Abstract
According to modern views, an ideal vaccine must provide a life-long immunization effect in 100% of the vaccinated persons, should be safe, thermostable, cheap, and should not be administered parenterally. As known, the most important feature of live vaccines against respiratory infections is rapid development of local secretory immunity in the portal of respiratory and intestinal tracts. We have developed a new technology for production of peroral live measles vaccine where a special attention is paid to optimization of biological stabilizers. The vaccine trials in rabbits, the tablet and capsule forms of the preparation being administered intraduodenally, revealed a stimulation of humoral and cellular immunity and demonstrated the absence of side effects.
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© 1997 Springer Science+Business Media Dordrecht
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Nechaeva, E.A. et al. (1997). Development of Production Technology of Live Measles Vaccine for Peroral Administration. In: Carrondo, M.J.T., Griffiths, B., Moreira, J.L.P. (eds) Animal Cell Technology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5404-8_32
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DOI: https://doi.org/10.1007/978-94-011-5404-8_32
Publisher Name: Springer, Dordrecht
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