrooij WJ, Stapel SO, Houben H, Habets WJ, Kallenberg CGM, Penner E & van de Putte LB (1985) J Clin Invest 75: 1053–1060

    Article  PubMed  Google Scholar 

  4. Tan EM (1982) Adv Immunol 33: 167–240

    Article  PubMed  CAS  Google Scholar 

  5. Tan EM (1989) Adv Immunol 44: 93–152

    Article  PubMed  CAS  Google Scholar 

  6. Maul GG, French BT, van Venrooij WJ & Jiminez SA (1986) Proc Natl Acad Sci USA 83: 5145–5149

    Article  PubMed  CAS  Google Scholar 

  7. Muller MT, Pfund WP, Mehta VB & Trask DK (1985) EMBO J 4: 1237–1243

    PubMed  CAS  Google Scholar 

  8. Oddou P, Schmidt U, Knippers R & Richter A (1988) Eur J Biochem 177: 523–529

    Article  PubMed  CAS  Google Scholar 

  9. Negri C, Chiesa R, Cerino A, Bestagno M, Sala C, Zini N, Maraldi NM & Astaldi Ricotti GCB (1992) Exp Cell Res 200: 452–459

    Article  PubMed  CAS  Google Scholar 

  10. Ghirardello A, Ruffatti A, Calligaro A, Del Ross T & Gambari PF (1992) Clin Rheum 11:126

    Google Scholar 

  11. Hildebrandt S, Weiner E, Senécal J-L, Noell S, Daniels L, Earnshaw WC & Rothfield NF (1990) Arthritis Rheum 33: 724–727

    Article  PubMed  CAS  Google Scholar 

  12. Kipnis RJ, Craft J, Hardin JA (1990) Arthritis Rheum 33: 1431–1437

    Article  PubMed  CAS  Google Scholar 

  13. Juarez C, Vila JL, Gelpi C, Agusti M, Amengual MJ, Martinez MA & Rodriquez JL (1988) Arthritis Rheum 31: 108–115

    Article  PubMed  CAS  Google Scholar 

  14. Hildebrandt S, Noell GS, Vazquez-Abad D, Earnshaw WC, Zanetti M & Rothfield NF (1991) Autoimmunity 10: 41–48

    Article  PubMed  CAS  Google Scholar 

  15. Verheijen R, de Jong BAW & van Venrooij WJ (1992) Clin Exp Immunol 89: 456–460

    Article  PubMed  CAS  Google Scholar 

  16. Heck MMS, Hittelman WN & Earnshaw WC (1988) Proc Natl Acad Sci USA 85: 1086–1090

    Article  PubMed  CAS  Google Scholar 

  17. Wang JC (1985) Ann Rev Biochem 54: 665–697

    Article  PubMed  CAS  Google Scholar 

  18. Osheroff N (1989) Pharmacol Ther 41: 223–241

    Article  PubMed  CAS  Google Scholar 

  19. Meesters TM, Hoet M, van den Hoogen F, Verheijen R, Richter A, Habets WJ & van Venrooij WJ (1992) Mol Biol Rep 16: 117–123

