Abstract
Chloride secretion is under the intracellular control of at least three intracellular second messenger pathways, the cAMP-, the Cа2+- and the cGMP-system. An increase in the intracellular cAMP concentration causes the opening of apical Cl- channels and a stimulation of the basolateral Na+-K+-C1--cotransporter responsible for intracellular C1- accumulation. In contrast, the effect of intracellular Ca2+ is, at least in isolated crypts from the rat distal colon, restricted to the opening of a basolateral Са2+-dependent K+ conductance, which leads to a hyperpolarization of the membrane and thereby increases the driving force for Cl- exit across spontaneously open apical Cl- channels. In the rat distal colon, there is evidence for a modulation of cAMP-mediated secretion by intracellular cGMP, which affects Cl- secretion indirectly via a cGMP-sensitive phosphodiesterase, an enzyme which is responsible for cAMP degradation. These studies suggest a complex interaction of all three signalling pathways in the intracellular regulation of Cl- secretion.
Correspondence
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Diener, M. (1997). Mechanisms and Regulation of C1- Secretion in the Large Intestine: Studies with the Rat Distal Colon. In: Gaginella, T.S., Mózsik, G., Rainsford, K.D. (eds) Biochemical Pharmacology as an Approach to Gastrointestinal Disorders. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5390-4_9
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DOI: https://doi.org/10.1007/978-94-011-5390-4_9
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