Abstract
Increased understanding of the damaging and protecting factors in the gastrointestinal tract opens up possibilities of safer use of NSAIDs or the development of safer NSAIDs in preventing gastrointestinal tract damage. Highly effective gastric acid suppression can successfully prevent both duodenal and gastric lesions associated with NSAIDs. The development of synthetic prostaglandin analogues and drugs with a selective prostaglandin effect has been shown to be successful, although the side-effects of current prostaglandin analogues limits their use. Selective prostaglandin drugs such as etodolac have been shown in prospective endoscopic studies significantly to reduce damage, and this is associated with less suppression of gastrointestinal prostaglandins than conventional NSAIDs.
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© 1997 Springer Science+Business Media Dordrecht
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Russell, R.I. (1997). Protection from Nsaid-Induced Gastrointestinal Damage. In: Rainsford, K.D. (eds) Side Effects of Anti-Inflammatory Drugs IV. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5394-2_16
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DOI: https://doi.org/10.1007/978-94-011-5394-2_16
Publisher Name: Springer, Dordrecht
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