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Side Effects of Anti-Inflammatory Drugs IV pp 139–152Cite as

A Clinician’s View of Strategies for Preventing Nsaid-Induced Gastrointestinal Ulcers

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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs in the world. Each year approximately 100 million NSAID prescriptions are dispensed in the United States [1]. In Canada in 1989, there were 10.7 million prescriptions for NSAIDs [2], a growth rate of 6% per year [3]. In the United Kingdom, nearly 22 million prescriptions for NSAIDs were issued in 1985 [4]. Despite the undoubted efficacy of NSAIDs in pain relief in patients with arthritis and musculoskeletal pain, all have the potential to cause a number of clinically significant gastrointestinal (GI) adverse effects. Although these effects are generally restricted to minor injury to the gastrointestinal mucosa, epidemiological studies have indicated a three- to fourfold increase in gastric ulceration, upper GI bleeding and complicated duodenal ulcer [5], especially in a high-risk population; the sequelae of using NSAIDs may result in life-threatening complications and these may occur without any warning symptoms [6]. The purpose of this article is to review, from a clinician’s point of view, the wide spectrum of GI damage induced by NSAIDs, the possible mechanism of action of NSAIDs and strategies for treating and preventing NSAID-induced GI lesions.

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  1. Department of Medicine, Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Room 4W8, Hamilton, Ontario, L8N 3Z5, Canada

    J. Huang & R. H. Hunt

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  1. Division of Biomedical Sciences, School of Science and Medicine, Sheffield Hallam University, Sheffield, UK

    K. D. Rainsford

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Huang, J., Hunt, R.H. (1997). A Clinician’s View of Strategies for Preventing Nsaid-Induced Gastrointestinal Ulcers. In: Rainsford, K.D. (eds) Side Effects of Anti-Inflammatory Drugs IV. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5394-2_15

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  • DOI: https://doi.org/10.1007/978-94-011-5394-2_15

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