Abstract
Cancer susceptibility is influenced by genetic polymorphisms of enzymes metabolising and detoxifying carcinogenic chemical compounds. Phenotypic and genetic differences in cytochrome P450 1A1, 2E1 and GSTM1 enzymes often correlate with occurrence of certain cancers. Beside lung and bladder cancer, there is considerable evidence that colorectal tumours are also affected by these polymorph-isms. We have examined the distribution of genotypes among non-familiar colon tumour patients and controls. There was a moderate effect of each polymorphism on colon cancer sensitivity alone, but the combination of the three high-risk alleles was significantly associated with increased risk of colon cancer (RR: 1.73, CI: 1.07–2.81).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
McMichael AJ. Molecular epidemiology: new pathway or new travelling companion? Am J Epidemiol. 1994;140:1–11.
Perera FP. Molecular cancer epidemiology: a new tool in cancer prevention. J Natl Cancer Inst. 1987;78:887–98.
Perera FP, Weinstein IB. Molecular epidemiology and carcinogen-DNA adduct detection: new approaches to studies of human cancer causation. J Chron Dis. 1982;35:581–600.
Ember I, Raposa T, Varga Cs, Kiss I. Effect of different cytostatic protocols on oncogene expression in CBA/Ca mice. Anticancer Res. 1995;15:1285–8.
Kozma L, Kiss I, Szakâll Sz, Ember I. Investigation of c-myc oncogene amplification in colorectal cancer. Cancer Lett. 1994;81:165–9.
Kiss I, Ember I, Dersényi E, Csécsei Gy. Activation of different oncogenes in malignant brain tumors. Cancer Detect Prey. 1993;17:97.
Taylor YA, Bell DA, Nagorney D. L-myc proto-oncogene alleles and susceptibility to hepatocellular carcinoma. Int J Cancer. 1993;54:927–30.
Zhong S, Wyllie AH, Barnes D, Wolf CR, Spurr NK. Relationship between GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis. 1993;14:1821–4.
E Thelu MA, Zarski JP, Froissart B, Rachail M, Seigneurin JM. c-Ha-ras polymorphism in patients with hepatocellular carcinoma. Comparison of healthy subjects and alcoholic patients with cirrhosis. Gastroenterol Clin Biol. 1993;17:903–7.
Hayashi S, Watanabe J, Nakachi K, Kawajiri K. Genetic linkage of lung-cancer associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IaI gene. J Biochem. 1991;110:407–11.
Sivaraman L, Leathem MP, Yee Y, Wilkens LR, Lau AF, Le Marchand L. CYP1A1 genetic polymorphism and in situ colorectal cancer. 1994;54:3692–5.
Hirvonen A, Husgafvel-Pursiainen K, Karjalainen A, Anttila S, Vainio H. Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: Lack of association with susceptibility to lung cancer in a Finnish population. Cancer Epid Biom Prey. 1992;1:485–9.
Rannung A, Alexandrie A-K, Persson I, Ingelman-Sundberg M. Genetic polymorphism of cytochromes P450 1A1, 2D6 and 2E1: Regulation and toxicological significance. J Occup Environ Med. 1995;37:25–36.
Uematsu F, Kikuchi H, Ohmachi T et al. Two common RFLPs of the human CYP2E gene. Nucl Acids Res. 1991;19:2803.
Lin HJ, Han C-Y, Bernstein DA, Hsiao W, Lin BK, Hardy S. Ethnic distribution of the glutathione transferase Mu 1–1 (GSTM1) null genotype in 1473 individuals and application to bladder cancer susceptibility. Carcinogenesis. 1994;15:1077–81.
Chenevix-Trench G, Young J, Coggan M, Board P. Glutathione-S-transferase M1 and Ti polymorph-isms: susceptibility to colon cancer and age of onset. Carcinogenesis. 1995;16:1655–7.
Uematsu F, Kikuchi H, Motomiya M et al. Association between restriction fragment length polymorphism of the human cytochrome P450IIE1 gene and susceptibility to lung cancer. Jpn J Cancer Res. 1991;82:254–6.
Hirvonen A, Husgafvel-Pursiainen K, Anttila S, Karjalainen A, Vainio H. The human CYP2E1 gene and lung cancer: Dral and RsaI restriction fragment length polymorphisms in a Finnish study population. Carcinogenesis. 1993;14:85–8.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Kiss, I., Ember, I. (1997). Genetic Polymorphisms of CYP1A1, CYP2E1, and GSTM1 Genes: Susceptibility to Colon Cancer. In: Mózsik, G., Nagy, L., Pár, A., Rainsford, K.D. (eds) Cell Injury and Protection in the Gastrointestinal Tract. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5392-8_34
Download citation
DOI: https://doi.org/10.1007/978-94-011-5392-8_34
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6268-8
Online ISBN: 978-94-011-5392-8
eBook Packages: Springer Book Archive