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Small bowel preservation

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Procurement, Preservation and Allocation of Vascularized Organs

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Abstract

Despite early developments in transplantation techniques and preservation of the small bowel, few significant changes have occurred in the last two decades [1–22]. In recent years, however, transplantation of the small bowel has been reintroduced as a potential treatment for acute or chronic irreversible intestinal failure, more often indicated for short small bowel syndrome [23]. Most of the experience with preservation and transplantation of the small bowel has been experimental [1–6,10,13–14,17–22,24]. In the clinical arena, the longest survivor for small bowel transplantation has lived more than 3 years, with satisfactory results, after receiving bowel with liver and other organs in a cluster operation [25]. As better results of small bowel transplantation (SBTx) are obtained, a comparative analysis with established techniques of ambulatory parenteral nutrition (APN) will have to be attained in order to offer the best perspective for patients with end stage small bowel disease (ESSBD) [23].

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References

  1. Lillehei RC, Gott B, Miller FA. The physiologic response of the small bowel of the dog to ischemia, including in vitro preservation of bowel with successful replacement and survival. Ann Surg 1959; 150: 543–560.

    Article  PubMed  CAS  Google Scholar 

  2. Lillehei RC, Goldberg S, Gott B and Longerbeam JK. The present status of small bowel transplantation. Am J Surg 1963; 105: 58–72.

    Article  PubMed  CAS  Google Scholar 

  3. Lillehei RC, Idezuki Y, Feemster JA, Dietzman RH et al. Transplantation of stomach, intestine and pancreas: experimental and clinical observations. Surgery, 1967; 62: 721–41.

    PubMed  CAS  Google Scholar 

  4. Cohen WB, Hardy MA, Quint J and State D. Absorptive function in canine jejunal autografts and allografts. Surgery 1969; 65: 440–6.

    PubMed  CAS  Google Scholar 

  5. Toledo-Pereyra LH, Najarian JS. Small bowel preservation: Comparison of perfusion and non-perfusion systems. Arch Surg 1973; 107: 875–7.

    Article  PubMed  CAS  Google Scholar 

  6. Toledo-Pereyra LH. Small bowel preservation. In: Toledo-Pereyra LH (ed.), Basic concepts of organ procurement, perfusion and preservation for transplantation. Academic Press, New York 1982; pp. 317–331.

    Google Scholar 

  7. Toledo-Pereyra LH. Small bowel preservation: evolution of methods and ideas and current concepts. Transplant Proc 1992; 24: 1083–4.

    PubMed  CAS  Google Scholar 

  8. Southard JH, Marsh DC, McAnulty JF and Belzer FO. Oxygen-derived free radical damage in organ preservation: Activity of superoxide dismutase and xanthine oxidase. Surgery 1987; 101: 566–70.

    PubMed  CAS  Google Scholar 

  9. Grace PA. Ischaemia-Reperfusion injury. Br J Surg 1994; 81: 637–47.

    Article  PubMed  CAS  Google Scholar 

  10. Toledo-Pereyra LH, Granger DN. Small bowel ischemic and reperfusion injury: Pathophysiological mechanisms. In: Das DK (ed.). Pathophysiology of reperfusion injury. CRC Press, Boca Raton, 1993; pp. 137–47.

    Google Scholar 

  11. Parks DA, Bulkley GB and Granger DN. Role of oxygen free radicals in shock, ischemia and organ preservation. Surgery 1983; 94: 428–34.

    PubMed  CAS  Google Scholar 

  12. Calne RY, White DJG. The use of cyclosporin A in clinical organ grafting. Ann Surg 1982; 196: 330–7.

    Article  PubMed  CAS  Google Scholar 

  13. Raju S, Didlake RH, Cayirli M et al. Experimental small bowel transplantation utilizing cyclosporine. Transplantation 1984; 38: 561–6.

    Article  PubMed  CAS  Google Scholar 

  14. Diliz-Perez HS, McClure J, Bedetti C et al. Successful small bowel transplantation in dogs with cyclosporine and Prednisone. Transplantation 1984; 37: 127–32.