    Article  PubMed  CAS  Google Scholar 

  20. D’Arpa P, Machlin PS, Ratrie H, Rothfield NF, Cleveland DW & Earnshaw WC (1988) Proc Natl Acad Sci USA 85:2543–2547

    Article  PubMed  Google Scholar 

  21. Kunze N, Yang GC, Jiang ZY, Hameister H, Adolph S, Wiedorn K-H, Richter A & Knippers R (1989) Hum Genet 84: 6–10

    Article  PubMed  CAS  Google Scholar 

  22. Kunze N, Yang G. Dölberg M, Sundarp R, Knippers R & Richter A (1991) J Biol Chem 266: 9610–9616

    PubMed  CAS  Google Scholar 

  23. Maul GG, Jimenez SA, Riggs E & Ziemnicka-Kotula (1989) Proc Natl Acad Sci USA 86: 8492–8496

    Article  PubMed  CAS  Google Scholar 

  24. Zhou BS, Bastow KF & Cheng Y (1989) Cancer Res 49: 3922–3927

    PubMed  CAS  Google Scholar 

  25. Zechiedrich EL & Osheroff N (1990) EMBO J 9: 4555–4562

    PubMed  CAS  Google Scholar 

  26. Barrett JF, Sutcliffe JA & Gootz TD (1990) Antimicrobial Agents and Chemotherapy 34:1–7

    Article  PubMed  CAS  Google Scholar 

  27. Eng W-K, Pandit SD & Sternglanz R (1989) J Biol Chem 264: 13373–13376

    PubMed  CAS  Google Scholar 

  28. Lynn RM, Bjornsti M-A, Caron PR & Wang JC (1989) Proc Natl Acad Sci USA 86: 3559–3563

    Article  PubMed  CAS  Google Scholar 

  29. Hsiang Y-H, Hertzberg R, Hecht S & Liu LF (1985) J Biol Chem 260:14873–14878

    PubMed  CAS  Google Scholar 

  30. Gilmour DS & Elgin SC (1987) Mol Cell Biol 7: 141–148

    PubMed  CAS  Google Scholar 

  31. Zhang H, Wang JC & Liu LF (1988) Proc Natl Acad Sci USA 85: 1060–1064

    Article  PubMed  CAS  Google Scholar 

  32. Douvas A, Lambie PB, Turman MA, Nitahara KS & Hammond L (1991) Biochem Biophys Res Commun 178:414–421

    Article  PubMed  CAS  Google Scholar 

  33. Pommier Y, Kerrigan D, Hartman KD & Glazer RI (1990) J Biol Chem 265: 9418–9422

    PubMed  CAS  Google Scholar 

  34. Samuels DS, Shimizu Y & Shimizu N (1989) FEBS Lett 259: 57–60

    Article  PubMed  CAS  Google Scholar 

  35. Uemura T & Yanagida M (1984) EMBO J 3:1737–1744

    PubMed  CAS  Google Scholar 

  36. Thrash C, Bankier AT, Barrell BG & Sternglanz R (1985) Proc Natl Acad Sci USA 82: 4374–4378

    Article  PubMed  CAS  Google Scholar 

  37. Snapka RM (1986) Mol Cell Biol 6: 4221–4227

    PubMed  CAS  Google Scholar 

  38. Yang L, Wold MS, Li JJ, Kelly TJ & Liu LF (1987) Proc Natl Acad Sci USA 84: 950–954

    Article  PubMed  CAS  Google Scholar 

  39. Bullock P, Champoux JJ & Botchan M (1985) Science 230: 954–958

    Article  PubMed  CAS  Google Scholar 

  40. McCroubrey WK Jr & Champoux JJ (1986) J Biol Chem 261: 5130–5137

    Google Scholar 

  41. Christiansen K, Boven BJ & Westergaard O (1987) J Mol Biol 193: 517–525

    Article  PubMed  CAS  Google Scholar 

  42. Ness JP, Koller T & Thoma F (1988) J Mol Biol 200: 127–139

    Article  PubMed  CAS  Google Scholar 

  43. Gilmour DS, Pflugfelder G, Wang JC & Lis JT (1986) Cell 44: 401–407

    Article  PubMed  CAS  Google Scholar 

  44. Stewart AF & Schütz G (1987) Cell 50: 1109–1117

    Article  PubMed  CAS  Google Scholar 

  45. Verheijen R (1992) Mol Biol Rep 16: 183–189

    Article  PubMed  CAS  Google Scholar 

  46. Verheijen R, van den Hoogen F, Beijer R, Richter A, Penner E, Habets WJ & van Venrooij WJ (1990) Clin Exp Immunol 80: 38–43

