Summary
Factors determining a drug’s potency/toxicity include not only those of an intrinsic nature, by virtue of its chemical structure, but also extrinsic ones, particularly the environment in which its bioreactivity will be expressed. These extrinsic factors may be used accidentally, or by design, to determine/condition a drug’s performance. Such conditioning factors (CF), particularly if they are disease-related, may allow the drug action to be focused or amplified. This is illustrated by the following three examples.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Whitehouse, M.W. (1997). Inflammation, Stress and Environmental Factors as Determinants of Nsaid Efficacy and Toxicity. In: Rainsford, K.D. (eds) Side Effects of Anti-Inflammatory Drugs IV. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5394-2_12
Download citation
DOI: https://doi.org/10.1007/978-94-011-5394-2_12
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6269-5
Online ISBN: 978-94-011-5394-2
eBook Packages: Springer Book Archive