Abstract
Since the introduction of gene cloning and gene transfer more than two decades ago animal cell culture has undergone a dramatic transformation from a research tool and highly specialized niche technology to a central resource of innovation in pharmaceutical research and development. Many of the most successful drugs introduced to the market in recent years were discovered in cell culture supernatants, evaluated in cell culture models and produced by large scale animal cell fermentation. Best known examples include interferons, erythropoetin, various interleukins and cytokines and tissue-type Plasminogen activator (t-PA).
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References
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© 1997 Springer Science+Business Media Dordrecht
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Schleuning, WD. (1997). Applications of Animal Cell Technology to Drug Discovery and Pharmacology. In: Carrondo, M.J.T., Griffiths, B., Moreira, J.L.P. (eds) Animal Cell Technology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5404-8_2
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DOI: https://doi.org/10.1007/978-94-011-5404-8_2
Publisher Name: Springer, Dordrecht
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