    Article  PubMed  CAS  Google Scholar 

  47. D’Arpa P, White-Cooper H, Cleveland DW, Rothfield NF & Earnshaw WC (1990) Arthritis Rheum 33: 1501–1511

    Article  PubMed  Google Scholar 

  48. Piccinini G, Cardellini E, Reimer G, Arnett FC & Durban E (1991) Mol Immunol 28: 333–339

    Article  PubMed  CAS  Google Scholar 

  49. Kuwana M, Kaburaki J, Mimori T, Tojo T & Homma M (1993) Arthritis Rheum 36: 1406–1413

    Article  PubMed  CAS  Google Scholar 

References

  1. Moroi Y, Peebles C, Fritzler MJ, Steigerwald J & Tan EM (1980) Proc Natl Acad Sci USA 77: 1627–1631

    Article  PubMed  CAS  Google Scholar 

  2. Earnshaw WC & Rothfield N (1985) Chromosoma 91: 313–321

    Article  PubMed  CAS  Google Scholar 

  3. Valdivia MM & Brinkley BR (1985) J Cell Biol 101: 1124–1134

    Article  PubMed  CAS  Google Scholar 

  4. Earnshaw W, Bordwell B, Marino C & Rothfield N (1986) J Clin Invest 77: 426–430

    Article  PubMed  CAS  Google Scholar 

  5. Tan EM (1982) Adv Immunol 33: 167–240

    Article  PubMed  CAS  Google Scholar 

  6. Tan EM (1989) Adv Immunol 44: 93–152

    Article  PubMed  CAS  Google Scholar 

  7. Rothfield N, Whitaker D, Bordwell B, Weiner E, Senécal J-L & Earnshaw W (1987) Arthritis Rheum 30: 1416–1419

    Article  PubMed  CAS  Google Scholar 

  8. Hildebrandt S, Weiner E, Senécal J-L, Noell S, Daniels L, Earnshaw WC & Rothfield NF (1990) Arthritis Rheum 33: 724–727

    Article  PubMed  CAS  Google Scholar 

  9. Muro Y, Sugimoto K, Okazaki T & Ohashi M (1990) J Rheum 17:1042–1047

    PubMed  CAS  Google Scholar 

  10. Earnshaw WC, Sullivan KF, Machlin PS, Cooke CA, Kaiser DA, Pollard TD, Rothfield NF & Cleveland DW (1987) J Cell Biol 104: 817–829

