Abstract
The Tayside Medicines Monitoring Unit (MEMO) database is a record-linkage system prospectively built for the purposes of carrying out pharmacoepidemiological research. MEMO links community dispensed prescribing data with hospitalization morbidity data. MEMO collects data on all dispensed drugs in Tayside. Data on all NSAIDs and ulcer healing drugs (UHDs) are available from 1989 onwards. Using this resource, studies that have been carried out have demonstrated the safety of topically applied NSAIDs, have shown that the risk of upper gastrointestinal complications associated with oral NSAIDs is constant with continuous exposure, and have quantified the attributable risk of NSAIDs for any given combination of risk factors. The rank order of NSAID toxicity in these studies has been similar to those from other recent studies using data from different sources.
MEMO has also ecamined the associations berween NSAID exposure and colorectal cancer, colitis, appendicetomy, cholecystectomy and acute renal failure
The MEMO record-linkage database is a powerful tool for quantifying the side-effects of NSAIDs. MEMO is currently exploring mechanisms for expanding its capability to the population of Scotland.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Beardon PHG, McGilchrist MM, McKendrick AD, McDevitt DG, MacDonald TM. Primary noncompliance with prescribed medication in primary care. Br Med J. 1993;307:846–8.
MacDonald TM, McDevitt DG. The Tayside Medicines Monitoring Unit (MEMO). In: Strom BL, ed. Pharmacoepidemiology, 2nd edn. Chichester: John Wiley; 1994:245–55.
Garcia-Rodriguez CA, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs. Lancet. 1994;343:769–72.
Langman MJS, Weil J, Wainwright P, et al. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet. 1994;343:1075–8.
Evans JMM, McMahon AD, McGilchrist MM, et al. Topical non-steroidal anti-inflammatory drugs and admission to hospital for upper gastrointestinal bleeding and perforation: a record-linkage case-control study. Br Med J. 1995;311:22–6.
MacDonald TM, Morant SV, Robinson GC, et al. Risk of upper GI complications is constant continuous NSAID therapy: A record-linkage study. Gut. 1995;36(suppl. 1):A59(Abstract F236).
McMahon AD, White G, Murray FE, McGilchrist MM, McDevitt DG, MacDonald TM. New exposure to NSAIDs and hospitalisation for upper gastrointestinal events and haemorrhage. A record-linkage study in the population of Tayside, Scotland. Presented at: Digestive Diseases Week American Gastroenterology Association, San Diego, May 1995; Abstract No. 3136.
Thun MJ, Namboodiri MM, Heath CW. Aspirin use and reduced risk of fatal colon cancer. N Engl J Med. 1991;325:1593–6.
Peipins LA, Sandler RS. Epidemiology of colorectal adenomas. Epidemiol Rev. 1994;16:273–97.
Logan RFA, Little J, Hawtin PE, Hardcastle JD. Effects of aspirin and non-steroidal anti-inflammatory drugs on colo-rectal adenomas: a case-control study of subjects participating in the Nottingham faecal occult blood screening programme. Br Med J. 1993;307:285–9.
MacDonald TM, Evans JMM, McMahon AD, et al. Non-steroidal anti-inflammatory drugs, aspirin and colo-rectal cancer: A record-linkage case-control study. Gut. 1995;36(suppl. 1):A24(Abstract T93).
Kaufmann HJ, Taubin HC. Non steroidal anti-inflammatory drugs activate quiescent inflammatory bowel disease. Ann Intern Med. 1987;107:513–6.
Gibson GR, Whitacre EB, Ricotti CA. Colitis induced by non-steroidal anti-inflammatory drugs. Arch Intern Med. 1992;152:625–32.
Evans JMM, McMahon AD, McGilchrist MM, et al. Non-steroidal anti-inflammatory drugs and colitis: A record-linkage case-control study. Presented at: International Society of Pharmacoepidemiology, Montreal, August 1995.
Whelton A, Stout RL, Spilman PS, Klassen DK. Renal effects of ibuprofen piroxicam and sulindac in patients with asymptomatic renal failure: A prospective randomized crossover comparison. Ann Intern Med. 1990;112:568–76.
Orme ML’E. Non-steroidal anti-inflammatory drugs and the kidney. Br Med J. 1986;292:1621–2.
Murray MD, Brater DC. Adverse effects of non-steroidal anti-inflammatory drugs on renal function. Ann Intern Med. 1990;112:559–60.
Evans JMM, McGregor E, McMahon AD, et al. Non-steroidal anti-inflammatory drugs and hospitalisation for acute renal failure. Q J Med. 1995;88:551–7.
Fries JF. The toxicity of anti-rheumatic drugs. Problems and solutions. Proc R Coll Phys Edin. 1995;25:398–405.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
MacDonald, T.M. (1997). Side-Effects of Non-Steroidal Anti-Inflammatory Drugs: Studies from the Tayside Medicines Monitoring Unit. In: Rainsford, K.D. (eds) Side Effects of Anti-Inflammatory Drugs IV. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5394-2_3
Download citation
DOI: https://doi.org/10.1007/978-94-011-5394-2_3
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6269-5
Online ISBN: 978-94-011-5394-2
eBook Packages: Springer Book Archive