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Primary dysfunction after orthotopic liver transplantation

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Procurement, Preservation and Allocation of Vascularized Organs

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Abstract

In the last decade liver transplantation has emerged from clinical experimentation to become an accepted means of treatment for end stage liver disease [1–4]. The development of new immunosuppressants and enhanced modalities to treat postoperative rejection and infection have significantly increased patient and graft survival. The improved results mean that many adults and children with end stage liver disease are able to resume a nearly normal life after successful transplantation. In the last 10 years the number of liver transplants performed per year has increased from approximately 600 to more than 3000 in the USA and from 200 to 1500 in Europe. One of the factors which contributed significantly to this expansion was the introduction of the University of Wisconsin (UW) solution by Belzer and colleagues in 1986 [5–7]. With this new preservation solution the donor liver, pancreas, kidneys and small bowel could be flushed and cold-stored for a period sufficiently long to allow long distance procurement, organ sharing on an international scale, improved recipient preparation and implantation of organs without major detrimental effects on the immediate function after transplantation [8–10]. Also, with an increasing demand for donor livers suitable for pediatric recipients, livers could now be evaluated and reduced or even split during lengthy back-table procedures [11–13].

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Authors
  1. Rutger J. Ploeg
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Editors and Affiliations

  1. Department of Transplantation, California Pacific Medical Center, San Francisco, California, USA

    G. M. Collins

  2. Transplantation Pavillon V, Hôpital Edouard Herriot, Lyon, France

    J. M. Dubernard

  3. Division of Transplant Surgery, Department of Surgery, Klinikum Grosshadern, University of Munich, Munich, Germany

    W. Land

  4. Eurotransplant Foundation, Leiden, The Netherlands

    G. G. Persijn

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Ploeg, R.J. (1997). Primary dysfunction after orthotopic liver transplantation. In: Collins, G.M., Dubernard, J.M., Land, W., Persijn, G.G. (eds) Procurement, Preservation and Allocation of Vascularized Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5422-2_33

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