    Article  PubMed  CAS  Google Scholar 

  11. Earnshaw WC, Machlin PS, Bordwell BJ, Rothfield NF & Cleveland DW (1987) Proc Natl Acad Sci USA 84: 4979–4983

    Article  PubMed  CAS  Google Scholar 

  12. Verheijen R, de Jong BAW, Oberyé EHH & van Venrooij WJ (1992) Mol Biol Rep 16: 49–59

    Article  PubMed  CAS  Google Scholar 

  13. Pluta AF, Cooke CA & Earnshaw EC (1990) Trends Biochem 15: 181–185

    Article  CAS  Google Scholar 

  14. Willard HF (1990) Trends Genet 6: 410–416

    Article  PubMed  CAS  Google Scholar 

  15. Rattner JB (1991) BioEssays 13: 51–56

    Article  PubMed  CAS  Google Scholar 

  16. Ochs RL & Press RI (1992) Exp Cell Res 200: 339–350

    Article  PubMed  CAS  Google Scholar 

  17. Palmer DK, O’Day K, Wener MH, Andrews BS & Margolis RL (1987) J Cell Biol 104: 805–815

    Article  PubMed  CAS  Google Scholar 

  18. Palmer DK, O’Day K, Trong HL, Charbonneau H & Margolis RL (1991) Proc Natl Acad Sci USA 88: 3734–3738

    Article  PubMed  CAS  Google Scholar 

  19. Masumoto H, Masukata H, Muro Y, Nozaki N & Okazaki T (1989) J Cell Biol 109: 1963–1973

    Article  PubMed  CAS  Google Scholar 

  20. Yoda K, Kitagawa K, Masumoto H, Muro Y & Okazaki T (1992) J Cell Biol 119: 1413–1427

    Article  PubMed  CAS  Google Scholar 

  21. Pluta AF, Saitoh N, Goldberg I & Earnhaw WC (1992) J Cell Biol 116: 1081–1093

    Article  PubMed  CAS  Google Scholar 

  22. Sugimoto K, Muro Y & Himeno M (1992) J Biochem 111: 478–483

    PubMed  CAS  Google Scholar 

  23. Cooke CA, Bernat RL & Earnshaw WC (1990) J Cell Biol 110: 1475–1488

    Article  PubMed  CAS  Google Scholar 

  24. Willard HF & Waye JS (1987) Trends Genet 3: 192–198

    Article  CAS  Google Scholar 

  25. Saitoh H. Tomkiel J, Cooke CA, Ratrie H, Maurer M, Rothfield NF & Earnshaw WC (1992) Cell 70: 115–125

    Article  PubMed  CAS  Google Scholar 

  26. Kingwell B & Rattner JB (1987) Chromosoma 95: 403–407

    Article  PubMed  CAS  Google Scholar 

  27. Kremer L, Del Mazo J & Avila J (1988) Eur J Cell Biol 46: 196–199

    PubMed  CAS  Google Scholar 

  28. Palmer DK, O’Day K & Margolis RL (1990) Chromosoma 100: 32–36

    Article  PubMed  CAS  Google Scholar 

  29. Sullivan KF & Glass CA (1991) Chromosoma 100: 360–370

    Article  PubMed  CAS  Google Scholar 

  30. Sugimoto K & Himeno M (1991) Agric Biol Chem. 55: 2687–2692

    Article  PubMed  CAS  Google Scholar 

  31. Verheijen R (1992) Mol Biol Rep 16: 183–189

    Article  PubMed  CAS  Google Scholar 

  32. Rattner JB, Lew J & Wang JH (1990) Cell Motility and the Cytoskeleton 17: 227–236

    Article  PubMed  CAS  Google Scholar 

  33. Moreno S & Nurse P (1990) Cell 61: 549–551

    Article  PubMed  CAS  Google Scholar 

  34. Sturgill TW & Wu J (1991) Biochim Biophys Acta 1092: 350–357

    Article  PubMed  CAS  Google Scholar 

  35. Robbins J, Dilworth SM, Laskey RA & Dingwall C (1991) Cell 64: 615–623

    Article  PubMed  CAS  Google Scholar 

  36. Joly JC, Flynn G & Purich DL (1989) J Cell Biol 109: 2289–2294

    Article  PubMed  CAS  Google Scholar 

  37. Sugimoto K, Migita H, Hagishita Y, Yata H & Himeno M (1992) Cell Structure and Function 17: 129–138

    Article  PubMed  CAS  Google Scholar 

References

  1. Lischwe MA, Ochs RL, Reddy R, Cook RG, Yeoman LC, Tan EM, Reichlin M & Busch H (1985) J Biol Chem 260: 14304–14310

    PubMed  CAS  Google Scholar 

  2. Ochs RL, Lischwe MA, Spohn WH & Busch H (1985) Biol Cell 54: 123–134

    Article  PubMed  CAS  Google Scholar 

  3. Christensen ME, Moloo J, Swischuk JL & Schelling ME (1986) Exp Cell Res 166: 77–93

    Article  PubMed  CAS  Google Scholar 

  4. Schimmang T, Tollervey D, Kern H, Frank R & Hurt EC (1989) EMBO J 8: 4015–4024

    PubMed  CAS  Google Scholar 

  5. Okano Y, Steen VD & Medsger TA Jr (1992) Arthritis Rheum 35: 95–100

    Article  PubMed  CAS  Google Scholar 

  6. Kipnis RJ, Craft J & Hardin JA (1990) Arthritis Rheum 33: 1431–1437

    Article  PubMed  CAS  Google Scholar 

  7. Tyc K & Steitz JA (1989) EMBO J 8: 3113–3119

    PubMed  CAS  Google Scholar 

  8. Verheijen R, Wiik A, de Jong BAW, Heier-Madsen M, Ullman S, Halberg P & van Venrooij WJ (1994) J Immunol Methods 169: 173–182

    Article  PubMed  CAS  Google Scholar 

  9. Puvion-Dutilleul F, Mazan S, Nicoloso M & Christensen ME (1991) Eur J Cell Biol 56: 178–186

    PubMed  CAS  Google Scholar 

  10. Raska I, Andrade LEC, Ochs RL, Chan EKL, Chang CM, Roos G & Tan EM (1991) Exp Cell Res 195: 27–37

    Article  PubMed  CAS  Google Scholar 

  11. Tollervey D, Lehtonen H, Jansen R, Kern H & Hurt EC (1993) Cell 72: 443–457

    Article  PubMed  CAS  Google Scholar 

  12. Filipowicz W & Kiss T. (1993) Mol Biol Rep 18: 149–156

    Article  PubMed  CAS  Google Scholar 

  13. Fournier MJ & Maxwell ES (1993) Trends Biochem 18: 131–135

    Article  CAS  Google Scholar 

  14. Mattaj IW, Tollervey D & Séraphin B (1993) FASEB J 7: 47–53

    PubMed  CAS  Google Scholar 

  15. Aris JP & Blobel G (1991) Proc Natl Acad Sci USA 88: 931–935

    Article  PubMed  CAS  Google Scholar 

  16. Turley SJ, Tan EM & Pollard KM (1993) Biochim Biophys Acta 1216: 119–122

    Article  PubMed  CAS  Google Scholar 

  17. Lapeyre B, Mariottini P, Mathieu C, Ferrer P, Amaldi F, Amalric F & Caizergues-Ferrer M (1990) Mol Cell Biol 10: 430–434

