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DNA as antigen in SLE

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Manual of Biological Markers of Disease

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Abstract

Desoxyribonucleic acid (DNA) is an important antigen in the field of autoimmune diseases [1–3]. DNA as antigen may either be double-stranded (dsDNA) or single-stranded (ssDNA); the influence of DNA strands will be further discussed in paragraph 14. Furthermore, DNA as antigen will in vivo almost always occur in the form of nucleosomes, i.e. closely associated with histones.

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Abbreviations

(m)Ab:

(monoclonal) antibodies

BSA:

bovine serum albumin

(ds/ss)DNA:

(double-stranded/single-stranded) desoxyribonucleic acid

ELISA:

enzyme-linked immunosorbent assay

GVHD:

graft-versus-host disease

IFT:

immunofluorescence test

IgG/M:

immunoglobulin G/M

MW:

molecular weight

RIA:

radio immunoassay

RNA:

ribonucleic acid

RNP:

ribonucleoprotein

SLE:

systemic lupus erythematosus

UV:

ultraviolet

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Authors and Affiliations

  1. Department of Autoimmune Diseases, Central Laboratory of the Netherlands Red Cross Blood Transfusion Services, Amsterdam, The Netherlands

    Ruud J. T. Smeenk

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  1. University of Nijmegen, The Netherlands

    W. J. Van Venrooij

  2. The Mathilda and Terence Kennedy Institute of Rheumatology, London, UK

    R. N. Maini

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Smeenk, R.J.T. (1994). DNA as antigen in SLE. In: Van Venrooij, W.J., Maini, R.N. (eds) Manual of Biological Markers of Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5444-4_13

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