Abstract
Patients developing end stage renal disease can be treated by haemodialysis, peritoneal dialysis or transplantation. Kidney transplantation is now generally accepted as the primary therapy for chronic renal failure in most patients, with the exception of those who cannot tolerate immunosuppressive treatment or transplant surgery [1]. Many reasons justify the use of kidneys from living donors. Although the overall short and long term results for all donor categories have increased in recent years, transplants from living related donors have a higher success rate than those from cadaver donors [2]. In our experience with living donor transplantation since 1966, survival of kidney grafts from living donors is 20% higher at 10 years than for those from cadaver donors. The introduction of cyclosporin was responsible for increased survival of all categories of transplants. In our series this increase was 15% for cadaveric donors and 20% for living donors. The benefit was more pronounced in patients receiving kidneys from parents (+35%) and, in this category, no effect of age was observed in the long term analysis.
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References
Briggs JD. The recipient of a renal transplant. In: Morris PJ (ed.) Kidney Transplantation. WB Saunders Co., Philadelphia 1988, pp. 71–92.
Najarian JS, Matas AJ. The present and future of kidney transplantation. Transplant Proc 1991; 23: 2075–82.
France Transplant. Rapport annuel, 1993.
Canadian Transplant Study Group. Examination of parameters influencing the benefit detriment ratio of ciclosporine in renal transplantation. Am J Kidney Dis 1985; 5: 328–32.
Breimer ME, Samuelsson BE. The specific distribution of glycolipid-based blood group A antigens in human kidney related to Al/A2, Lewis and secretor status of single individuals. Transplantation 1986; 42: 88–91.
Alexandre GP, Squifflet JP, Debruyere M et al. Present experience in a series of 26 ABO incompatible living donor renal allografts. Transplant Proc 1987; 19: 4538–42.
Kamstra-Hennen L, Beebe J, Stumm S et al. Ethical evaluation of related donation: the donor after five years. Transplant Proc 1981; 13: 60–1.
Hadj-Aissa A, Bankir L, Eraysse Met al. Influence of the level of hydration on the renal response to a protein seal. Kidney Int 1992; 42: 1207–16.
Cantarovich D, Alcazar-Flores R, Piatti PM et al. Selection of living kidney donors: 90 of 248 compatible volunteers were not accepted. In: Touraine JL et al. (eds). Transplantation and Clinical Immunology. Elsevier Science Publishers, Amsterdam 1985; 24: 241–43.
Goto Y, Kakizaki M, Toyota T. Heredity of diabetes mellitus. In: Melish JS, Hanna J, Baba S (eds). Genetic Environmental Interaction of Diabetes Mellitus. Excerpta Medica, Amsterdam 1982; pp. 18–29.
Milutinovic J, Fialkow PJ, Phillips LA et al. Autosomal dominant polycystic kidney disease: early diagnosis and data for genetic counselling. Lancet 1980; 1: 1203–6.
Bay WH, Hebert LA. The living donor in kidney transplantation. Ann Intern Med 1987; 106: 719–27.
Lahita RG, Chiorazzi N, Gibotesky A, Winchester RJ, Kunkel FIG. Family systemic lupus erythematosus in males. Arthritis Rheum 1983; 26: 39–44.
Pouteil Noble C, Betuel H, Freidel AC, Dubernard JM, Touraine JL. Correlation between the allogenic proliferative response and the outcome of renal transplantation. Transplant Proc 1987; 19: 3637–9.
Dandavino R, Beaudry C, Girard R, Bastiene E, Pison C, Houde M. Growth response of an adult hypoplastic kidney transplanted in a living related recipient. Transplantation 1985; 40: 723–4.
Waltzer WC. Engen DE. Stanson AW et al. Use of radiographically abnormal kidneys in living related donor renal transplantation. Nephron 1985; 39: 302–5.
Brandina L, Fraga AMA, Bergonse MRR et al. Kidney transplantation: the use of abnormal kidneys. Nephron 1983; 35: 78–81.
Najarian S, Chavers BM, McHugh LE, Matas AJ. 20 years or more of follow-up of living kidney donors. N Engl J Med 1992:340:807–10.