    Article  Google Scholar 

  15. Whalberg JA, Southard JH, and Beizer FO. Development of a cold storage solution for pancreas preservation. Cryobiology 1986; 23: 477–81.

    Article  Google Scholar 

  16. Beizer FO, D’Alessandro AM, Hoffmann RM et al The use of UW in clinical transplantation. Ann Surg 1992; 215: 579–85.

    Article  Google Scholar 

  17. Schweizer E, Gassei AM, Deltz E and Schroecer P. A comparison of preservation solutions for small bowel transplantation in the rat. Transplantation 1994; 57: 1406–8.

    Article  PubMed  CAS  Google Scholar 

  18. Rodríguez-Quilantán FJ, Toledo-Pereyra LH, Suzuki S. Total heterotopic small bowel transplantation in the rat: Technical considerations in the procurement, preservation and transplantation of the graft. Gac Med Mex 1993; 129: 131–7.

    Google Scholar 

  19. Rodríguez-Quilantán FJ, Toledo-Pereyra LH, Suzuki S. Role of neutrophils following small bowel transplantation in the rat. Transplant Proc 1993; 25: 3209.

    Google Scholar 

  20. Fabian MA, Bollinger RR, Wyble CW et al. Evaluation of Solution for small intestinal preservation. Biochemical changes as a function of storage time. Transplantation 1991; 52: 794–9.

    Article  PubMed  CAS  Google Scholar 

  21. Rodríguez-Quilantán FJ, Toledo-Pereyra LH, Suzuki S. Twenty-four-hour total small bowel hypothermie storage preservation and transplantation in the rat: A study of various preservation solutions. J Invest Surg 1994; 7: 439–51.

    Article  Google Scholar 

  22. Taguchi T, Zorychta E, Guttman. Evaluation of UW solution for preservation of small intestinal transplants in the rat. Transplantation 1992; 53: 1202–5.

    Article  PubMed  CAS  Google Scholar 

  23. Shanbhogue LKR and Molenaar JC. Short bowel syndrome: metabolic and surgical management. Br J Surg 1994; 81: 486–99.

    Article  PubMed  CAS  Google Scholar 

  24. Toledo-Pereyra LH, Rodríguez-Quilantán FJ. Scientific basis and current status of organ preservation. Transplant Proc 1994; 26: 309–11.

    PubMed  CAS  Google Scholar 

  25. Abu-Elmagd K, Todo S, Tzakis A, Reyes J, Nour B et al. Three years’ clinical experience with intestinal transplantation. J Am Coli Surg 1994; 179: 385–400.

    CAS  Google Scholar 

  26. Sisley MC, Desai T, Harig JM, Gewertz BL. Neutrophil depletion attenuates human intestinal reperfusion injury. J Surg Res 1994; 57: 192–6.

    Article  PubMed  CAS  Google Scholar 

  27. Toledo-Pereyra LH, Suzuki S. Neutrophils, cytokines and adhesion molecules in hepatic ischemic and reperfusion injury. J Am Coli Surg 1994; 174: 758–62.

    Google Scholar 

  28. Mueller AR, Platz KP, Langrehr et al. The effects of administration of nitric oxide inhibitors during small bowel preservation and reperfusion. Transplantation 1994; 58: 1309–16.

    PubMed  CAS  Google Scholar 

  29. Villareal D, Grisham MB, Granger DN. Nitric oxide donors improve gut function after prolonged hypothermie ischemia. Transplantation 1995; 59: 685–9.

    Article  Google Scholar 

  30. Heemann UW, Tullius SG, Azuma H, Kupiec-Weglinsky J, Tilney NL. Adhesion molecules and transplantation. Ann Surg 1994; 219: 4–12.

    Article  PubMed  CAS  Google Scholar 

  31. Murase N, Demetris AJ, Woo J et al. Graft-Versus-Host disease after Brown Norway-to-Lewis and Lewis-to-Brown Norway Rat Intestinal Transplantation Under FK-506. Transplantation 1993; 55: 1–7.

    Article  PubMed  CAS  Google Scholar 

  32. Stepkowski SM, Chen HF, Wang ME et al. Inhibition of host-versus-graft and graft-versus-host responses after small bowel transplantation in rats by rapamyein. Transplantation 1992; 53: 258–64.

