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Oxalate and urolithiasis

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The Management of Lithiasis

Part of the book series: Developments in Nephrology ((DINE,volume 38))

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Abstract

The importance of oxalic acid in medicine derives from the extreme insolubility of its calcium salt in water, at around 12 mg or 0.13 mM per litre, which is affected little by pH above 5, but increases as the pH falls below 5 [1]. Because calcium and oxalate require to be excreted in substantial quantities by the kidneys, averaging 4–5 mM and 0.3 mM per day respectively in the adult, urinary supersaturation with calcium oxalate is the norm. Complex and elaborate mechanisms exist to prevent the formation, growth and agglomeration of crystals in the urinary tract, processes which are believed to be precursors of stone formation.

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Authors
  1. Roger A. L. Sutton
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Editors and Affiliations

  1. The Aga Khan University Medical Center, Karachi, Pakistan

    Jamsheer Talati , Roger A. L. Sutton , Farhat Moazam  & Mushtaq Ahmed , ,  & 

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Sutton, R.A.L. (1997). Oxalate and urolithiasis. In: Talati, J., Sutton, R.A.L., Moazam, F., Ahmed, M. (eds) The Management of Lithiasis. Developments in Nephrology, vol 38. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5396-6_7

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  • DOI: https://doi.org/10.1007/978-94-011-5396-6_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6270-1

  • Online ISBN: 978-94-011-5396-6

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