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The Response of Odontoblasts to Injury to Epithelial Integrity: Review

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Cell Injury and Protection in the Gastrointestinal Tract

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Abstract

The odontoblast cells can be exposed to the irritating effect of various noxious agents under carious lesions or abrasion of enamel and under the damaged cells of the epithelial sulcus. The odontoblasts have the potential for recovery and repair which can be detected at the light and electron-microscopical levels. The corresponding dentine reactions represent a continuum of dentineal reactions. Bacterial invasion into the dentine in relation to the activity of underlying odontoblasts has been examined by several authors. Two different types of reaction may occur: secondary dentine formation at the pulp—dentine border and the dentinal tubules may become obturated by growth of the peritubular dentine or by precipitation of materials within the tubules. Precipitation of materials is considered to be a passive physical—chemical process but the growth of peritubular dentine and secondary dentine formation is a typical vital response, requiring odontoblast activity. Lesions restricted to the outer third of the dentine have a positive effect on the metabolism of injured odontoblasts, which appears as an increased rate of synthesis observed by measurement of enzyme activities. The effect of growth factors, peptide hormones and brain—gut peptides on odontoblast response requires further studies.

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Authors and Affiliations

  1. School of Dentistry, Medical University of Pécs, Pécs, Hungary

    J. Szabó & G. Varbiró

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  1. J. Szabó
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  2. G. Varbiró
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Editors and Affiliations

  1. Pécs, Hungary

    Gy. Mózsik , L. Nagy  & A. Pár ,  & 

  2. Sheffield, UK

    K. D. Rainsford

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© 1997 Springer Science+Business Media Dordrecht

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Szabó, J., Varbiró, G. (1997). The Response of Odontoblasts to Injury to Epithelial Integrity: Review. In: Mózsik, G., Nagy, L., Pár, A., Rainsford, K.D. (eds) Cell Injury and Protection in the Gastrointestinal Tract. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5392-8_7

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  • DOI: https://doi.org/10.1007/978-94-011-5392-8_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6268-8

  • Online ISBN: 978-94-011-5392-8

  • eBook Packages: Springer Book Archive

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