    Article  PubMed  CAS  Google Scholar 

  33. Harward TRS. Coe G, Souba WW et al. Glutamine preservesgut glutathione levels during intestinal ischemia/reperfusion. J Sutg Res 1994; 56: 351–5.

    Article  CAS  Google Scholar 

  34. Katz SM, Sun S, Schechner RS et al. Improved small intestinal preservation after lazaroid u74389g treatment and cold storage in University of Wisconsin preservation solution. Transplantation 1995: 59: 694–8.

    Article  PubMed  CAS  Google Scholar 

  35. Sun SC, Greenstein SM, Schechner RS et al. Superoxide dis-mutase: enhanced small intestinal preservation. J Surg Res 1992; 52: 583–90.

    Article  PubMed  CAS  Google Scholar 

  36. Monchik GJ, Russell PS. Transplantation of small bowel in the rat: technical and immunological considérations. Surgery 1971; 70: 693–702.

    PubMed  CAS  Google Scholar 

  37. Kort WJ, Westbroeck DL. MacDicken J, Lameijer LDF. Orthotopic total small bowel transplantation in the rat. Eur Surg Res 1973; 5: 81–9.

    Article  PubMed  CAS  Google Scholar 

  38. Deltz E, Thiede A. Microsurgical Technique for small intestinal transplantation. In: Thiede A, Deltz E, Engemann R (ed.), Microsurgical models in rat for transplantation research. Springer-Verlag. Berlin 1985; pp. 51–5.

    Chapter  Google Scholar 

  39. Wallander J, Holtz A, Larsson E et al. Small-bowel transplantation in the rat with a nonsuture euff technique. Transplant Int 1988; 1: 135–9.

    CAS  Google Scholar 

  40. Schraut WF, Abraham VS, Lee KKW. Portal Versus Caval drainage of small bowel allografts: technical and metabolic consequences.

    Google Scholar 

  41. Grant D, Wall W, Mimeault R, Zhong R et al. Successful small-bowel/liver transplantation. Lancet 1990; 335: 181–4.

    Article  PubMed  CAS  Google Scholar 

  42. Schroeder P, Goulet O and Lear PA. Small-bowel transplantation: European experience. Lancet 1990; 336: 110–11.

    Article  PubMed  CAS  Google Scholar 

  43. Starzl TE, Hakala TR, Shaw BW Jr, Hardesty RL et al. A flexible procedure for multiple cadaveric organ procurement. Surg Gynecol Obstet 1984: 158: 223–30.

    PubMed  CAS  Google Scholar 

  44. Starzl TE, Miller C. Broznick B, Makowka L. An improved technique for multiple organ harvesting. Surg Gynecol Obstet 1987; 165: 343–8.

    PubMed  CAS  Google Scholar 

  45. Todo S, Tzakis A, Abu-Elmagd K, Reyes J, Furukawa H et al. Abdominal multivisceral transplantation. Transplantation 1995; 59: 234–40.

    PubMed  CAS  Google Scholar 

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Authors
  1. Francisco J. Rodríguez-Quilantán
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  2. Luis H. Toledo-Pereyra
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Editor information

Editors and Affiliations

  1. Department of Transplantation, California Pacific Medical Center, San Francisco, California, USA

    G. M. Collins

  2. Transplantation Pavillon V, Hôpital Edouard Herriot, Lyon, France

    J. M. Dubernard

  3. Division of Transplant Surgery, Department of Surgery, Klinikum Grosshadern, University of Munich, Munich, Germany

    W. Land

  4. Eurotransplant Foundation, Leiden, The Netherlands

    G. G. Persijn

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© 1997 Springer Science+Business Media Dordrecht

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Rodríguez-Quilantán, F.J., Toledo-Pereyra, L.H. (1997). Small bowel preservation. In: Collins, G.M., Dubernard, J.M., Land, W., Persijn, G.G. (eds) Procurement, Preservation and Allocation of Vascularized Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5422-2_20

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  • DOI: https://doi.org/10.1007/978-94-011-5422-2_20

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6280-0

  • Online ISBN: 978-94-011-5422-2

  • eBook Packages: Springer Book Archive

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