    PubMed  CAS  Google Scholar 

  18. Baserga SJ, Yang XW & Steitz JA (1991) EMBO J 10: 2645–2651

    PubMed  CAS  Google Scholar 

  19. Baserga SJ, Gilmore-Hebert M & Yang XW (1992) Genes Dev 6: 1120–1130

    Article  PubMed  CAS  Google Scholar 

  20. Query CC, Bentley RC & Keene JD (1989) Cell 57: 89–101

    Article  PubMed  CAS  Google Scholar 

  21. Bandziulus RJ, Swanson MS & Dreyfuss G (1989) Genes Dev 3: 431–437

    Article  Google Scholar 

  22. Parker KA & Steitz JA (1987) Mol Cell Biol 7: 2899–2913

    PubMed  CAS  Google Scholar 

  23. Celis JE, Rasmusssen HH, Madsen P, et al.(1992) Electrophoresis 13: 893–959

    Article  PubMed  CAS  Google Scholar 

  24. Najbauer J, Johnson BA, Young AL & Aswad DW (1993) J Biol Chem 268: 10501–10509

    PubMed  CAS  Google Scholar 

  25. Reimer G, Pollard KM, Penning CA, Ochs RL, Lischwe MA, Busch H & Tan EM (1987) Arthritis Rheum 30: 793–800

    Article  PubMed  CAS  Google Scholar 

  26. Reuter R, Tessars G, Vohr H-W, Gleichmann E & Lührmann R (1989) Proc Natl Acad Sci USA 86: 237–241

    Article  PubMed  CAS  Google Scholar 

  27. Kiledjian M & Dreyfuss G (1992) EMBO J 11: 2655–2664

    PubMed  CAS  Google Scholar 

  28. Girard J-P, Lehtonen H, Caizergues-Ferrer M, Amalric F, Tollervey D & Lapeyre B (1992) EMBO J 11: 673–682

    PubMed  CAS  Google Scholar 

  29. Russell ID & Tollervey D (1992) J Cell Biol 119: 737–747

    Article  PubMed  CAS  Google Scholar 

  30. Ghisolfi L, Joseph G, Amalric F & Erard M (1992) J Biol Chem 267: 2955–2959

    PubMed  CAS  Google Scholar 

  31. Reddy R & Busch H (1988) In: Birnstiel ML (ed) Structure and Function of Small Nuclear Ribonucleoprotein Particles, pp 1–37. Springer Verlag, Berlin

    Chapter  Google Scholar 

  32. Kass S, Tyc K, Steitz JA & Sollner-Webb B (1990) Cell 60: 897–908

    Article  PubMed  CAS  Google Scholar 

  33. Savino R & Gerbi SA (1990) EMBO J 8: 2299–2308

    Google Scholar 

  34. Tyc K & Steitz JA (1992) Nucleic Acids Res 20: 5375–5382

    Article  PubMed  CAS  Google Scholar 

  35. Reddy R, Henning D & Busch H (1985) J Biol Chem 260: 10930–10935

    PubMed  CAS  Google Scholar 

  36. Peculis BA & Steitz JA (1993) Cell 73: 1233–1245

    Article  PubMed  CAS  Google Scholar 

  37. Shanab GM & Maxwell ES (1991) Nucleic Acids Res 19: 4891–4894

    Article  PubMed  CAS  Google Scholar 

  38. Liu J & Maxwell ES (1990) Nucleic Acids Res 18: 6565–6571

    Article  PubMed  CAS  Google Scholar 

  39. Leverette R, Andrews M & Maxwell ES (1992) Cell 71: 1215–1221

    Article  PubMed  CAS  Google Scholar 

  40. Fragapane P, Prislei S, Michienzi A, Caffarelli E & Bozzoni I (1993) EMBO J 12: 2921–2929

    PubMed  CAS  Google Scholar 

  41. Fragapane P, Prislei S, Michienzi A, Caffarelli E & Bozzoni I (1993) EMBO J 12: 2921–2929

    PubMed  CAS  Google Scholar 

  42. Christensen ME & Banker N (1992) Cell Biol Int Rep 16: 1119–1131

    Article  PubMed  CAS  Google Scholar 

  43. Tycowski KT, Shu MD & Steitz JA (1993) Genes Dey 7: 1176–1190

    Article  CAS  Google Scholar 

References

  1. Reichlin M & Mattioli M (1976) Description of a serological reaction characteristic of polymyositis. Clin Immunol Immunopathol 5: 12–20