Bennett AM. Harrison JM. Experience with living familial related donors. Surg Gynecol Obstet 1974; 139: 894–8.
Starzl TE. Living donors. Transplant Proc 1987; 19: 174–6.
Bonomini V. Gozzetti G. Is living donation still justifiable? Nephrol Dial Transplant 1990; 5: 407–9.
Levey AS, Hou S. Bush HL. Kidney transplantation from unrelated living donors. N Engl J Med 1986; 314: 914–16.
Weiland D, Sutherland DER, Chavers B et al. Information on 628 living-related kidney donors at a single institution, with long term follow-up in 472 cases. Transplant Proc 1984; 16: 5–7.
Beekman GM, Van Dorp WT, Van Es LA et al. Analysis of donor selection procedure in 139 living-related kidney donors and follow-up results of donors and recipients. Nephrol Dial Transplant 1994; 9: 163–8.
Andersen B, Hansen JB, Jorgensen SJ. Survival after nephrectomy. Scand J Urol Nephrol 1968; 2: 91–4.
Brenner BM. Hemodynamically mediated glomerular injury and the progressive nature of kidney disease. Kidney hit 1983; 23: 647–55.
Robitaille P, Mongeau JG, Lortie L et al. Long term follow-up of patients who underwent unilateral nephrectomy in childhood. Lancet 1985; x: 1297–9.
Williams S, Oler J, Jorkasky DK. Long term renal function in kidney donors: a comparison of donors and their siblings. Ann Intern Med 1986; 105: 1–8.
Warrick TJ, Jenkins RR, Rackoff P et al. Microalbuminuria and hypertension in long term renal donors. Transplantation 1988; 45: 59–65.
Vicentini F. Amen WJC, Keysen G et al. Long term renal function in kidney donors: sustained compensatory hyperfiltration with no adverse effects. Transplantation 1983; 36: 626–9.
Ogden DA. Consequences of renal donation in man. Am J Kidney Dis 1983; 105: 1–8.
Hadj-Aissa A, Cochat P, Pozet N et al. Renal function studies before and after nephrectomy in renal donors. Transplant Clin Immunol 1985: 16: 249–52.
Fourcade J. Evolution à long term de la fonction rénale chez 99 donneurs vivants. Thèse Lyon 1994.
Hadj-Aissa A, Pozet N. Facteurs d’adaptation fonctionnelle du rein restant après néphrectomie chez les donneurs vivants. Pédiatrie 1993; 48: 102–4.
Anderson RE. Bueschen AJ, Lloyd K et al. Short term and long term changes in renal function after donor nephrectomy. J Urol 1991: 145: 11–13.
Higashihara E, Hone S, Takeuchi T et al. Long term consequences of nephrectomy. J Urol 1990; 143: 239–43.
Schmitz A, Christensen CK, Christensen T et al. No microalbuminuria or other adverse effects of long standing hyper-filtration in humans with one kidney. Am J Kidney Dis 1989; 13: 131–6.
Anderson C, Velosa JA, Frohnert PP et al. The risks of unilateral nephrectomy: status of kidney donors 10 to 20 years post-operatively. Mayo Clin Proc 1985; 60: 367–74.
Talseth T, Fauchald P, Skrede S et al. Long term blood pressure and renal function in kidney donors. Kidney Int 1986; 29: 1072–6.
Morris P, St George B, Waring T et al. Psychosocial complications in living related kidney donors: an Australian experience. Transplant Proc. 1982; 19: 2840–4.
Boisriveaud C. Les problèmes psychologiques des donneurs vivants dans la transplantation renale. Psychol Méd 1994; 26: 159–61.
Bonomini V. Ethical aspects of living donation. Transplant Proc 1991; 23: 2497–9.
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© 1997 Springer Science+Business Media Dordrecht
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Lefrancois, N., Touraine, J.L. (1997). Living kidney donation: preoperative evaluation and preparation for surgery. In: Collins, G.M., Dubernard, J.M., Land, W., Persijn, G.G. (eds) Procurement, Preservation and Allocation of Vascularized Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5422-2_1
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DOI: https://doi.org/10.1007/978-94-011-5422-2_1
Publisher Name: Springer, Dordrecht
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