    Article  PubMed  CAS  Google Scholar 

  2. Wolfe JF, Adelstein E & Sharp GC (1977) Antinuclear antibody with distinct specificity for polymyositis. J Clin Invest 59: 176–178

    Article  PubMed  CAS  Google Scholar 

  3. Bernstein RM, Bunn CC, Hughes GRV, Francoeur AM & Mathews MB (1984) Cellular protein and RNA antigens in autoimmune diseases. Mol Biol Med 2: 105–120

    PubMed  CAS  Google Scholar 

  4. Targoff IN & Reichlin M (1985) Nucleolar localization of the PM-Scl antigen. Arthritis Rheum 28: 226–230

    Article  PubMed  CAS  Google Scholar 

  5. Reimer G, Scheer U, Peters JM & Tan EM (1986) Immunolocalization and partial characterization of a nucleolar autoantigen (PM-Scl) associated with polymyositis/ scleroderma overlap syndromes. J Immunol 137: 3802–3808

    PubMed  CAS  Google Scholar 

  6. Reimer G, Steen VD, Penning CA, Medsger TA & Tan EM (1988) Correlates between autoantibodies to nucleolar antigens and clinical features in patients with systemic sclerosis (scleroderma). Arthritis Rheum 31: 525–532

    Article  PubMed  CAS  Google Scholar 

  7. Gelpi C, Alguero A, Angeles Martinez M, Vidal S, Juarez C & Rodriguez-Sanchez JL (1990) Identification of protein components reactive with anti-PM/Sc1 autoantibodies. Clin Exp Immunol 81: 59–64

    Article  PubMed  CAS  Google Scholar 

  8. Kipins RJ, Craft J & Hardin JA (1990) The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays. Arthritis Rheum 33: 1431–1437

    Article  Google Scholar 

  9. Alderuccio F, Chan EKL & Tan EM (1991) Molecular characterization of an autoantigen of PM-Scl in the Polymyositis/Scleroderma overlap syndrome: A unique and complete human eDNA encoding an apparent 75-kD acidic protein of the nucleolar complex. J Exp Med 173: 941–952

    Article  PubMed  CAS  Google Scholar 

  10. Blüthner M & Bautz FA (1992) Cloning and characterization of the cDNA coding for a polymyositis-scleroderma overlap syndrome-related nucleolar 100-kD protein. J Exp Med 176: 973–980

    Article  PubMed  Google Scholar 

  11. Ge Q, Frank MB, O’Brien C & Targoff IN (1992) Cloning of a complementary DNA coding for the 100-kD antigenic protein of the PM-Scl autoantigen. J Clin Invest 90: 559–570

    Article  PubMed  CAS  Google Scholar 

  12. Bautz FA, Haidmann L & Genth E (1988) Nucleolar autoantibodies in patients with polymyositis-scleroderma overlap syndrome. Z Rheumatol 47: 314

    Google Scholar 

  13. Brendel V, Dohlman J, Blaisdel BE & Karlin S (1991) Very long charge runs in systemic lupus erythematosus-associated autoantigens. Proc Natl Acad Sci USA 88: 1536–1539

    Article  PubMed  CAS  Google Scholar 

  14. Tan EM (1989) Antinuclear antibodies: Diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 44: 93–151

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Nijmegen, The Netherlands

    W. J. Van Venrooij

  2. The Mathilda and Terence Kennedy Institute of Rheumatology, London, UK

    R. N. Maini

Authors
  1. W. J. Van Venrooij
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. N. Maini
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Nijmegen, The Netherlands

    W. J. Van Venrooij

  2. The Mathilda and Terence Kennedy Institute of Rheumatology, London, UK

    R. N. Maini

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Van Venrooij, W.J., Maini, R.N. (1994). Scleroderma-associated antigens. In: Van Venrooij, W.J., Maini, R.N. (eds) Manual of Biological Markers of Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5444-4_16

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-5444-4_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-4243-4

  • Online ISBN: 978-94-011-5444-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation